AutismKB 2.0

Annotation Details for RNF216


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Basic Information Top
Gene Symbol:RNF216 ( TRIAD3,U7I1,UBCE7IP1,ZIN )
Gene Full Name: ring finger protein 216
Band: 7p22.1
Quick LinksEntrez ID:54476; OMIM: 609948; Uniprot ID:RN216_HUMAN; ENSEMBL ID: ENSG00000011275; HGNC ID: 21698
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus-
GO:0005654IDA-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding19893624
GO:0046872IEA-metal ion binding-
GO:0061630EXP-ubiquitin protein ligase activity19893624
GO ID Evidence Qualifier GO_term References
GO:0006915IEA-apoptotic process-
GO:0016032IEA-viral process-
GO:0032480TAS-negative regulation of type I interferon production-
GO:0032648IDA-regulation of interferon-beta production19893624
GO:0043161IDA-proteasome-mediated ubiquitin-dependent protein catabolic process19893624
GO:0050691IDA-regulation of defense response to virus by host19893624
GO:0070936IDA-protein K48-linked ubiquitination19893624
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RNF216TLR311295315107846 Two-hybrid
RNF216TLR311998115107846 Two-hybrid
RNF216TLR411295415107846 Two-hybrid
RNF216TLR411998115107846 Two-hybrid
RNF216TLR511295515107846 Two-hybrid
RNF216TLR511998115107846 Two-hybrid
RNF216UBE2H11998115107846 Affinity Capture-Western
RNF216UBE2H11317615107846 Affinity Capture-Western
RNF216UBE2L311318015107846 Affinity Capture-Western
RNF216UBE2L311998115107846 Affinity Capture-Western
RNF216RIPK111427411854271 16968706 Affinity Capture-Western; Two-hybrid
RNF216RIPK111998111854271 16968706 Affinity Capture-Western; Two-hybrid
RNF216UBE2L611467215107846 Affinity Capture-Western
RNF216UBE2L611998115107846 Affinity Capture-Western
RNF216UBE2C11624915107846 Affinity Capture-Western
RNF216UBE2C11998115107846 Affinity Capture-Western
RNF216TLR911990215107846 Two-hybrid
RNF216TLR911998115107846 Two-hybrid
RNF216RNF21611998116169070 Two-hybrid
TIRAPRNF21612532516968706 Affinity Capture-Western
TIRAPRNF21611998116968706 Affinity Capture-Western
TICAM1RNF21612711416968706 Affinity Capture-Western
TICAM1RNF21611998116968706 Affinity Capture-Western
No data
Gene Symbol Interactant Interaction ID References Description
RNF216RNF2161555016169070 -
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1344349
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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