Annotation Details for ATR
Basic Information Top
| Gene Symbol: | ATR ( FRP1,MEC1,SCKL,SCKL1 ) |
|---|---|
| Gene Full Name: | ataxia telangiectasia and Rad3 related |
| Band: | 3q23 |
| Quick Links | Entrez ID:545; OMIM: 601215; Uniprot ID:ATR_HUMAN; ENSEMBL ID: ENSG00000175054; HGNC ID: 882 |
| Relate to Another Database: | SFARIGene; denovo-db |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0000784 | IC | colocalizes_with | nuclear chromosome, telomeric region | 26586433 |
| GO:0005654 | IDA | - | nucleoplasm | - |
| GO:0005654 | TAS | - | nucleoplasm | - |
| GO:0005694 | ISS | - | chromosome | - |
| GO:0005794 | IDA | - | Golgi apparatus | - |
| GO:0016605 | IDA | - | PML body | 12814551 |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0003677 | IEA | - | DNA binding | - |
| GO:0004672 | IDA | - | protein kinase activity | 14657349 |
| GO:0004674 | IDA | - | protein serine/threonine kinase activity | 9733515 |
| GO:0004674 | TAS | - | protein serine/threonine kinase activity | - |
| GO:0005515 | IPI | - | protein binding | 14657349 |
| GO:0005524 | IEA | - | ATP binding | - |
| GO:0032405 | IDA | - | MutLalpha complex binding | 16713580 |
| GO:0032407 | IDA | - | MutSalpha complex binding | 16713580 |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0000077 | IDA | - | DNA damage checkpoint | 14657349 |
| GO:0006260 | TAS | - | DNA replication | - |
| GO:0006281 | TAS | - | DNA repair | 8610130 |
| GO:0006974 | IDA | - | cellular response to DNA damage stimulus | 27723717 |
| GO:0006974 | TAS | - | cellular response to DNA damage stimulus | 15538388 |
| GO:0007049 | TAS | - | cell cycle | 9590286 |
| GO:0007275 | TAS | - | multicellular organism development | 9590286 |
| GO:0008156 | IMP | - | negative regulation of DNA replication | 14657349 |
| GO:0018105 | IDA | - | peptidyl-serine phosphorylation | 9733515 |
| GO:0032212 | ISS | - | positive regulation of telomere maintenance via telomerase | - |
| GO:0034644 | IMP | - | cellular response to UV | 9925639 |
| GO:0036297 | TAS | - | interstrand cross-link repair | - |
| GO:0042493 | IEA | - | response to drug | - |
| GO:0043517 | IMP | - | positive regulation of DNA damage response, signal transduction by p53 class mediator | 9925639 |
| GO:0046777 | IDA | - | protein autophosphorylation | 9733515 |
| GO:0070198 | IMP | - | protein localization to chromosome, telomeric region | 21829167 |
| GO:0071480 | IDA | - | cellular response to gamma radiation | 9925639 |
| GO:0090399 | IMP | - | replicative senescence | 15149599 |
| GO:0097694 | IMP | - | establishment of RNA localization to telomere | 26586433 |
| GO:0097695 | IC | - | establishment of macromolecular complex localization to telomere | 26586433 |
| GO:1900034 | TAS | - | regulation of cellular response to heat | - |
| GO:1901796 | TAS | - | regulation of signal transduction by p53 class mediator | - |
| GO:1904884 | IMP | - | positive regulation of telomerase catalytic core complex assembly | 26586433 |
| Gene Symbol | Interactant | Interaction ID | References | Description |
|---|---|---|---|---|
| ATR | ABL1 | 107027 | 10608806 | Protein-peptide |
| ATR | ABL1 | 106543 | 10608806 | Protein-peptide |
| ATR | AP2A2 | 106670 | 10608806 | Protein-peptide |
| ATR | AP2A2 | 107027 | 10608806 | Protein-peptide |
| ATR | AP1B1 | 107027 | 10608806 | Protein-peptide |
| ATR | AP1B1 | 106671 | 10608806 | Protein-peptide |
| ATR | ATM | 107027 | 10608806 17124492 | Biochemical Activity; Protein-peptide |
