AutismKB 2.0

Annotation Details for POLR2A


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Basic Information Top
Gene Symbol:POLR2A ( MGC75453,POLR2,POLRA,RPB1,RPBh1,RPO2,RPOL2,RpIILS,hRPB220,hsRPB1 )
Gene Full Name: polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
Band: 17p13.1
Quick LinksEntrez ID:5430; OMIM: 180660; Uniprot ID:RPB1_HUMAN; ENSEMBL ID: ENSG00000181222; HGNC ID: 9187
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000974IDAcolocalizes_withPrp19 complex21536736
GO:0005634IDA-nucleus9852112
GO:0005634NAS-nucleus7622068
GO:0005654TAS-nucleoplasm-
GO:0005665IDA-DNA-directed RNA polymerase II, core complex9852112
GO:0005730IDANOTnucleolus16109376
GO ID Evidence Qualifier GO_term References
GO:0001055IBAcontributes_toRNA polymerase II activity-
GO:0003677NAS-DNA binding7622068
GO:0003723IDA-RNA binding22658674
GO:0003899NAS-DNA-directed 5'-3' RNA polymerase activity7622068
GO:0003968IEA-RNA-directed 5'-3' RNA polymerase activity-
GO:0005515IPI-protein binding10075709
GO:0005515IPIcontributes_toprotein binding16239144
GO:0031625IPI-ubiquitin protein ligase binding17996703
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000398TAS-mRNA splicing, via spliceosome-
GO:0001172IEA-transcription, RNA-templated-
GO:0006283TAS-transcription-coupled nucleotide-excision repair-
GO:0006351TAS-transcription, DNA-templated-
GO:0006353IMP-DNA-templated transcription, termination26700805
GO:0006355NAS-regulation of transcription, DNA-templated7622068
GO:0006366IDA-transcription from RNA polymerase II promoter9852112
GO:0006366NAS-transcription from RNA polymerase II promoter7622068
GO:0006366TAS-transcription from RNA polymerase II promoter-
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0006368TAS-transcription elongation from RNA polymerase II promoter-
GO:0006370TAS-7-methylguanosine mRNA capping-
GO:0008543TAS-fibroblast growth factor receptor signaling pathway-
GO:0016070TAS-RNA metabolic process-
GO:0033120IDA-positive regulation of RNA splicing21536736
GO:0035019TAS-somatic stem cell population maintenance-
GO:0042795TAS-snRNA transcription from RNA polymerase II promoter-
GO:0050434TAS-positive regulation of viral transcription-
GO:0060964TAS-regulation of gene silencing by miRNA-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
POLR2AAIRE10682320085707 Affinity Capture-MS
POLR2AAIRE11142620085707 Affinity Capture-MS
POLR2ABRCA11071409159119 11504724 12955082 14506230 15886201 Affinity Capture-Western; Biochemical Activity; Co-purification
POLR2ABRCA11114269159119 11504724 12955082 14506230 15886201 Affinity Capture-Western; Biochemical Activity; Co-purification
POLR2ACDK81074589710619 Affinity Capture-Western; Co-fractionation
POLR2ACDK81114269710619 Affinity Capture-Western; Co-fractionation
POLR2ACDK910745916735508 Biochemical Activity
POLR2ACDK911142616735508 Biochemical Activity
POLR2ACREBBP1077779710619 Affinity Capture-Western; Co-fractionation
POLR2ACREBBP1114269710619 Affinity Capture-Western; Co-fractionation
POLR2ACSH21078309312053 Affinity Capture-Western; Co-fractionation
POLR2ACSH21114269312053 Affinity Capture-Western; Co-fractionation
POLR2ADDX510802117011493 Affinity Capture-Western
POLR2ADDX511142617011493 Affinity Capture-Western
POLR2AEP3001083479710619 Affinity Capture-Western
POLR2AEP3001114269710619 Affinity Capture-Western
POLR2AFCP111142614576433 Reconstituted Complex
POLR2AFCP110851514576433 Reconstituted Complex
POLR2AGTF2B1092149159119 17643375 Affinity Capture-MS; Co-purification; Reconstituted Complex
