AutismKB 2.0

Annotation Details for PLXNA1


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Basic Information Top
Gene Symbol:PLXNA1 ( DKFZp761P19121,NOV,NOVP,PLEXIN-A1,PLXN1 )
Gene Full Name: plexin A1
Band: 3q21.3
Quick LinksEntrez ID:5361; OMIM: 601055; Uniprot ID:PLXA1_HUMAN; ENSEMBL ID: ENSG00000114554; HGNC ID: 9099
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0002116TAS-semaphorin receptor complex19909241
GO:0005886TAS-plasma membrane-
GO:0016021IEA-integral component of membrane-
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0004872TAS-receptor activity8570614
GO:0017154TAS-semaphorin receptor activity10520995
GO ID Evidence Qualifier GO_term References
GO:0007275TAS-multicellular organism development8570614
GO:0014910IEA-regulation of smooth muscle cell migration-
GO:0021785IBA-branchiomotor neuron axon guidance-
GO:0048841IBA-regulation of axon extension involved in axon guidance-
GO:0060666IEA-dichotomous subdivision of terminal units involved in salivary gland branching-
GO:0071526IEA-semaphorin-plexin signaling pathway-
GO:1990138IEA-neuron projection extension-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PLXNA1AKT110671015187088 Reconstituted Complex; Two-hybrid
PLXNA1AKT111137515187088 Reconstituted Complex; Two-hybrid
PLXNA1KDR10999214977921 Affinity Capture-Western
PLXNA1KDR11137514977921 Affinity Capture-Western
PLXNA1NPTX111094411239433 Affinity Capture-Western
PLXNA1NPTX111137511239433 Affinity Capture-Western
PLXNA1PLXNA111137511239433 15187088 Affinity Capture-Western
RHODPLXNA111901011784792 Reconstituted Complex
RHODPLXNA111137511784792 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:107685
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018