AutismKB 2.0

Annotation Details for NLGN3


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Basic Information Top
Gene Symbol:NLGN3 ( HNL3,KIAA1480 )
Gene Full Name: neuroligin 3
Band: Xq13.1
Quick LinksEntrez ID:54413; OMIM: 300336; Uniprot ID:NLGN3_HUMAN; ENSEMBL ID: ENSG00000196338; HGNC ID: 14289
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0005887IBA-integral component of plasma membrane-
GO:0009986IDA-cell surface15150161
GO:0030054IEA-cell junction-
GO:0030139ISS-endocytic vesicle-
GO:0045202ISS-synapse-
GO:0060076IDA-excitatory synapse15620359
GO:0099055ISS-integral component of postsynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0004872IBA-receptor activity-
GO:0004872ISS-receptor activity-
GO:0005515IPI-protein binding17292328
GO:0042043IBA-neurexin family protein binding-
GO:0042043ISS-neurexin family protein binding15152050
GO:0050839ISS-cell adhesion molecule binding15152050
GO:0052689IBA-carboxylic ester hydrolase activity-
GO:0097110IPI-scaffold protein binding17292328
GO ID Evidence Qualifier GO_term References
GO:0002087ISS-regulation of respiratory gaseous exchange by neurological system process-
GO:0006898ISS-receptor-mediated endocytosis-
GO:0007158IBA-neuron cell-cell adhesion-
GO:0007158ISS-neuron cell-cell adhesion-
GO:0007416IBA-synapse assembly-
GO:0007416ISS-synapse assembly-
GO:0007612IMP-learning12669065
GO:0008542IEA-visual learning-
GO:0030534IMP-adult behavior12669065
GO:0035176IMP-social behavior12669065
GO:0048675ISS-axon extension-
GO:0048709IEA-oligodendrocyte differentiation-
GO:0050804IBA-modulation of synaptic transmission-
GO:0050804ISS-modulation of synaptic transmission-
GO:0050808IMP-synapse organization15150161
GO:0051965ISS-positive regulation of synapse assembly-
GO:0051968ISS-positive regulation of synaptic transmission, glutamatergic-
GO:0060024ISS-rhythmic synaptic transmission-
GO:0060079IEA-excitatory postsynaptic potential-
GO:0060080ISS-inhibitory postsynaptic potential-
GO:0060291IEA-long-term synaptic potentiation-
GO:0061002IEA-negative regulation of dendritic spine morphogenesis-
GO:0071625IMP-vocalization behavior12669065
GO:0090394IEA-negative regulation of excitatory postsynaptic potential-
GO:0097104ISS-postsynaptic membrane assembly-
GO:0097105ISS-presynaptic membrane assembly-
GO:1900271IEA-regulation of long-term synaptic potentiation-
GO:2000310IEA-regulation of NMDA receptor activity-
GO:2000331IEA-regulation of terminal button organization-
GO:2000463ISS-positive regulation of excitatory postsynaptic potential-
GO:2000809IEA-positive regulation of synaptic vesicle clustering-
GO:2000969ISS-positive regulation of AMPA receptor activity-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NLGN3DLG21080849278515 Two-hybrid
NLGN3DLG21199449278515 Two-hybrid
NLGN3DLG31199449278515 Two-hybrid
NLGN3DLG31080859278515 Two-hybrid
NLGN3DLG41199449278515 Two-hybrid
NLGN3DLG41080869278515 Two-hybrid
NLGN3NRXN31147708576240 Reconstituted Complex
NLGN3NRXN31199448576240 Reconstituted Complex
NLGN3NRXN11147798576240 Reconstituted Complex
NLGN3NRXN11199448576240 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2444609
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060526-197'