POLR2AGTF2B1114269159119 17643375 Affinity Capture-MS; Co-purification; Reconstituted Complex
POLR2AGTF2E11114267926747 9159119 Co-purification; Reconstituted Complex
POLR2AGTF2E11092157926747 9159119 Co-purification; Reconstituted Complex
POLR2AGTF2E210921612665589 Affinity Capture-Western
POLR2AGTF2E211142612665589 Affinity Capture-Western
POLR2AGTF2F11092179159119 9710619 17643375 Affinity Capture-MS; Co-fractionation; Co-purification; Reconstituted Complex
POLR2AGTF2F11114269159119 9710619 17643375 Affinity Capture-MS; Co-fractionation; Co-purification; Reconstituted Complex
POLR2AGTF2F21092183860504 17643375 Affinity Capture-MS; Co-purification
POLR2AGTF2F21114263860504 17643375 Affinity Capture-MS; Co-purification
POLR2AGTF2H41114269159119 Co-purification; Reconstituted Complex
POLR2AGTF2H41092239159119 Co-purification; Reconstituted Complex
POLR2AH2AFX10926815613478 Affinity Capture-Western
POLR2AH2AFX11142615613478 Affinity Capture-Western
POLR2AHNRNPU10943310490622 Affinity Capture-Western
POLR2AHNRNPU11142610490622 Affinity Capture-Western
POLR2AMEN111038416199523 17050672 Affinity Capture-Western; Co-localization; Reconstituted Complex
POLR2AMEN111142616199523 17050672 Affinity Capture-Western; Co-localization; Reconstituted Complex
POLR2AMLL11044316199523 Affinity Capture-Western; Co-localization; Reconstituted Complex
POLR2AMLL11142616199523 Affinity Capture-Western; Co-localization; Reconstituted Complex
POLR2AMYC11069412660246 Reconstituted Complex
POLR2AMYC11142612660246 Reconstituted Complex
POLR2ANEDD411081116055720 17996703 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
POLR2ANEDD411142616055720 17996703 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
POLR2ANF111142615999204 Affinity Capture-Western
POLR2ANF111083615999204 Affinity Capture-Western
POLR2ANFKB111085716319923 Co-localization
POLR2ANFKB111142616319923 Co-localization
POLR2APIN111131710393805 Affinity Capture-Western
POLR2APIN111142610393805 Affinity Capture-Western
SMARCA4POLR2A1124818895581 9128241 9845365 11238380 15999204 16195385 Affinity Capture-Western; Co-fractionation; Co-localization; Co-purification
SMARCA4POLR2A1114268895581 9128241 9845365 11238380 15999204 16195385 Affinity Capture-Western; Co-fractionation; Co-localization; Co-purification
SMARCA2POLR2A1124798895581 9710619 11238380 16341228 Co-fractionation; Co-localization; Co-purification
SMARCA2POLR2A1114268895581 9710619 11238380 16341228 Co-fractionation; Co-localization; Co-purification
SMARCB1POLR2A1124828895581 9710619 11238380 Co-fractionation; Co-purification
SMARCB1POLR2A1114268895581 9710619 11238380 Co-fractionation; Co-purification
MED21POLR2A1114269159119 9315662 9710619 Affinity Capture-Western; Co-fractionation; Co-purification
MED21POLR2A1148079159119 9315662 9710619 Affinity Capture-Western; Co-fractionation; Co-purification
CTDP1POLR2A1145979159119 Affinity Capture-Western; Co-purification; Reconstituted Complex
CTDP1POLR2A1114269159119 Affinity Capture-Western; Co-purification; Reconstituted Complex
TAF11POLR2A1127459159119 Co-purification; Reconstituted Complex
TAF11POLR2A1114269159119 Co-purification; Reconstituted Complex
TBPPOLR2A1114269159119 Co-purification; Reconstituted Complex
TBPPOLR2A1127719159119 Co-purification; Reconstituted Complex
POLR2CPOLR2A1114289201987 19240132 Reconstituted Complex
POLR2CPOLR2A1114269201987 19240132 Reconstituted Complex
POLR2EPOLR2A1114309201987 19240132 Reconstituted Complex
POLR2EPOLR2A1114269201987 19240132 Reconstituted Complex
POLR2FPOLR2A1114269201987 19240132 Reconstituted Complex
