Annotation Details for POLA1
Basic Information Top
Gene Symbol: | POLA1 ( DKFZp686K1672,POLA,p180 ) |
---|---|
Gene Full Name: | polymerase (DNA directed), alpha 1, catalytic subunit |
Band: | Xp22.11-p21.3 |
Quick Links | Entrez ID:5422; OMIM: 312040; Uniprot ID:DPOLA_HUMAN; ENSEMBL ID: ENSG00000101868; HGNC ID: 9173 |
Relate to Another Database: | SFARIGene; denovo-db |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0000785 | IDA | colocalizes_with | chromatin | 9815285 |
GO:0005634 | IDA | - | nucleus | 4084590 |
GO:0005635 | IDA | - | nuclear envelope | 9518481 |
GO:0005654 | IDA | - | nucleoplasm | 7045121 |
GO:0005654 | TAS | - | nucleoplasm | - |
GO:0005658 | IDA | - | alpha DNA polymerase:primase complex | 2175912 |
GO:0005658 | TAS | - | alpha DNA polymerase:primase complex | 2243771 |
GO:0005730 | IDA | - | nucleolus | 9518481 |
GO:0005829 | IDA | - | cytosol | - |
GO:0016363 | IDA | - | nuclear matrix | 1903085 |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0000166 | IDA | - | nucleotide binding | 3139084 |
GO:0001882 | IEA | - | nucleoside binding | - |
GO:0003677 | IDA | - | DNA binding | 16762037 |
GO:0003677 | NAS | - | DNA binding | 3359994 |
GO:0003682 | IDA | - | chromatin binding | 16762037 |
GO:0003887 | IDA | - | DNA-directed DNA polymerase activity | 893425 |
GO:0003887 | IMP | - | DNA-directed DNA polymerase activity | 4084590 |
GO:0005515 | IPI | - | protein binding | 1311258 |
GO:0008408 | IEA | - | 3'-5' exonuclease activity | - |
GO:0019901 | IPI | - | protein kinase binding | 9506968 |
GO:0046872 | IEA | - | metal ion binding | - |
GO:0051539 | IEA | - | 4 iron, 4 sulfur cluster binding | - |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0000082 | TAS | - | G1/S transition of mitotic cell cycle | - |
GO:0000083 | TAS | - | regulation of transcription involved in G1/S transition of mitotic cell cycle | - |
GO:0000722 | TAS | - | telomere maintenance via recombination | - |
GO:0000731 | IMP | NOT | DNA synthesis involved in DNA repair | 1508673 |
GO:0006260 | IMP | - | DNA replication | 3917431 |
GO:0006269 | IDA | - | DNA replication, synthesis of RNA primer | 2175912 |
GO:0006270 | IDA | - | DNA replication initiation | 2175912 |
GO:0006270 | TAS | - | DNA replication initiation | - |
GO:0006271 | IMP | - | DNA strand elongation involved in DNA replication | 4084590 |
GO:0006272 | IDA | - | leading strand elongation | 2175912 |
GO:0006273 | IDA | - | lagging strand elongation | 2175912 |
GO:0006281 | IDA | NOT | DNA repair | 3335506 |
GO:0006303 | IMP | - | double-strand break repair via nonhomologous end joining | 11470886 |
GO:0008283 | IDA | - | cell proliferation | 3359994 |
GO:0016032 | IEA | - | viral process | - |
GO:0090305 | IEA | - | nucleic acid phosphodiester bond hydrolysis | - |
Gene Symbol | Interactant | Interaction ID | References | Description |
---|---|---|---|---|
POLA1 | PARP1 | 106652 | 9518481 | Affinity Capture-Western; Far Western |
POLA1 | PARP1 | 111418 | 9518481 | Affinity Capture-Western; Far Western |
POLA1 | CDK2 | 111418 | 10877824 | Biochemical Activity |
POLA1 | CDK2 | 107452 | 10877824 | Biochemical Activity |
POLA1 | CHEK1 | 107536 | 19177015 | Affinity Capture-Western |
POLA1 | CHEK1 | 111418 | 19177015 | Affinity Capture-Western |
POLA2 | POLA1 | 117176 | 8223465 | Reconstituted Complex |
POLA2 | POLA1 | 111418 | 8223465 | Reconstituted Complex |
RB1 | POLA1 | 111418 | 9395244 | Affinity Capture-Western; Co-purification |
RB1 | POLA1 | 111860 | 9395244 | Affinity Capture-Western; Co-purification |
CDC45 | POLA1 | 111418 | 10518787 | Reconstituted Complex |
CDC45 | POLA1 | 113915 | 10518787 | Reconstituted Complex |
RBMS1 | POLA1 | 111872 | 10869558 | Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid |
RBMS1 | POLA1 | 111418 | 10869558 | Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid |
CDK2AP1 | POLA1 | 113770 | 10877824 | Reconstituted Complex |
CDK2AP1 | POLA1 | 111418 | 10877824 | Reconstituted Complex |
TP53 | POLA1 | 113010 | 11917009 | Affinity Capture-Western |
TP53 | POLA1 | 111418 | 11917009 | Affinity Capture-Western |
HELB | POLA1 | 124978 | 12181327 | Reconstituted Complex |
HELB | POLA1 | 111418 | 12181327 | Reconstituted Complex |
XRCC5 | POLA1 | 111418 | 12393188 | Affinity Capture-Western |
XRCC5 | POLA1 | 113353 | 12393188 | Affinity Capture-Western |
RAE1 | POLA1 | 111418 | 19615732 | Affinity Capture-MS |
RAE1 | POLA1 | 114054 | 19615732 | Affinity Capture-MS |
No data |
No data |
- MGI ID: MGI:99660
- Data Attributes: MGI curated and HomoloGene calculated
- ZFIN ID: ZDB-GENE-030114-9