AutismKB 2.0

Annotation Details for SERPINF2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SERPINF2 ( A2AP,AAP,ALPHA-2-PI,API,PLI )
Gene Full Name: serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Band: 17p13.3
Quick LinksEntrez ID:5345; OMIM: 613168; Uniprot ID:A2AP_HUMAN; ENSEMBL ID: ENSG00000167711; HGNC ID: 9075
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576NAS-extracellular region14718574
GO:0005576TAS-extracellular region-
GO:0005577IDA-fibrinogen complex17317851
GO:0005615IDA-extracellular space6980881
GO:0009986IDA-cell surface17958745
GO:0031093TAS-platelet alpha granule lumen-
GO:0070062IDA-extracellular exosome23376485
GO:0072562IDA-blood microparticle22516433
GO ID Evidence Qualifier GO_term References
GO:0002020IPI-protease binding134998
GO:0004866TAS-endopeptidase inhibitor activity2830248
GO:0004867IDA-serine-type endopeptidase inhibitor activity134998
GO:0004867NAS-serine-type endopeptidase inhibitor activity12878203
GO:0004867TAS-serine-type endopeptidase inhibitor activity-
GO:0005515IPI-protein binding12878203
GO:0042803IPI-protein homodimerization activity134998
GO ID Evidence Qualifier GO_term References
GO:0002034ISS-regulation of blood vessel diameter by renin-angiotensin-
GO:0002576TAS-platelet degranulation-
GO:0006953IEA-acute-phase response-
GO:0010033IEA-response to organic substance-
GO:0010757IDA-negative regulation of plasminogen activation134998
GO:0010951IEA-negative regulation of endopeptidase activity-
GO:0030199ISS-collagen fibril organization17958745
GO:0032967IDA-positive regulation of collagen biosynthetic process17958745
GO:0042730TAS-fibrinolysis-
GO:0045597IDA-positive regulation of cell differentiation20008146
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter17958745
GO:0046330IDA-positive regulation of JNK cascade20008146
GO:0048514ISS-blood vessel morphogenesis-
GO:0048661ISS-positive regulation of smooth muscle cell proliferation-
GO:0051496IDA-positive regulation of stress fiber assembly20008146
GO:0051918IDA-negative regulation of fibrinolysis134998
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade20008146
GO:0071636IDA-positive regulation of transforming growth factor beta production17958745
GO:2000049TAS-positive regulation of cell-cell adhesion mediated by cadherin17203182
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SERPINF2CFD11136012080056 Reconstituted Complex
SERPINF2CFD10803912080056 Reconstituted Complex
SERPINF2ELANE1113602437112 6980881 Biochemical Activity
SERPINF2ELANE1083062437112 6980881 Biochemical Activity
SERPINF2KLK21100179428387 Reconstituted Complex
SERPINF2KLK21113609428387 Reconstituted Complex
SERPINF2PLG111356158022 2437112 Biochemical Activity; Reconstituted Complex
SERPINF2PLG111360158022 2437112 Biochemical Activity; Reconstituted Complex
PRSS1SERPINF21116262437112 Biochemical Activity
PRSS1SERPINF21113602437112 Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
SERPINF2rs1057335, rs2287322, rs736060 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:107173
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060822-1'