AutismKB 2.0

Annotation Details for PPARA


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Basic Information Top
Gene Symbol:PPARA ( MGC2237,MGC2452,NR1C1,PPAR,PPARalpha,hPPAR )
Gene Full Name: peroxisome proliferator-activated receptor alpha
Band: 22q13.31
Quick LinksEntrez ID:5465; OMIM: 170998; Uniprot ID:PPARA_HUMAN; ENSEMBL ID: ENSG00000186951; HGNC ID: 9232
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus24639097
GO:0005634TAS-nucleus16271724
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO ID Evidence Qualifier GO_term References
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding9748239
GO:0001077IDA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding9748239
GO:0001078IDA-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding9748239
GO:0001103IPI-RNA polymerase II repressing transcription factor binding19955185
GO:0001190IEA-transcriptional activator activity, RNA polymerase II transcription factor binding-
GO:0001223IEA-transcription coactivator binding-
GO:0003677TAS-DNA binding10860941
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding19955185
GO:0003700ISS-transcription factor activity, sequence-specific DNA binding-
GO:0003707IDA-steroid hormone receptor activity19955185
GO:0004879IDA-RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding12955147
GO:0005515IPI-protein binding9653119
GO:0008134IPI-transcription factor binding26504087
GO:0008144IDA-drug binding9113987
GO:0008270IEA-zinc ion binding-
GO:0008289IDA-lipid binding12955147
GO:0019902IEA-phosphatase binding-
GO:0019904IEA-protein domain specific binding-
GO:0031624IPI-ubiquitin conjugating enzyme binding19955185
GO:0032403IEA-protein complex binding-
GO:0043565ISS-sequence-specific DNA binding-
GO:0051525IEA-NFAT protein binding-
GO:0097371IEA-MDM2/MDM4 family protein binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter9748239
GO:0001666IEA-response to hypoxia-
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0006629TAS-lipid metabolic process7684926
GO:0006631IEA-fatty acid metabolic process-
GO:0007507IEA-heart development-
GO:0008544IEA-epidermis development-
GO:0010745IC-negative regulation of macrophage derived foam cell differentiation12700342
GO:0010745IDA-negative regulation of macrophage derived foam cell differentiation19114110
GO:0010871IDA-negative regulation of receptor biosynthetic process12700342
GO:0010887IDA-negative regulation of cholesterol storage19114110
GO:0010891IDA-negative regulation of sequestering of triglyceride12700342
GO:0015908TAS-fatty acid transport16271724
GO:0019216TAS-regulation of lipid metabolic process-
GO:0030522IEA-intracellular receptor signaling pathway-
GO:0032000TAS-positive regulation of fatty acid beta-oxidation16271724
GO:0032091IEA-negative regulation of protein binding-
GO:0032099ISS-negative regulation of appetite-
GO:0032868IEA-response to insulin-
GO:0032922ISS-circadian regulation of gene expression-
GO:0035095IEA-behavioral response to nicotine-
GO:0042060IEA-wound healing-
GO:0042157IEA-lipoprotein metabolic process-
GO:0042752ISS-regulation of circadian rhythm-
GO:0043401IEA-steroid hormone mediated signaling pathway-
GO:0045722IEA-positive regulation of gluconeogenesis-
GO:0045776IEA-negative regulation of blood pressure-
GO:0045820IC-negative regulation of glycolytic process19955185
GO:0045893IDA-positive regulation of transcription, DNA-templated12955147
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter9748239
GO:0046321ISS-positive regulation of fatty acid oxidation-
GO:0050728IDA-negative regulation of inflammatory response21636785
GO:0070166IEA-enamel mineralization-
GO:0072363IDA-regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter19955185
GO:0072366IDA-regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter19955185
GO:0072369IDA-regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter19955185
GO:1901215IEA-negative regulation of neuron death-
GO:1902894IDA-negative regulation of pri-miRNA transcription from RNA polymerase II promoter21636785
GO:1903038IDA-negative regulation of leukocyte cell-cell adhesion21636785
GO:2000678IEA-negative regulation of transcription regulatory region DNA binding-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PPARAEP3001083479407140 10336495 Reconstituted Complex; Two-hybrid
PPARAEP3001114619407140 10336495 Reconstituted Complex; Two-hybrid
PPARAFABP110846611226238 Two-hybrid
PPARAFABP111146111226238 Two-hybrid
PPARAHSP90AA111146112482853 Affinity Capture-Western; Reconstituted Complex
PPARAHSP90AA110955212482853 Affinity Capture-Western; Reconstituted Complex
PPARAPOU1F111144511891224 Reconstituted Complex
PPARAPOU1F111146111891224 Reconstituted Complex
NR1H3PPARA1153738621574 Reconstituted Complex
NR1H3PPARA1114618621574 Reconstituted Complex
NCOA1PPARA1142009407140 9626662 Reconstituted Complex; Two-hybrid
NCOA1PPARA1114619407140 9626662 Reconstituted Complex; Two-hybrid
NRIP1PPARA1138439626662 Reconstituted Complex
NRIP1PPARA1114619626662 Reconstituted Complex
AKAP13PPARA1163839627117 Reconstituted Complex
AKAP13PPARA1114619627117 Reconstituted Complex
MED24PPARA1151969653119 Reconstituted Complex
MED24PPARA1114619653119 Reconstituted Complex
MECRPPARA1192919795230 Reconstituted Complex
MECRPPARA1114619795230 Reconstituted Complex
RXRAPPARA11146110195690 Reconstituted Complex
RXRAPPARA11216810195690 Reconstituted Complex
NCOR1PPARA11497310336495 15870285 18292238 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOR1PPARA11146110336495 15870285 18292238 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RELAPPARA11146110542237 Reconstituted Complex
RELAPPARA11190210542237 Reconstituted Complex
PPARGC1APPARA11609710669761 Reconstituted Complex
PPARGC1APPARA11146110669761 Reconstituted Complex
NRBF2PPARA11900910786636 Two-hybrid
NRBF2PPARA11146110786636 Two-hybrid
GADD45GPPARA11611710872826 Reconstituted Complex
GADD45GPPARA11146110872826 Reconstituted Complex
DAP3PPARA11358710903152 Reconstituted Complex
DAP3PPARA11146110903152 Reconstituted Complex
PPARGC1BPPARA12636111733490 Reconstituted Complex
PPARGC1BPPARA11146111733490 Reconstituted Complex
NCOR2PPARA11497411845213 Co-crystal Structure
NCOR2PPARA11146111845213 Co-crystal Structure
SRCPPARA11259212163133 FRET
SRCPPARA11146112163133 FRET
PRIC285PPARA12452812189208 Reconstituted Complex
PRIC285PPARA11146112189208 Reconstituted Complex
AIPPPARA11451112482853 Affinity Capture-Western; Reconstituted Complex
AIPPPARA11146112482853 Affinity Capture-Western; Reconstituted Complex
RXRGPPARA11217016169070 Two-hybrid
RXRGPPARA11146116169070 Two-hybrid
STAC3PPARA12889916189514 Two-hybrid
STAC3PPARA11146116189514 Two-hybrid
TRA@PPARA11281519782026 Co-localization
TRA@PPARA11146119782026 Co-localization
Gene Symbol Interactant Interaction ID References Description
CEP350PPARA21434715615782 CAP350 interacts with PPAR-alpha.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
PPARArs1800206, rs4253778 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
PPARArs1800234 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:104740
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041210-169'