| ATR | ATM | 106962 | 10608806 17124492 | Biochemical Activity; Protein-peptide |
| CHD4 | ATR | 107027 | 10545197 | Affinity Capture-MS; Affinity Capture-Western |
| CHD4 | ATR | 107533 | 10545197 | Affinity Capture-MS; Affinity Capture-Western |
| HDAC1 | ATR | 107027 | 10545197 | Affinity Capture-Western |
| HDAC1 | ATR | 109315 | 10545197 | Affinity Capture-Western |
| MTA1 | ATR | 114562 | 10545197 | Affinity Capture-Western |
| MTA1 | ATR | 107027 | 10545197 | Affinity Capture-Western |
| MTA2 | ATR | 114652 | 10545197 | Affinity Capture-Western |
| MTA2 | ATR | 107027 | 10545197 | Affinity Capture-Western |
| HDAC2 | ATR | 107027 | 10545197 | Affinity Capture-Western; Co-purification |
| HDAC2 | ATR | 109316 | 10545197 | Affinity Capture-Western; Co-purification |
| RAD17 | ATR | 111821 | 10608806 11418864 | Affinity Capture-Western; Biochemical Activity; Protein-peptide |
| RAD17 | ATR | 107027 | 10608806 11418864 | Affinity Capture-Western; Biochemical Activity; Protein-peptide |
| RPA1 | ATR | 107027 | 10608806 18162465 | Affinity Capture-Western; Protein-peptide |
| RPA1 | ATR | 112037 | 10608806 18162465 | Affinity Capture-Western; Protein-peptide |
| BRCA1 | ATR | 107027 | 10608806 11016625 11114888 11278964 17478428 | Affinity Capture-Western; Protein-peptide; Reconstituted Complex |
| BRCA1 | ATR | 107140 | 10608806 11016625 11114888 11278964 17478428 | Affinity Capture-Western; Protein-peptide; Reconstituted Complex |
| CHEK1 | ATR | 107027 | 10608806 | Protein-peptide |
| CHEK1 | ATR | 107536 | 10608806 | Protein-peptide |
| E4F1 | ATR | 108209 | 10608806 | Protein-peptide |
| E4F1 | ATR | 107027 | 10608806 | Protein-peptide |
| LIG4 | ATR | 107027 | 10608806 | Protein-peptide |
| LIG4 | ATR | 110169 | 10608806 | Protein-peptide |
| MRE11A | ATR | 107027 | 10608806 | Protein-peptide |
| MRE11A | ATR | 110501 | 10608806 | Protein-peptide |
| NBN | ATR | 110763 | 10608806 | Protein-peptide |
| NBN | ATR | 107027 | 10608806 | Protein-peptide |
| PA2G4 | ATR | 111075 | 10608806 | Protein-peptide |
| PA2G4 | ATR | 107027 | 10608806 | Protein-peptide |
| PIK3CA | ATR | 107027 | 10608806 | Protein-peptide |
| PIK3CA | ATR | 111308 | 10608806 | Protein-peptide |
| POLD1 | ATR | 107027 | 10608806 | Protein-peptide |
| POLD1 | ATR | 111420 | 10608806 | Protein-peptide |
| ATR | ATR | 107027 | 10608806 | Protein-peptide |
| PPP2R2A | ATR | 107027 | 10608806 | Protein-peptide |
| PPP2R2A | ATR | 111512 | 10608806 | Protein-peptide |
| PTS | ATR | 107027 | 10608806 | Protein-peptide |
| PTS | ATR | 111769 | 10608806 | Protein-peptide |
| BRCA2 | ATR | 107027 | 10608806 | Protein-peptide |
| BRCA2 | ATR | 107142 | 10608806 | Protein-peptide |
| WRN | ATR | 113323 | 10608806 | Protein-peptide |
| WRN | ATR | 107027 | 10608806 | Protein-peptide |
| ARHGEF1 | ATR | 114585 | 10608806 | Protein-peptide |
| ARHGEF1 | ATR | 107027 | 10608806 | Protein-peptide |
| TP53 | ATR | 113010 | 10608806 15159397 | Protein-peptide; Reconstituted Complex |
| TP53 | ATR | 107027 | 10608806 15159397 | Protein-peptide; Reconstituted Complex |
| ATRIP | ATR | 313463 | 11721054 14657349 15210935 15451423 18162465 18283122 18344416 19097996 21285353 | Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity |
| ATRIP | ATR | 107027 | 11721054 14657349 15210935 15451423 18162465 18283122 18344416 19097996 21285353 | Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity |
| CLSPN | ATR | 122015 | 12766152 | Affinity Capture-Western |
| CLSPN | ATR | 107027 | 12766152 | Affinity Capture-Western |
