AutismKB 2.0

Annotation Details for PLCG1


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Basic Information Top
Gene Symbol:PLCG1 ( NCKAP3,PLC-II,PLC1,PLC148,PLCgamma1 )
Gene Full Name: phospholipase C, gamma 1
Band: 20q12
Quick LinksEntrez ID:5335; OMIM: 172420; Uniprot ID:PLCG1_HUMAN; ENSEMBL ID: ENSG00000124181; HGNC ID: 9065
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001726IDA-ruffle17229814
GO:0005737IDA-cytoplasm15702972
GO:0005829IDA-cytosol2550068
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane2550068
GO:0005886TAS-plasma membrane-
GO:0005911IEA-cell-cell junction-
GO:0008180IDA-COP9 signalosome22561606
GO:0030027IDA-lamellipodium17229814
GO:0042995IDA-cell projection22454520
GO ID Evidence Qualifier GO_term References
GO:0004435IDA-phosphatidylinositol phospholipase C activity2550068
GO:0004435TAS-phosphatidylinositol phospholipase C activity-
GO:0004629TAS-phospholipase C activity-
GO:0005057NAS-signal transducer activity, downstream of receptor7681365
GO:0005168IPI-neurotrophin TRKA receptor binding15488758
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding1396585
GO:0019901IPI-protein kinase binding22454520
GO:0030971IEA-receptor tyrosine kinase binding-
GO:0035254IEA-glutamate receptor binding-
GO ID Evidence Qualifier GO_term References
GO:0000186TAS-activation of MAPKK activity-
GO:0001701IEA-in utero embryonic development-
GO:0007165NAS-signal transduction7681365
GO:0007165TAS-signal transduction-
GO:0007173IMP-epidermal growth factor receptor signaling pathway22454520
GO:0007411TAS-axon guidance-
GO:0009395IEA-phospholipid catabolic process-
GO:0010634IMP-positive regulation of epithelial cell migration17229814
GO:0016032IEA-viral process-
GO:0016477IMP-cell migration22454520
GO:0019722IMP-calcium-mediated signaling22454520
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0043536IDA-positive regulation of blood vessel endothelial cell migration20011604
GO:0043647TAS-inositol phosphate metabolic process-
GO:0045766IDA-positive regulation of angiogenesis20011604
GO:0050852TAS-T cell receptor signaling pathway-
GO:0050900TAS-leukocyte migration-
GO:0051281IMP-positive regulation of release of sequestered calcium ion into cytosol22454520
GO:0071364IDA-cellular response to epidermal growth factor stimulus17229814
GO:0071364IMP-cellular response to epidermal growth factor stimulus22454520
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PLCG1ABL110654310708759 Reconstituted Complex
PLCG1ABL111135110708759 Reconstituted Complex
PLCG1ALK10673911888936 14968112 Affinity Capture-MS; Affinity Capture-Western
PLCG1ALK11135111888936 14968112 Affinity Capture-MS; Affinity Capture-Western
PLCG1RHOA10688012071848 Affinity Capture-Western; Reconstituted Complex
PLCG1RHOA11135112071848 Affinity Capture-Western; Reconstituted Complex
PLCG1CAMK2A11135118292392 Affinity Capture-Western
PLCG1CAMK2A10726518292392 Affinity Capture-Western
PLCG1CBL1073159712732 12061819 17372230 Affinity Capture-Western; Far Western; Reconstituted Complex
PLCG1CBL1113519712732 12061819 17372230 Affinity Capture-Western; Far Western; Reconstituted Complex
PLCG1CD221113518627166 Affinity Capture-Western
PLCG1CD221073718627166 Affinity Capture-Western
PLCG1DOK111135111071635 Reconstituted Complex
PLCG1DOK110813111071635 Reconstituted Complex
PLCG1EEF1A111135111886851 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
PLCG1EEF1A110823711886851 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
PLCG1EGFR1113519207933 12061819 Affinity Capture-Western
PLCG1EGFR1082769207933 12061819 Affinity Capture-Western
PLCG1EPHB21083629632142 Two-hybrid
PLCG1EPHB21113519632142 Two-hybrid
PLCG1EPOR10837115644415 PCA
PLCG1EPOR11135115644415 PCA
PLCG1ERBB21113511676673 1683701 Affinity Capture-Western; Co-fractionation
