AutismKB 2.0

Annotation Details for PLSCR1


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Basic Information Top
Gene Symbol:PLSCR1 ( MMTRA1B )
Gene Full Name: phospholipid scramblase 1
Band: 3q24
Quick LinksEntrez ID:5359; OMIM: 604170; Uniprot ID:PLS1_HUMAN; ENSEMBL ID: ENSG00000188313; HGNC ID: 9092
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus20870722
GO:0005730IDA-nucleolus17567603
GO:0005794IDA-Golgi apparatus12586838
GO:0005829IDA-cytosol17712045
GO:0005886IDA-plasma membrane17712045
GO:0005887IDA-integral component of plasma membrane9218461
GO:0016020IDA-membrane19946888
GO:0031012IDA-extracellular matrix20870722
GO:0045121IDA-membrane raft12009895
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0001077IDA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding16091359
GO:0003677IEA-DNA binding-
GO:0005154IPI-epidermal growth factor receptor binding12009895
GO:0005509IDA-calcium ion binding18629440
GO:0005509NAS-calcium ion binding9218461
GO:0005515IPI-protein binding16189514
GO:0017124IDA-SH3 domain binding11390389
GO:0017128IDA-phospholipid scramblase activity9218461
GO:0019899IPI-enzyme binding12586838
GO:0042609IPI-CD4 receptor binding19333378
GO ID Evidence Qualifier GO_term References
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0006659ISS-phosphatidylserine biosynthetic process-
GO:0006915IDA-apoptotic process10770950
GO:0006953ISS-acute-phase response-
GO:0010628IMP-positive regulation of gene expression15308695
GO:0017121IDA-phospholipid scrambling9218461
GO:0030168NAS-platelet activation9218461
GO:0033003ISS-regulation of mast cell activation-
GO:0035456IMP-response to interferon-beta15308695
GO:0045071IMP-negative regulation of viral genome replication15308695
GO:0045089IMP-positive regulation of innate immune response15308695
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter16091359
GO:0051607IMP-defense response to virus15308695
GO:0060368ISS-regulation of Fc receptor mediated stimulatory signaling pathway-
GO:2000373IDA-positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity17567603
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PLSCR1SLC25A611137316189514 Two-hybrid
PLSCR1SLC25A610679016189514 Two-hybrid
PLSCR1ANXA1110680816189514 Two-hybrid
PLSCR1ANXA1111137316189514 Two-hybrid
PLSCR1CNTFR11137316189514 Two-hybrid
PLSCR1CNTFR10767116189514 Two-hybrid
PLSCR1CRK11137316189514 Two-hybrid
PLSCR1CRK10778816189514 Two-hybrid
PLSCR1CRY110779716189514 Two-hybrid
PLSCR1CRY111137316189514 Two-hybrid
PLSCR1EGFR11137312009895 Affinity Capture-Western; Co-fractionation
PLSCR1EGFR10827612009895 Affinity Capture-Western; Co-fractionation
PLSCR1EWSR110843116189514 Two-hybrid
PLSCR1EWSR111137316189514 Two-hybrid
PLSCR1GNAI210903316189514 Two-hybrid
PLSCR1GNAI211137316189514 Two-hybrid
PLSCR1HOXA110943816189514 Two-hybrid
PLSCR1HOXA111137316189514 Two-hybrid
PLSCR1HOXA910944516189514 Two-hybrid
PLSCR1HOXA911137316189514 Two-hybrid
PLSCR1HOXB611137316189514 Two-hybrid
PLSCR1HOXB610945616189514 Two-hybrid
PLSCR1ILF310982216189514 Two-hybrid
PLSCR1ILF311137316189514 Two-hybrid
PLSCR1LASP111012016189514 Two-hybrid
PLSCR1LASP111137316189514 Two-hybrid
PLSCR1SMCP11035016189514 Two-hybrid
PLSCR1SMCP11137316189514 Two-hybrid
PLSCR1OGDH11101716189514 Two-hybrid
PLSCR1OGDH11137316189514 Two-hybrid
SLPIPLSCR111247510869562 Affinity Capture-Western; Two-hybrid
SLPIPLSCR111137310869562 Affinity Capture-Western; Two-hybrid
SHC1PLSCR111137312009895 12871937 Affinity Capture-Western; Reconstituted Complex
SHC1PLSCR111236112009895 12871937 Affinity Capture-Western; Reconstituted Complex
SRCPLSCR111137312871937 Biochemical Activity
SRCPLSCR111259212871937 Biochemical Activity
TFGPLSCR111137316189514 Affinity Capture-Western; Two-hybrid
TFGPLSCR111562416189514 Affinity Capture-Western; Two-hybrid
CPSF6PLSCR111137316189514 Affinity Capture-Western; Two-hybrid
