Annotation Details for POLE
Basic Information Top
| Gene Symbol: | POLE ( DKFZp434F222,FLJ21434,POLE1 ) |
|---|---|
| Gene Full Name: | polymerase (DNA directed), epsilon |
| Band: | 12q24.33 |
| Quick Links | Entrez ID:5426; OMIM: 174762; Uniprot ID:DPOE1_HUMAN; ENSEMBL ID: ENSG00000177084; HGNC ID: 9177 |
| Relate to Another Database: | SFARIGene; denovo-db |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0005634 | IDA | - | nucleus | 16762037 |
| GO:0005654 | IDA | - | nucleoplasm | - |
| GO:0005654 | TAS | - | nucleoplasm | - |
| GO:0005886 | IDA | - | plasma membrane | - |
| GO:0008622 | IDA | - | epsilon DNA polymerase complex | 10801849 |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0000166 | IEA | - | nucleotide binding | - |
| GO:0003677 | IDA | - | DNA binding | 16762037 |
| GO:0003682 | IDA | - | chromatin binding | 16762037 |
| GO:0003887 | IMP | - | DNA-directed DNA polymerase activity | 16762037 |
| GO:0005515 | IPI | - | protein binding | 10801849 |
| GO:0008270 | IEA | - | zinc ion binding | - |
| GO:0008310 | IBA | - | single-stranded DNA 3'-5' exodeoxyribonuclease activity | - |
| GO:0051539 | IEA | - | 4 iron, 4 sulfur cluster binding | - |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0000082 | IMP | - | G1/S transition of mitotic cell cycle | 16762037 |
| GO:0000082 | TAS | - | G1/S transition of mitotic cell cycle | - |
| GO:0000722 | TAS | - | telomere maintenance via recombination | - |
| GO:0000731 | IMP | - | DNA synthesis involved in DNA repair | 1730053 |
| GO:0006260 | IMP | - | DNA replication | 16762037 |
| GO:0006270 | TAS | - | DNA replication initiation | - |
| GO:0006272 | IBA | - | leading strand elongation | - |
| GO:0006287 | IDA | - | base-excision repair, gap-filling | 10559260 |
| GO:0006297 | IMP | - | nucleotide-excision repair, DNA gap filling | 20227374 |
| GO:0045004 | IBA | - | DNA replication proofreading | - |
| GO:0048568 | IEA | - | embryonic organ development | - |
| GO:0090305 | IEA | - | nucleic acid phosphodiester bond hydrolysis | - |
| Gene Symbol | Interactant | Interaction ID | References | Description |
|---|---|---|---|---|
| POLE | MYC | 111422 | 17353931 | Affinity Capture-MS |
| POLE | MYC | 110694 | 17353931 | Affinity Capture-MS |
| POLE | PCNA | 111142 | 12171929 | Affinity Capture-MS |
| POLE | PCNA | 111422 | 12171929 | Affinity Capture-MS |
| TOPBP1 | POLE | 116256 | 11395493 | Affinity Capture-Western |
| TOPBP1 | POLE | 111422 | 11395493 | Affinity Capture-Western |
| RAD17 | POLE | 111821 | 14500819 | Affinity Capture-Western; Reconstituted Complex |
| RAD17 | POLE | 111422 | 14500819 | Affinity Capture-Western; Reconstituted Complex |
| STK19 | POLE | 111422 | 14667819 | Two-hybrid |
| STK19 | POLE | 114383 | 14667819 | Two-hybrid |
| No data |
| No data |
- MGI ID: MGI:1196391
- Data Attributes: MGI curated and HomoloGene calculated
- ZFIN ID: ZDB-GENE-070705-557



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