PLCG1ERBB21083761676673 1683701 Affinity Capture-Western; Co-fractionation
PLCG1FGFR11085519660748 Two-hybrid
PLCG1FGFR11113519660748 Two-hybrid
PLCG1FLT11113519398617 Reconstituted Complex; Two-hybrid
PLCG1FLT11086099398617 Reconstituted Complex; Two-hybrid
PLCG1GAB11088248596638 11507676 Affinity Capture-Western; Far Western
PLCG1GAB11113518596638 11507676 Affinity Capture-Western; Far Western
PLCG1GHR1089579632636 Reconstituted Complex
PLCG1GHR1113519632636 Reconstituted Complex
PLCG1GRB21091427629168 9281317 10940929 Affinity Capture-Western; Reconstituted Complex
PLCG1GRB21113517629168 9281317 10940929 Affinity Capture-Western; Reconstituted Complex
PLCG1GSN1091899164868 Reconstituted Complex
PLCG1GSN1113519164868 Reconstituted Complex
PLCG1ITK10990710586033 12163161 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PLCG1ITK11135110586033 12163161 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PLCG1KDR1113519398617 Reconstituted Complex
PLCG1KDR1099929398617 Reconstituted Complex
PLCG1KIT1100157536744 11071635 Reconstituted Complex
PLCG1KIT1113517536744 11071635 Reconstituted Complex
PLCG1LCP211135111390650 Affinity Capture-Western; Reconstituted Complex
PLCG1LCP211012911390650 Affinity Capture-Western; Reconstituted Complex
PLCG1LTK1113518084603 Affinity Capture-Western
PLCG1LTK1102368084603 Affinity Capture-Western
PLCG1MST1R1113518918464 Affinity Capture-Western
PLCG1MST1R1105928918464 Affinity Capture-Western
PLCG1NTRK11109691715690 9856458 10092678 10708759 Reconstituted Complex; Two-hybrid
PLCG1NTRK11113511715690 9856458 10092678 10708759 Reconstituted Complex; Two-hybrid
PLCG1NTRK211097010092678 12074588 Reconstituted Complex; Two-hybrid
PLCG1NTRK211135110092678 12074588 Reconstituted Complex; Two-hybrid
PLCG1NTRK311097110092678 Reconstituted Complex
PLCG1NTRK311135110092678 Reconstituted Complex
PLCG1PAK111109512085993 Reconstituted Complex
PLCG1PAK111135112085993 Reconstituted Complex
PLCG1PARK211110518671761 Affinity Capture-Western
PLCG1PARK211135118671761 Affinity Capture-Western
PLCG1PDGFA1113518443409 Affinity Capture-Western
PLCG1PDGFA1111808443409 Affinity Capture-Western
PLCG1PDGFRA1111827535778 Affinity Capture-Western; Reconstituted Complex
PLCG1PDGFRA1113517535778 Affinity Capture-Western; Reconstituted Complex
PLCG1PDGFRB1111858443409 Affinity Capture-Western
PLCG1PDGFRB1113518443409 Affinity Capture-Western
PLCG1PECAM111120110350061 Far Western; Reconstituted Complex
PLCG1PECAM111135110350061 Far Western; Reconstituted Complex
SRCPLCG11113517510703 Affinity Capture-Western
SRCPLCG11125927510703 Affinity Capture-Western
ZAP70PLCG11133677629168 Affinity Capture-Western
ZAP70PLCG11113517629168 Affinity Capture-Western
SYKPLCG11113517831290 Affinity Capture-Western
SYKPLCG11127177831290 Affinity Capture-Western
GNB2L1PLCG11113518290562 Far Western
GNB2L1PLCG11156718290562 Far Western
RETPLCG11119118628282 Reconstituted Complex
RETPLCG11113518628282 Reconstituted Complex
SH2B3PLCG11113518649391 Affinity Capture-Western
SH2B3PLCG11153368649391 Affinity Capture-Western
SHC1PLCG11113518662733 Affinity Capture-Western
SHC1PLCG11123618662733 Affinity Capture-Western
WASPLCG11113518805332 8824280 Reconstituted Complex
WASPLCG11132938805332 8824280 Reconstituted Complex
PRKD1PLCG11115738885868 Affinity Capture-Western
PRKD1PLCG11113518885868 Affinity Capture-Western
PKN2PLCG11115728910519 Reconstituted Complex
PKN2PLCG11113518910519 Reconstituted Complex
SYNCRIPPLCG11157559341187 Reconstituted Complex
SYNCRIPPLCG11113519341187 Reconstituted Complex
LATPLCG11179719489702 9729044 11368773 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
LATPLCG11113519489702 9729044 11368773 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