CPSF6PLSCR111623816189514 Affinity Capture-Western; Two-hybrid
NEU4PLSCR111137316189514 Affinity Capture-Western; Two-hybrid
NEU4PLSCR112620916189514 Affinity Capture-Western; Two-hybrid
SPRY2PLSCR111137316189514 Two-hybrid
SPRY2PLSCR111554716189514 Two-hybrid
GLRX3PLSCR111137316189514 Two-hybrid
GLRX3PLSCR111579316189514 Two-hybrid
C10orf10PLSCR111625116189514 Two-hybrid
C10orf10PLSCR111137316189514 Two-hybrid
CDC42EP1PLSCR111137316189514 Two-hybrid
CDC42EP1PLSCR111630816189514 Two-hybrid
DTX2PLSCR111137316189514 Two-hybrid
DTX2PLSCR112526616189514 Two-hybrid
DHRS1PLSCR111137316189514 Two-hybrid
DHRS1PLSCR112545716189514 Two-hybrid
C12orf12PLSCR111137316189514 Two-hybrid
C12orf12PLSCR112821216189514 Two-hybrid
PHLDA1PLSCR111137316189514 Two-hybrid
PHLDA1PLSCR111649816189514 Two-hybrid
HEY2PLSCR111137316189514 Two-hybrid
HEY2PLSCR111704516189514 Two-hybrid
PGLSPLSCR111137316189514 Two-hybrid
PGLSPLSCR111732816189514 Two-hybrid
YIPF3PLSCR111137316189514 Two-hybrid
YIPF3PLSCR111737016189514 Two-hybrid
ZNF638PLSCR111137316189514 Two-hybrid
ZNF638PLSCR111814516189514 Two-hybrid
LOC284440PLSCR111137316189514 Two-hybrid
LOC284440PLSCR112987816189514 Two-hybrid
EFEMP2PLSCR111137316189514 Two-hybrid
EFEMP2PLSCR111902616189514 Two-hybrid
C10orf62PLSCR111137316189514 Two-hybrid
C10orf62PLSCR113594616189514 Two-hybrid
IP6K2PLSCR111137316189514 Two-hybrid
IP6K2PLSCR111954616189514 Two-hybrid
ZNF581PLSCR111137316189514 Two-hybrid
ZNF581PLSCR111960116189514 Two-hybrid
MED15PLSCR111137316189514 Two-hybrid
MED15PLSCR111962316189514 Two-hybrid
RASD1PLSCR111137316189514 Two-hybrid
RASD1PLSCR111966216189514 Two-hybrid
ADAMTSL4PLSCR111137316189514 Two-hybrid
ADAMTSL4PLSCR112000216189514 Two-hybrid
EXD3PLSCR111137316189514 Two-hybrid
EXD3PLSCR112027216189514 Two-hybrid
CPSF3LPLSCR111137316189514 Two-hybrid
CPSF3LPLSCR112031016189514 Two-hybrid
NECAP2PLSCR111137316189514 Two-hybrid
NECAP2PLSCR112083216189514 Two-hybrid
NPDC1PLSCR111137316189514 Two-hybrid
NPDC1PLSCR112116716189514 Two-hybrid
PLSCR3PLSCR111137316189514 Two-hybrid
PLSCR3PLSCR112134116189514 Two-hybrid
PLSCR4PLSCR111137316189514 Two-hybrid
PLSCR4PLSCR112135716189514 Two-hybrid
NTN4PLSCR111137316189514 Two-hybrid
NTN4PLSCR112186616189514 Two-hybrid
C10orf54PLSCR111137316189514 Two-hybrid
C10orf54PLSCR112207116189514 Two-hybrid
FAM113APLSCR111137316189514 Two-hybrid
FAM113APLSCR112228416189514 Two-hybrid
DLK2PLSCR111137316189514 Two-hybrid
DLK2PLSCR112243816189514 Two-hybrid
SPG7PLSCR111256516189514 Two-hybrid
SPG7PLSCR111137316189514 Two-hybrid
SLC35A2PLSCR111137316189514 Two-hybrid
SLC35A2PLSCR111320216189514 Two-hybrid
VASPPLSCR111137316189514 Two-hybrid
VASPPLSCR111325116189514 Two-hybrid
SF1PLSCR111137316189514 Two-hybrid
SF1PLSCR111336816189514 Two-hybrid
ZBTB16PLSCR111137316189514 Two-hybrid
ZBTB16PLSCR111349816189514 Two-hybrid
NOC4LPLSCR111137316189514 Two-hybrid
NOC4LPLSCR112250816189514 Two-hybrid
FBXL18PLSCR111137316189514 Two-hybrid
FBXL18PLSCR112308016189514 Two-hybrid
CCDC33PLSCR111137316189514 Two-hybrid
CCDC33PLSCR112312616189514 Two-hybrid
KIAA1683PLSCR111137316189514 Two-hybrid
KIAA1683PLSCR112327616189514 Two-hybrid
FAM103A1PLSCR111137316189514 Two-hybrid
FAM103A1PLSCR112370416189514 Two-hybrid
KRTAP4-12PLSCR111137316189514 Two-hybrid
KRTAP4-12PLSCR112375616189514 Two-hybrid
C16orf48PLSCR111137316189514 Two-hybrid
C16orf48PLSCR112387516189514 Two-hybrid
ATG12PLSCR111137316189514 Two-hybrid
ATG12PLSCR111458716189514 Two-hybrid
C4orf42PLSCR111137316189514 Two-hybrid
C4orf42PLSCR112490416189514 Two-hybrid
ZNF764PLSCR111137316189514 Two-hybrid
ZNF764PLSCR112495916189514 Two-hybrid
GPRIN2PLSCR111137316189514 Two-hybrid
GPRIN2PLSCR111507016189514 Two-hybrid
DAZAP2PLSCR111137316189514 Two-hybrid
DAZAP2PLSCR111514316189514 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:893575
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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