POLR2FPOLR2A1114319201987 19240132 Reconstituted Complex
POLR2GPOLR2A1114269201987 19240132 Reconstituted Complex
POLR2GPOLR2A1114329201987 19240132 Reconstituted Complex
POLR2HPOLR2A1114339201987 19240132 Reconstituted Complex
POLR2HPOLR2A1114269201987 19240132 Reconstituted Complex
POLR2KPOLR2A1114369201987 Reconstituted Complex
POLR2KPOLR2A1114269201987 Reconstituted Complex
POLR2LPOLR2A1114379201987 Reconstituted Complex
POLR2LPOLR2A1114269201987 Reconstituted Complex
TCEA1POLR2A1127799305922 9765293 12914699 17643375 Affinity Capture-MS; Co-crystal Structure; Reconstituted Complex
TCEA1POLR2A1114269305922 9765293 12914699 17643375 Affinity Capture-MS; Co-crystal Structure; Reconstituted Complex
ZNF74POLR2A1114269346935 Affinity Capture-Western; Far Western
ZNF74POLR2A1134449346935 Affinity Capture-Western; Far Western
SUPT5HPOLR2A1126979450929 10454543 Affinity Capture-Western
SUPT5HPOLR2A1114269450929 10454543 Affinity Capture-Western
CCNKPOLR2A1143399632813 Affinity Capture-Western
CCNKPOLR2A1114269632813 Affinity Capture-Western
KAT2BPOLR2A1114269710619 Affinity Capture-Western
KAT2BPOLR2A1143759710619 Affinity Capture-Western
HTATSF1POLR2A11142610454543 Affinity Capture-Western
HTATSF1POLR2A11814910454543 Affinity Capture-Western
TCERG1POLR2A11612010908677 17218272 Affinity Capture-MS; Affinity Capture-Western; Far Western
TCERG1POLR2A11142610908677 17218272 Affinity Capture-MS; Affinity Capture-Western; Far Western
XAB2POLR2A12127310944529 Affinity Capture-Western
XAB2POLR2A11142610944529 Affinity Capture-Western
ELP3POLR2A11142611714725 Co-purification
ELP3POLR2A12044411714725 Co-purification
PQBP1POLR2A11142612062018 Affinity Capture-Western; Reconstituted Complex
PQBP1POLR2A11539312062018 Affinity Capture-Western; Reconstituted Complex
NR0B2POLR2A11142612198243 Reconstituted Complex
NR0B2POLR2A11401212198243 Reconstituted Complex
SND1POLR2A11142612234934 Affinity Capture-Western; Reconstituted Complex
SND1POLR2A11797412234934 Affinity Capture-Western; Reconstituted Complex
PCIF1POLR2A11142612565871 Affinity Capture-Western; Reconstituted Complex
PCIF1POLR2A12200312565871 Affinity Capture-Western; Reconstituted Complex
UBCPOLR2A11316412604794 18285459 Affinity Capture-Western
UBCPOLR2A11142612604794 18285459 Affinity Capture-Western
VHLPOLR2A11326912604794 18285459 Affinity Capture-Western; Protein-peptide
VHLPOLR2A11142612604794 18285459 Affinity Capture-Western; Protein-peptide
RDBPPOLR2A11142612612062 Affinity Capture-Western
RDBPPOLR2A11366212612062 Affinity Capture-Western
WHSC2POLR2A11330712612062 Reconstituted Complex
WHSC2POLR2A11142612612062 Reconstituted Complex
CTDSP2POLR2A11142612721286 Biochemical Activity
CTDSP2POLR2A11541212721286 Biochemical Activity
CTDSP1POLR2A11142612721286 Biochemical Activity
CTDSP1POLR2A12180412721286 Biochemical Activity
MDC1POLR2A11142614578343 Protein-peptide
MDC1POLR2A11501414578343 Protein-peptide
CCNL2POLR2A11142614684736 Affinity Capture-Western
CCNL2POLR2A12356614684736 Affinity Capture-Western
TAF10POLR2A11274415099517 Affinity Capture-Western
TAF10POLR2A11142615099517 Affinity Capture-Western
MED19POLR2A12855315175163 Affinity Capture-MS
MED19POLR2A11142615175163 Affinity Capture-MS
MED9POLR2A11142615175163 Affinity Capture-MS
MED9POLR2A12040315175163 Affinity Capture-MS
MED29POLR2A12073415175163 Affinity Capture-MS
MED29POLR2A11142615175163 Affinity Capture-MS
MED28POLR2A11142615175163 Affinity Capture-MS
MED28POLR2A12321915175163 Affinity Capture-MS
MED10POLR2A11142615175163 Affinity Capture-MS; Affinity Capture-Western