IRS2PLCG11142099535722 Affinity Capture-Western
IRS2PLCG11113519535722 Affinity Capture-Western
RASA1PLCG11113519743338 Affinity Capture-Western
RASA1PLCG11118569743338 Affinity Capture-Western
KHDRBS1PLCG11159009743338 10467411 11960376 Affinity Capture-Western; Reconstituted Complex
KHDRBS1PLCG11113519743338 10467411 11960376 Affinity Capture-Western; Reconstituted Complex
SH3BP2PLCG11113519846481 11390470 Far Western; Reconstituted Complex
SH3BP2PLCG11123509846481 11390470 Far Western; Reconstituted Complex
VAV1PLCG11132529891995 Affinity Capture-Western
VAV1PLCG11113519891995 Affinity Capture-Western
GAB2PLCG111518110391903 Reconstituted Complex
GAB2PLCG111135110391903 Reconstituted Complex
PTK2PLCG111171910430888 Affinity Capture-Western
PTK2PLCG111135110430888 Affinity Capture-Western
TUBPLCG111312610455176 Affinity Capture-Western; Reconstituted Complex
TUBPLCG111135110455176 Affinity Capture-Western; Reconstituted Complex
SHBPLCG111235810488157 Affinity Capture-Western
SHBPLCG111135110488157 Affinity Capture-Western
TNK1PLCG111425310873601 Reconstituted Complex
TNK1PLCG111135110873601 Reconstituted Complex
SOS1PLCG111253710913276 10940929 Affinity Capture-Western; Reconstituted Complex
SOS1PLCG111135110913276 10940929 Affinity Capture-Western; Reconstituted Complex
PICALMPLCG111390210926122 Reconstituted Complex
PICALMPLCG111135110926122 Reconstituted Complex
SOS2PLCG111253810940929 Affinity Capture-Western; Two-hybrid
SOS2PLCG111135110940929 Affinity Capture-Western; Two-hybrid
BAG3PLCG111490710980614 Affinity Capture-Western; Reconstituted Complex
BAG3PLCG111135110980614 Affinity Capture-Western; Reconstituted Complex
PTPRJPLCG111135111259588 Biochemical Activity
PTPRJPLCG111175911259588 Biochemical Activity
TRPM7PLCG112017711941371 Reconstituted Complex
TRPM7PLCG111135111941371 Reconstituted Complex
ARHGAP32PLCG111135112454018 Affinity Capture-Western
ARHGAP32PLCG111509112454018 Affinity Capture-Western
LAT2PLCG111330112514734 Affinity Capture-Western
LAT2PLCG111135112514734 Affinity Capture-Western
PLD2PLCG111135112646582 Affinity Capture-Western; Reconstituted Complex
PLD2PLCG111135412646582 Affinity Capture-Western; Reconstituted Complex
DGKZPLCG111409512890670 Affinity Capture-Western
DGKZPLCG111135112890670 Affinity Capture-Western
SELEPLCG111230112960351 Affinity Capture-Western
SELEPLCG111135112960351 Affinity Capture-Western
GIT1PLCG111135114523024 Affinity Capture-Western; Reconstituted Complex
GIT1PLCG111878914523024 Affinity Capture-Western; Reconstituted Complex
UBCPLCG111316417372230 18671761 Affinity Capture-Western
UBCPLCG111135117372230 18671761 Affinity Capture-Western
PLXNB2PLCG111717819805522 Affinity Capture-Western
PLXNB2PLCG111135119805522 Affinity Capture-Western
PLXNB1PLCG111135119805522 Affinity Capture-Western
PLXNB1PLCG111137719805522 Affinity Capture-Western
ARHGEF2PLCG111461819805522 Affinity Capture-Western
ARHGEF2PLCG111135119805522 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
PLCG1FGFR125965015117958 An unspecified isoform of FGFR1 interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human PLC-gamma.
LATPLCG121652515696170 LAT interacts with an unspecified isoform of PLC-gamma-1.
RHOUPLCG118515215556869 Wrch-1 interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between human Wrch-1 and PLC-gamma from an unspecified species.
TRPC3PLCG121687715744307 PLCG1 interacts with TRPC3. This interaction was modelled on a demonstrated interaction between rat PLCG1 and human TRPC3.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
PLCG1rs8192707 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
PLCG1rs2076146, rs2235360, rs2866370, rs6093446 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97615
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030421-3'