Annotation Details for POU4F2

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	POU4F2 ( BRN3.2,BRN3B,Brn-3b )
Gene Full Name:	POU class 4 homeobox 2
Band:	4q31.22
Quick Links	Entrez ID:5458; OMIM: 113725; Uniprot ID:PO4F2_HUMAN; ENSEMBL ID: ENSG00000151615; HGNC ID: 9219
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:6 results
Molecular Function:7 results
Biological Process:28 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	IC	-	nucleus	21241485
GO:0005634	ISS	-	nucleus	-
GO:0005654	TAS	-	nucleoplasm	-
GO:0005737	ISS	-	cytoplasm	-
GO:0005886	IEA	-	plasma membrane	-
GO:0016607	IDA	-	nuclear speck	19266028

GO ID	Evidence	Qualifier	GO_term	References
GO:0000978	IDA	-	RNA polymerase II core promoter proximal region sequence-specific DNA binding	17637757
GO:0000981	IDA	-	RNA polymerase II transcription factor activity, sequence-specific DNA binding	23805044
GO:0001077	IDA	-	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	17637757
GO:0001078	ISS	-	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	-
GO:0003713	ISS	-	transcription coactivator activity	-
GO:0003714	ISS	-	transcription corepressor activity	-
GO:1990841	ISS	-	promoter-specific chromatin binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000122	ISS	-	negative regulation of transcription from RNA polymerase II promoter	-
GO:0000165	IDA	-	MAPK cascade	21241485
GO:0006366	IEA	-	transcription from RNA polymerase II promoter	-
GO:0007283	IEA	-	spermatogenesis	-
GO:0007411	ISS	-	axon guidance	-
GO:0007605	IEA	-	sensory perception of sound	-
GO:0030182	ISS	-	neuron differentiation	-
GO:0030520	IDA	-	intracellular estrogen receptor signaling pathway	21241485
GO:0031290	IEA	-	retinal ganglion cell axon guidance	-
GO:0043068	ISS	-	positive regulation of programmed cell death	-
GO:0043433	ISS	-	negative regulation of sequence-specific DNA binding transcription factor activity	-
GO:0045596	ISS	-	negative regulation of cell differentiation	-
GO:0045597	ISS	-	positive regulation of cell differentiation	-
GO:0045672	ISS	-	positive regulation of osteoclast differentiation	-
GO:0045773	ISS	-	positive regulation of axon extension	-
GO:0045944	IDA	-	positive regulation of transcription from RNA polymerase II promoter	17637757
GO:0048675	IEA	-	axon extension	-
GO:0050885	IEA	-	neuromuscular process controlling balance	-
GO:0051090	ISS	-	regulation of sequence-specific DNA binding transcription factor activity	-
GO:0060041	ISS	-	retina development in camera-type eye	-
GO:0071345	ISS	-	cellular response to cytokine stimulus	-
GO:0071392	ISS	-	cellular response to estradiol stimulus	-
GO:0072332	ISS	-	intrinsic apoptotic signaling pathway by p53 class mediator	-
GO:0090259	ISS	-	regulation of retinal ganglion cell axon guidance	-
GO:1901796	TAS	-	regulation of signal transduction by p53 class mediator	-
GO:1902870	ISS	-	negative regulation of amacrine cell differentiation	-
GO:1990791	ISS	-	dorsal root ganglion development	-
GO:2000679	ISS	-	positive regulation of transcription regulatory region DNA binding	-

Protein-Protein Interaction

BioGRID:2 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
POU4F2	ESR1	108403	9448000	Reconstituted Complex; Two-hybrid
POU4F2	ESR1	111454	9448000	Reconstituted Complex; Two-hybrid

AlzGene, PDGene and SZGene

Animal Model

Mouse:1 results
Fruit Fly:1 results

MGI ID: MGI:102524
Data Attributes: HomoloGene calculated