| MSH2 | ATR | 110573 | 14657349 21285353 | Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex |
| MSH2 | ATR | 107027 | 14657349 21285353 | Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex |
| BLM | ATR | 107027 | 14729972 | Affinity Capture-Western; Biochemical Activity |
| BLM | ATR | 107110 | 14729972 | Affinity Capture-Western; Biochemical Activity |
| MCM7 | ATR | 107027 | 15210935 | Affinity Capture-Western |
| MCM7 | ATR | 110344 | 15210935 | Affinity Capture-Western |
| MCM2 | ATR | 107027 | 15210935 | Biochemical Activity |
| MCM2 | ATR | 110339 | 15210935 | Biochemical Activity |
| SMC1A | ATR | 113871 | 15640246 | Affinity Capture-Western |
| SMC1A | ATR | 107027 | 15640246 | Affinity Capture-Western |
| RHEB | ATR | 107027 | 15854902 | Affinity Capture-Western; Reconstituted Complex |
| RHEB | ATR | 111941 | 15854902 | Affinity Capture-Western; Reconstituted Complex |
| UPF1 | ATR | 107027 | 16488880 | Biochemical Activity |
| UPF1 | ATR | 111908 | 16488880 | Biochemical Activity |
| MCPH1 | ATR | 122776 | 16872911 | Co-localization |
| MCPH1 | ATR | 107027 | 16872911 | Co-localization |
| CHEK2 | ATR | 116369 | 17035231 | Biochemical Activity |
| CHEK2 | ATR | 107027 | 17035231 | Biochemical Activity |
| RPA2 | ATR | 112038 | 17035231 | Biochemical Activity |
| RPA2 | ATR | 107027 | 17035231 | Biochemical Activity |
| PMS1 | ATR | 107027 | 17148452 | Affinity Capture-Western |
| PMS1 | ATR | 111391 | 17148452 | Affinity Capture-Western |
| HUS1 | ATR | 107027 | 18162465 | Affinity Capture-Western |
| HUS1 | ATR | 109596 | 18162465 | Affinity Capture-Western |
| RAD1 | ATR | 107027 | 18162465 | Affinity Capture-Western |
| RAD1 | ATR | 111771 | 18162465 | Affinity Capture-Western |
| RAD9A | ATR | 107027 | 18162465 | Affinity Capture-Western |
| RAD9A | ATR | 111820 | 18162465 | Affinity Capture-Western |
| CEP164 | ATR | 107027 | 18283122 | Affinity Capture-Western; Biochemical Activity; Reconstituted Complex |
| CEP164 | ATR | 116561 | 18283122 | Affinity Capture-Western; Biochemical Activity; Reconstituted Complex |
| C19orf40 | ATR | 124833 | 18995830 | Co-fractionation |
| C19orf40 | ATR | 107027 | 18995830 | Co-fractionation |
| TOPBP1 | ATR | 116256 | 19097996 | Affinity Capture-Western |
| TOPBP1 | ATR | 107027 | 19097996 | Affinity Capture-Western |
| CLK2 | ATR | 107027 | 19097996 | Affinity Capture-Western |
| CLK2 | ATR | 107607 | 19097996 | Affinity Capture-Western |
| FANCA | ATR | 107027 | 19109555 | Biochemical Activity |
| FANCA | ATR | 108472 | 19109555 | Biochemical Activity |
| H2AFX | ATR | 107027 | 19805520 | Co-localization |
| H2AFX | ATR | 109268 | 19805520 | Co-localization |
| XPC | ATR | 113345 | 19805520 | Co-localization |
| XPC | ATR | 107027 | 19805520 | Co-localization |
| MSH6 | ATR | 109211 | 20029092 | Affinity Capture-Western |
| MSH6 | ATR | 107027 | 20029092 | Affinity Capture-Western |
| CDC6 | ATR | 107027 | 20048340 | Affinity Capture-Western; Reconstituted Complex |
| CDC6 | ATR | 107426 | 20048340 | Affinity Capture-Western; Reconstituted Complex |
| TELO2 | ATR | 107027 | 20427287 20801936 | Affinity Capture-MS; Affinity Capture-Western |
| TELO2 | ATR | 115223 | 20427287 20801936 | Affinity Capture-MS; Affinity Capture-Western |
| TTI1 | ATR | 115030 | 20427287 | Affinity Capture-Western |
| TTI1 | ATR | 107027 | 20427287 | Affinity Capture-Western |
| POLN | ATR | 131695 | 21242293 | Biochemical Activity |
| POLN | ATR | 107027 | 21242293 | Biochemical Activity |
| No data |
| No data |



AlzGene, PDGene and SZGene