AutismKB 2.0

Annotation Details for POMC


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Basic Information Top
Gene Symbol:POMC ( ACTH,CLIP,LPH,MSH,NPP,POC )
Gene Full Name: proopiomelanocortin
Band: 2p23.3
Quick LinksEntrez ID:5443; OMIM: 176830; Uniprot ID:COLI_HUMAN; ENSEMBL ID: ENSG00000115138; HGNC ID: 9201
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space9620771
GO:0005737ISS-cytoplasm-
GO:0030141ISS-secretory granule-
GO:0034774TAS-secretory granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0001664IDA-G-protein coupled receptor binding19452503
GO:0005102IMP-receptor binding9620771
GO:0005179IMP-hormone activity9620771
GO:0005179ISS-hormone activity-
GO:0031781IPI-type 3 melanocortin receptor binding19743876
GO:0031782IPI-type 4 melanocortin receptor binding19743876
GO:0070996IDA-type 1 melanocortin receptor binding18292087
GO:0070996IPI-type 1 melanocortin receptor binding19743876
GO ID Evidence Qualifier GO_term References
GO:0006091IMP-generation of precursor metabolites and energy9620771
GO:0007165IMP-signal transduction9620771
GO:0007218IEA-neuropeptide signaling pathway-
GO:0007267IMP-cell-cell signaling9620771
GO:0008217ISS-regulation of blood pressure-
GO:0016486TAS-peptide hormone processing-
GO:0032098IMP-regulation of appetite9620771
GO:0032720IDA-negative regulation of tumor necrosis factor production10233018
GO:0033059IMP-cellular pigmentation9620771
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter18292087
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
POMCHLA-DRB31093707477400 Co-crystal Structure
POMCHLA-DRB31114397477400 Co-crystal Structure
POMCMC1R1103279058374 Reconstituted Complex
POMCMC1R1114399058374 Reconstituted Complex
POMCMC3R1103299058374 Reconstituted Complex
POMCMC3R1114399058374 Reconstituted Complex
POMCMC4R1103309058374 11101306 Reconstituted Complex
POMCMC4R1114399058374 11101306 Reconstituted Complex
POMCMC5R1103319058374 Reconstituted Complex
POMCMC5R1114399058374 Reconstituted Complex
VTNPOMC1132872475499 Reconstituted Complex
VTNPOMC1114392475499 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
POMCrs1042571, rs2071345, rs28930368 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:97742
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030513-2'