MED10POLR2A12397415175163 Affinity Capture-MS; Affinity Capture-Western
MED26POLR2A11142615175163 Affinity Capture-MS; Affinity Capture-Western
MED26POLR2A11483115175163 Affinity Capture-MS; Affinity Capture-Western
SMYD3POLR2A12226815235609 Affinity Capture-Western
SMYD3POLR2A11142615235609 Affinity Capture-Western
CDC73POLR2A12272415632063 Affinity Capture-Western
CDC73POLR2A11142615632063 Affinity Capture-Western
RXRAPOLR2A11142615863722 Co-localization
RXRAPOLR2A11216815863722 Co-localization
VDRPOLR2A11142615890193 15919092 Co-localization
VDRPOLR2A11326415890193 15919092 Co-localization
MED1POLR2A11146515989967 Affinity Capture-Western
MED1POLR2A11142615989967 Affinity Capture-Western
MED30POLR2A11142615989967 Affinity Capture-Western
MED30POLR2A12470715989967 Affinity Capture-Western
WWOXPOLR2A11142616055720 Affinity Capture-MS
WWOXPOLR2A11970716055720 Affinity Capture-MS
ITCHPOLR2A11142616055720 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
ITCHPOLR2A12374716055720 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CBX3POLR2A11142616061184 Affinity Capture-Western
CBX3POLR2A11646316061184 Affinity Capture-Western
SETD2POLR2A11142616118227 Affinity Capture-Western; Reconstituted Complex
SETD2POLR2A11884516118227 Affinity Capture-Western; Reconstituted Complex
MLL2POLR2A11375816199523 Reconstituted Complex
MLL2POLR2A11142616199523 Reconstituted Complex
PAF1POLR2A11142616491129 Affinity Capture-Western
PAF1POLR2A12008116491129 Affinity Capture-Western
EIF2C1POLR2A11142616936726 Affinity Capture-Western
EIF2C1POLR2A11772616936726 Affinity Capture-Western
CTCFPOLR2A11142617210645 Affinity Capture-Western; Co-purification; Reconstituted Complex
CTCFPOLR2A11590617210645 Affinity Capture-Western; Co-purification; Reconstituted Complex
GPN1POLR2A11142617643375 Affinity Capture-MS
GPN1POLR2A11645217643375 Affinity Capture-MS
RPAP3POLR2A12278317643375 Affinity Capture-MS
RPAP3POLR2A11142617643375 Affinity Capture-MS
RPAP2POLR2A12295917643375 Affinity Capture-MS
RPAP2POLR2A11142617643375 Affinity Capture-MS
UBA1POLR2A11316517996703 Reconstituted Complex
UBA1POLR2A11142617996703 Reconstituted Complex
UBE2L3POLR2A11318017996703 Reconstituted Complex
UBE2L3POLR2A11142617996703 Reconstituted Complex
SETD1BPOLR2A11670217998332 Affinity Capture-Western
SETD1BPOLR2A11142617998332 Affinity Capture-Western
SETD1APOLR2A11508817998332 Affinity Capture-Western
SETD1APOLR2A11142617998332 Affinity Capture-Western
EGLN2POLR2A11142618285459 Affinity Capture-Western
EGLN2POLR2A12518418285459 Affinity Capture-Western
EGLN1POLR2A11142618285459 Affinity Capture-Western
EGLN1POLR2A12006018285459 Affinity Capture-Western
ATF7IPPOLR2A12084919106100 Affinity Capture-Western
ATF7IPPOLR2A11142619106100 Affinity Capture-Western
SUPT6HPOLR2A11269819141475 Far Western
SUPT6HPOLR2A11142619141475 Far Western
IWS1POLR2A11142619141475 Reconstituted Complex
IWS1POLR2A12080719141475 Reconstituted Complex
SSRP1POLR2A11262719214185 Affinity Capture-Western
SSRP1POLR2A11142619214185 Affinity Capture-Western
POLR2BPOLR2A11142719240132 Reconstituted Complex
POLR2BPOLR2A11142619240132 Reconstituted Complex
POLR2IPOLR2A11142619240132 Reconstituted Complex
POLR2IPOLR2A11143419240132 Reconstituted Complex
POLR2JPOLR2A11142619240132 Reconstituted Complex
POLR2JPOLR2A11143519240132 Reconstituted Complex
RECQL5POLR2A11479719270065 Affinity Capture-MS
RECQL5POLR2A11142619270065 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98086
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041008-78'