AutismKB 2.0

Annotation Details for PLAUR


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Basic Information Top
Gene Symbol:PLAUR ( CD87,UPAR,URKR )
Gene Full Name: plasminogen activator, urokinase receptor
Band: 19q13
Quick LinksEntrez ID:5329; OMIM: 173391; Uniprot ID:UPAR_HUMAN; ENSEMBL ID: ENSG00000011422; HGNC ID: 9053
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005886IDA-plasma membrane12665524
GO:0005886TAS-plasma membrane-
GO:0005887IEA-integral component of plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0009986IDA-cell surface15922359
GO:0016021NAS-integral component of membrane1689240
GO:0019898TAS-extrinsic component of membrane8049431
GO:0031225IEA-anchored component of membrane-
GO:0035579TAS-specific granule membrane-
GO:0070062IDA-extracellular exosome23376485
GO:0071438IEA-invadopodium membrane-
GO ID Evidence Qualifier GO_term References
GO:0004872NAS-receptor activity1689240
GO:0005102IPI-receptor binding12665524
GO:0005515IPI-protein binding11290596
GO:0019899IPI-enzyme binding14688365
GO:0019904IPI-protein domain specific binding12665524
GO:0030377IBA-urokinase plasminogen activator receptor activity-
GO:0030377NAS-urokinase plasminogen activator receptor activity1689240
GO ID Evidence Qualifier GO_term References
GO:0001934IMP-positive regulation of protein phosphorylation22984561
GO:0006928NAS-movement of cell or subcellular component1689240
GO:0006935TAS-chemotaxis10749881
GO:0007165TAS-signal transduction10749881
GO:0007596NAS-blood coagulation8392005
GO:0016255TAS-attachment of GPI anchor to protein-
GO:0030162NAS-regulation of proteolysis1689240
GO:0038195IBA-urokinase plasminogen activator signaling pathway-
GO:0042730TAS-fibrinolysis-
GO:0043066IMP-negative regulation of apoptotic process22984561
GO:0043312TAS-neutrophil degranulation-
GO:0043388IDA-positive regulation of DNA binding22984561
GO:0045742IMP-positive regulation of epidermal growth factor receptor signaling pathway22984561
GO:0090200IMP-positive regulation of release of cytochrome c from mitochondria22984561
GO:2001243IMP-negative regulation of intrinsic apoptotic signaling pathway22984561
GO:2001268IMP-negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway22984561
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PLAUREEF1A111134516169070 Two-hybrid
PLAUREEF1A110823716169070 Two-hybrid
PLAURFAP11134512376466 FRET
PLAURFAP10848512376466 FRET
PLAURIGF2R1097039566979 Reconstituted Complex
PLAURIGF2R1113459566979 Reconstituted Complex
PLAURITGAM10989010744708 Reconstituted Complex
PLAURITGAM11134510744708 Reconstituted Complex
PLAURITGB210989510388537 Affinity Capture-Western
PLAURITGB211134510388537 Affinity Capture-Western
PLAURJAK11099199417082 Affinity Capture-Western
PLAURJAK11113459417082 Affinity Capture-Western
PLAURKNG111002614764580 Reconstituted Complex
PLAURKNG111134514764580 Reconstituted Complex
PLAURLRP111021511359936 Affinity Capture-Western; Reconstituted Complex
PLAURLRP111134511359936 Affinity Capture-Western; Reconstituted Complex
PLAURPFN211123816169070 Two-hybrid
PLAURPFN211134516169070 Two-hybrid
PLAURPLAU11134511501527 Reconstituted Complex
PLAURPLAU11134411501527 Reconstituted Complex
TYK2PLAUR1113459417082 Affinity Capture-Western
TYK2PLAUR1131489417082 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97612
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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