AutismKB 2.0

Annotation Details for TLR9


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Basic Information Top
Gene Symbol:TLR9 ( CD289 )
Gene Full Name: toll-like receptor 9
Band: 3p21.2
Quick LinksEntrez ID:54106; OMIM: 605474; Uniprot ID:TLR9_HUMAN; ENSEMBL ID: ENSG00000173366; HGNC ID: 15633
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139TAS-Golgi membrane-
GO:0005576NAS-extracellular region11130078
GO:0005578IBA-proteinaceous extracellular matrix-
GO:0005615IBA-extracellular space-
GO:0005737IDA-cytoplasm19740627
GO:0005764ISS-lysosome-
GO:0005768ISS-endosome-
GO:0005783ISS-endoplasmic reticulum-
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005886IDA-plasma membrane19740627
GO:0010008TAS-endosome membrane-
GO:0016021IEA-integral component of membrane-
GO:0016323IDA-basolateral plasma membrane17128265
GO:0016324IDA-apical plasma membrane17128265
GO:0032009ISS-early phagosome-
GO:0036020TAS-endolysosome membrane-
GO ID Evidence Qualifier GO_term References
GO:0004888IEA-transmembrane signaling receptor activity-
GO:0005149IPI-interleukin-1 receptor binding12925853
GO:0016303TAS-1-phosphatidylinositol-3-kinase activity-
GO:0035197IMP-siRNA binding15723075
GO:0042803ISS-protein homodimerization activity-
GO:0045322ISS-unmethylated CpG binding-
GO ID Evidence Qualifier GO_term References
GO:0002224TAS-toll-like receptor signaling pathway-
GO:0002237TAS-response to molecule of bacterial origin15356140
GO:0002755IEA-MyD88-dependent toll-like receptor signaling pathway-
GO:0006954IEA-inflammatory response-
GO:0007252IDA-I-kappaB phosphorylation19740627
GO:0007409IBA-axonogenesis-
GO:0010628IDA-positive regulation of gene expression24409285
GO:0030277ISS-maintenance of gastrointestinal epithelium-
GO:0032088IDA-negative regulation of NF-kappaB transcription factor activity17128265
GO:0032640IDA-tumor necrosis factor production23826189
GO:0032715ISS-negative regulation of interleukin-6 production-
GO:0032717IDA-negative regulation of interleukin-8 production17128265
GO:0032722IDA-positive regulation of chemokine production19740627
GO:0032725IDA-positive regulation of granulocyte macrophage colony-stimulating factor production24409285
GO:0032728ISS-positive regulation of interferon-beta production-
GO:0032733ISS-positive regulation of interleukin-10 production-
GO:0032735ISS-positive regulation of interleukin-12 production-
GO:0032741ISS-positive regulation of interleukin-18 production-
GO:0032755IDA-positive regulation of interleukin-6 production19740627
GO:0032757IDA-positive regulation of interleukin-8 production17128265
GO:0032760ISS-positive regulation of tumor necrosis factor production-
GO:0034122IDA-negative regulation of toll-like receptor signaling pathway17128265
GO:0034123IDA-positive regulation of toll-like receptor signaling pathway17128265
GO:0034162TAS-toll-like receptor 9 signaling pathway-
GO:0036092IEA-phosphatidylinositol-3-phosphate biosynthetic process-
GO:0042346IDA-positive regulation of NF-kappaB import into nucleus19740627
GO:0042742NAS-defense response to bacterium11130078
GO:0043123IDA-positive regulation of I-kappaB kinase/NF-kappaB signaling17128265
GO:0043507IDA-positive regulation of JUN kinase activity17128265
GO:0045078IDA-positive regulation of interferon-gamma biosynthetic process16286015
GO:0045087TAS-innate immune response15356140
GO:0045356IDA-positive regulation of interferon-alpha biosynthetic process16286015
GO:0045359IDA-positive regulation of interferon-beta biosynthetic process16286015
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0046330IC-positive regulation of JNK cascade17128265
GO:0050707IEA-regulation of cytokine secretion-
GO:0050729IC-positive regulation of inflammatory response19740627
GO:0050829IMP-defense response to Gram-negative bacterium22427638
GO:0051092IDA-positive regulation of NF-kappaB transcription factor activity17128265
GO:0051770ISS-positive regulation of nitric-oxide synthase biosynthetic process-
GO:1901895IDA-negative regulation of calcium-transporting ATPase activity24610369
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TLR9MYD8811990215107846 Two-hybrid
TLR9MYD8811070015107846 Two-hybrid
RNF216TLR911990215107846 Two-hybrid
RNF216TLR911998115107846 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1932389
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040219-10'