AutismKB 2.0

Annotation Details for ATRX


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Basic Information Top
Gene Symbol:ATRX ( ATR2,MGC2094,MRXHF1,RAD54,RAD54L,SFM1,SHS,XH2,XNP,ZNF-HX )
Gene Full Name: alpha thalassemia/mental retardation syndrome X-linked
Band: Xq21.1
Quick LinksEntrez ID:546; OMIM: 300032; Uniprot ID:ATRX_HUMAN; ENSEMBL ID: ENSG00000085224; HGNC ID: 886
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000780IEA-condensed nuclear chromosome, centromeric region-
GO:0000784ISS-nuclear chromosome, telomeric region-
GO:0000784ISScolocalizes_withnuclear chromosome, telomeric region-
GO:0005634TAS-nucleus7874112
GO:0005654IDA-nucleoplasm-
GO:0005720TAS-nuclear heterochromatin10570185
GO:0005721ISS-pericentric heterochromatin-
GO:0016604IDA-nuclear body-
GO:0016605ISS-PML body-
GO:0031618IEA-nuclear pericentric heterochromatin-
GO:0031933ISS-telomeric heterochromatin-
GO:0070603IDA-SWI/SNF superfamily-type complex12953102
GO:1990707IDA-nuclear subtelomeric heterochromatin26055325
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0003678TAS-DNA helicase activity7697714
GO:0003682IDA-chromatin binding27029610
GO:0004386TAS-helicase activity7874112
GO:0005515IPI-protein binding10699177
GO:0005524IEA-ATP binding-
GO:0015616IDA-DNA translocase activity12953102
GO:0035064IDA-methylated histone binding21421568
GO:0042393IDA-histone binding20211137
GO:0046872IEA-metal ion binding-
GO:0070087IPI-chromo shadow domain binding15882967
GO ID Evidence Qualifier GO_term References
GO:0000212IEA-meiotic spindle organization-
GO:0006281IEA-DNA repair-
GO:0006306TAS-DNA methylation10742099
GO:0006310TAS-DNA recombination7697714
GO:0006334IDA-nucleosome assembly20651253
GO:0006336IMP-DNA replication-independent nucleosome assembly22391447
GO:0006338IDA-chromatin remodeling20651253
GO:0006351IEA-transcription, DNA-templated-
GO:0006355TAS-regulation of transcription, DNA-templated7697714
GO:0007283IEA-spermatogenesis-
GO:0010571ISS-positive regulation of nuclear cell cycle DNA replication-
GO:0016569IEA-covalent chromatin modification-
GO:0030330ISS-DNA damage response, signal transduction by p53 class mediator-
GO:0030900IEA-forebrain development-
GO:0031297ISS-replication fork processing-
GO:0032206ISS-positive regulation of telomere maintenance-
GO:0032508IEA-DNA duplex unwinding-
GO:0035128IEA-post-embryonic forelimb morphogenesis-
GO:0035264IEA-multicellular organism growth-
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter22391447
GO:0060009IEA-Sertoli cell development-
GO:0070192IEA-chromosome organization involved in meiotic cell cycle-
GO:0070198ISS-protein localization to chromosome, telomeric region-
GO:0072520IEA-seminiferous tubule development-
GO:0072711ISS-cellular response to hydroxyurea-
GO:1900112IMP-regulation of histone H3-K9 trimethylation27029610
GO:1901581ISS-negative regulation of telomeric RNA transcription from RNA pol II promoter-
GO:1901582IMP-positive regulation of telomeric RNA transcription from RNA pol II promoter26055325
GO:1904908IMP-negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric26373281
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EZH2ATRX1070289499421 Reconstituted Complex; Two-hybrid
EZH2ATRX1084469499421 Reconstituted Complex; Two-hybrid
CBX5ATRX11703010699177 15882967 20110566 Affinity Capture-Western; Co-localization; Protein-peptide
CBX5ATRX10702810699177 15882967 20110566 Affinity Capture-Western; Co-localization; Protein-peptide
RAD51ATRX11182510851248 12205100 15466868 Reconstituted Complex; Two-hybrid
RAD51ATRX10702810851248 12205100 15466868 Reconstituted Complex; Two-hybrid
DAXXATRX10798512953102 14990586 15252119 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex
DAXXATRX10702812953102 14990586 15252119 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex
HDAC4ATRX11510615964851 Two-hybrid
HDAC4ATRX10702815964851 Two-hybrid
LUC7L2ATRX11964616169070 Two-hybrid
LUC7L2ATRX10702816169070 Two-hybrid
FAM190BATRX11996816169070 Two-hybrid
FAM190BATRX10702816169070 Two-hybrid
KIAA1377ATRX12161716169070 Two-hybrid
KIAA1377ATRX10702816169070 Two-hybrid
PTNATRX11173116169070 Two-hybrid
PTNATRX10702816169070 Two-hybrid
PTPN4ATRX11174116169070 Two-hybrid
PTPN4ATRX10702816169070 Two-hybrid
EIF4A2ATRX10702817353931 Affinity Capture-MS
EIF4A2ATRX10829017353931 Affinity Capture-MS
SUMO2ATRX11249719394292 Affinity Capture-MS
SUMO2ATRX10702819394292 Affinity Capture-MS
H3F3AATRX10702820110566 Affinity Capture-Western
H3F3AATRX10927220110566 Affinity Capture-Western
H3F3BATRX10927320110566 Affinity Capture-Western
H3F3BATRX10702820110566 Affinity Capture-Western
SMC1AATRX11387120159591 Affinity Capture-Western
SMC1AATRX10702820159591 Affinity Capture-Western
HIST1H3AATRX11394621421568 Reconstituted Complex
HIST1H3AATRX10702821421568 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030912-11'