AutismKB 2.0

Annotation Details for POLA1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:POLA1 ( DKFZp686K1672,POLA,p180 )
Gene Full Name: polymerase (DNA directed), alpha 1, catalytic subunit
Band: Xp22.11-p21.3
Quick LinksEntrez ID:5422; OMIM: 312040; Uniprot ID:DPOLA_HUMAN; ENSEMBL ID: ENSG00000101868; HGNC ID: 9173
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000785IDAcolocalizes_withchromatin9815285
GO:0005634IDA-nucleus4084590
GO:0005635IDA-nuclear envelope9518481
GO:0005654IDA-nucleoplasm7045121
GO:0005654TAS-nucleoplasm-
GO:0005658IDA-alpha DNA polymerase:primase complex2175912
GO:0005658TAS-alpha DNA polymerase:primase complex2243771
GO:0005730IDA-nucleolus9518481
GO:0005829IDA-cytosol-
GO:0016363IDA-nuclear matrix1903085
GO ID Evidence Qualifier GO_term References
GO:0000166IDA-nucleotide binding3139084
GO:0001882IEA-nucleoside binding-
GO:0003677IDA-DNA binding16762037
GO:0003677NAS-DNA binding3359994
GO:0003682IDA-chromatin binding16762037
GO:0003887IDA-DNA-directed DNA polymerase activity893425
GO:0003887IMP-DNA-directed DNA polymerase activity4084590
GO:0005515IPI-protein binding1311258
GO:0008408IEA-3'-5' exonuclease activity-
GO:0019901IPI-protein kinase binding9506968
GO:0046872IEA-metal ion binding-
GO:0051539IEA-4 iron, 4 sulfur cluster binding-
GO ID Evidence Qualifier GO_term References
GO:0000082TAS-G1/S transition of mitotic cell cycle-
GO:0000083TAS-regulation of transcription involved in G1/S transition of mitotic cell cycle-
GO:0000722TAS-telomere maintenance via recombination-
GO:0000731IMPNOTDNA synthesis involved in DNA repair1508673
GO:0006260IMP-DNA replication3917431
GO:0006269IDA-DNA replication, synthesis of RNA primer2175912
GO:0006270IDA-DNA replication initiation2175912
GO:0006270TAS-DNA replication initiation-
GO:0006271IMP-DNA strand elongation involved in DNA replication4084590
GO:0006272IDA-leading strand elongation2175912
GO:0006273IDA-lagging strand elongation2175912
GO:0006281IDANOTDNA repair3335506
GO:0006303IMP-double-strand break repair via nonhomologous end joining11470886
GO:0008283IDA-cell proliferation3359994
GO:0016032IEA-viral process-
GO:0090305IEA-nucleic acid phosphodiester bond hydrolysis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
POLA1PARP11066529518481 Affinity Capture-Western; Far Western
POLA1PARP11114189518481 Affinity Capture-Western; Far Western
POLA1CDK211141810877824 Biochemical Activity
POLA1CDK210745210877824 Biochemical Activity
POLA1CHEK110753619177015 Affinity Capture-Western
POLA1CHEK111141819177015 Affinity Capture-Western
POLA2POLA11171768223465 Reconstituted Complex
POLA2POLA11114188223465 Reconstituted Complex
RB1POLA11114189395244 Affinity Capture-Western; Co-purification
RB1POLA11118609395244 Affinity Capture-Western; Co-purification
CDC45POLA111141810518787 Reconstituted Complex
CDC45POLA111391510518787 Reconstituted Complex
RBMS1POLA111187210869558 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
RBMS1POLA111141810869558 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
CDK2AP1POLA111377010877824 Reconstituted Complex
CDK2AP1POLA111141810877824 Reconstituted Complex
TP53POLA111301011917009 Affinity Capture-Western
TP53POLA111141811917009 Affinity Capture-Western
HELBPOLA112497812181327 Reconstituted Complex
HELBPOLA111141812181327 Reconstituted Complex
XRCC5POLA111141812393188 Affinity Capture-Western
XRCC5POLA111335312393188 Affinity Capture-Western
RAE1POLA111141819615732 Affinity Capture-MS
RAE1POLA111405419615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99660
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030114-9'