Gene Symbol:	PPARD ( FAAR,MGC3931,NR1C2,NUC1,NUCI,NUCII,PPARB )
Gene Full Name:	peroxisome proliferator-activated receptor delta
Band:	6p21.31
Quick Links	Entrez ID:5467; OMIM: 600409; Uniprot ID:PPARD_HUMAN; ENSEMBL ID: ENSG00000112033; HGNC ID: 9235
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0000790	ISS	-	nuclear chromatin	-
GO:0005634	NAS	-	nucleus	11551955
GO:0005654	TAS	-	nucleoplasm	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001227	ISS	-	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	-
GO:0003677	ISS	-	DNA binding	-
GO:0003700	IDA	-	transcription factor activity, sequence-specific DNA binding	12955147
GO:0003700	NAS	-	transcription factor activity, sequence-specific DNA binding	11551955
GO:0003707	IEA	-	steroid hormone receptor activity	-
GO:0003713	IEA	-	transcription coactivator activity	-
GO:0004879	IDA	-	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	12955147
GO:0005515	IPI	-	protein binding	23455924
GO:0008134	IPI	-	transcription factor binding	26504087
GO:0008144	IDA	-	drug binding	9113987
GO:0008270	IEA	-	zinc ion binding	-
GO:0008289	IDA	-	lipid binding	12955147
GO:0043565	IEA	-	sequence-specific DNA binding	-
GO:0046982	IEA	-	protein heterodimerization activity	-
GO:0051059	IEA	-	NF-kappaB binding	-
GO:0070539	IDA	-	linoleic acid binding	10198642

GO ID	Evidence	Qualifier	GO_term	References
GO:0000122	ISS	-	negative regulation of transcription from RNA polymerase II promoter	-
GO:0006006	NAS	-	glucose metabolic process	15793256
GO:0006029	IEA	-	proteoglycan metabolic process	-
GO:0006091	TAS	-	generation of precursor metabolites and energy	1333051
GO:0006357	TAS	-	regulation of transcription from RNA polymerase II promoter	1333051
GO:0006367	TAS	-	transcription initiation from RNA polymerase II promoter	-
GO:0006629	ISS	-	lipid metabolic process	-
GO:0006635	ISS	-	fatty acid beta-oxidation	-
GO:0006635	TAS	-	fatty acid beta-oxidation	15192438
GO:0006776	IEA	-	vitamin A metabolic process	-
GO:0006915	IMP	-	apoptotic process	12909723
GO:0007507	IEA	-	heart development	-
GO:0007566	TAS	-	embryo implantation	11551955
GO:0008203	TAS	-	cholesterol metabolic process	15192438
GO:0008283	ISS	-	cell proliferation	-
GO:0008283	TAS	-	cell proliferation	11847022
GO:0008366	ISS	-	axon ensheathment	-
GO:0008654	IEA	-	phospholipid biosynthetic process	-
GO:0009062	TAS	-	fatty acid catabolic process	15192438
GO:0009299	IEA	-	mRNA transcription	-
GO:0009749	IEA	-	response to glucose	-
GO:0014068	IEA	-	positive regulation of phosphatidylinositol 3-kinase signaling	-
GO:0014823	IEA	-	response to activity	-
GO:0014842	IEA	-	regulation of skeletal muscle satellite cell proliferation	-
GO:0014912	IEA	-	negative regulation of smooth muscle cell migration	-
GO:0015758	NAS	-	glucose transport	15793256
GO:0015908	ISS	-	fatty acid transport	-
GO:0030154	IEA	-	cell differentiation	-
GO:0030308	IEA	-	negative regulation of cell growth	-
GO:0030522	IEA	-	intracellular receptor signaling pathway	-
GO:0031589	IEA	-	cell-substrate adhesion	-
GO:0032024	IEA	-	positive regulation of insulin secretion	-
GO:0032966	IEA	-	negative regulation of collagen biosynthetic process	-
GO:0033189	IEA	-	response to vitamin A	-
GO:0042060	IEA	-	wound healing	-
GO:0043066	IEA	-	negative regulation of apoptotic process	-
GO:0043401	IEA	-	steroid hormone mediated signaling pathway	-
GO:0043415	IEA	-	positive regulation of skeletal muscle tissue regeneration	-
GO:0043616	IEA	-	keratinocyte proliferation	-
GO:0045600	NAS	-	positive regulation of fat cell differentiation	10991946
GO:0045662	IEA	-	negative regulation of myoblast differentiation	-
GO:0045684	IEA	-	positive regulation of epidermis development	-
GO:0045892	ISS	-	negative regulation of transcription, DNA-templated	-
GO:0045893	IDA	-	positive regulation of transcription, DNA-templated	12955147
GO:0046697	TAS	-	decidualization	11551955
GO:0048662	IEA	-	negative regulation of smooth muscle cell proliferation	-
GO:0050680	IEA	-	negative regulation of epithelial cell proliferation	-
GO:0050728	IEA	-	negative regulation of inflammatory response	-
GO:0051546	IEA	-	keratinocyte migration	-
GO:0060612	IEA	-	adipose tissue development	-
GO:0071222	IEA	-	cellular response to lipopolysaccharide	-
GO:0071456	IEA	-	cellular response to hypoxia	-
GO:0097190	IMP	-	apoptotic signaling pathway	11551955
GO:0097755	IEA	-	positive regulation of blood vessel diameter	-
GO:1902894	ISS	-	negative regulation of pri-miRNA transcription from RNA polymerase II promoter	-
GO:2000288	IEA	-	positive regulation of myoblast proliferation	-

Gene Symbol	Interactant	Interaction ID	References	Description
PPARD	EP300	108347	16930961	Reconstituted Complex
PPARD	EP300	111463	16930961	Reconstituted Complex
PPARD	HDAC1	109315	11867749 18037904	Affinity Capture-Western; Reconstituted Complex
PPARD	HDAC1	111463	11867749 18037904	Affinity Capture-Western; Reconstituted Complex
PPARD	HDAC2	109316	11867749	Affinity Capture-Western
PPARD	HDAC2	111463	11867749	Affinity Capture-Western
GADD45G	PPARD	111463	10872826	Reconstituted Complex
GADD45G	PPARD	116117	10872826	Reconstituted Complex
SPEN	PPARD	116655	11867749	Affinity Capture-Western
SPEN	PPARD	111463	11867749	Affinity Capture-Western
HDAC3	PPARD	111463	11867749 12943985	Affinity Capture-Western; Reconstituted Complex
HDAC3	PPARD	114368	11867749 12943985	Affinity Capture-Western; Reconstituted Complex
NCOR2	PPARD	114974	11867749	Affinity Capture-Western; Two-hybrid
NCOR2	PPARD	111463	11867749	Affinity Capture-Western; Two-hybrid
NCOR1	PPARD	114973	11867749	Two-hybrid
NCOR1	PPARD	111463	11867749	Two-hybrid
HDAC4	PPARD	115106	12943985	Reconstituted Complex
HDAC4	PPARD	111463	12943985	Reconstituted Complex
NCOA2	PPARD	115761	16930961	Reconstituted Complex
NCOA2	PPARD	111463	16930961	Reconstituted Complex
SRC	PPARD	111463	16930961	Reconstituted Complex
SRC	PPARD	112592	16930961	Reconstituted Complex
PPARD	PPARD	111463	17803688	Affinity Capture-Western
RELA	PPARD	111463	18037904	Affinity Capture-Western
RELA	PPARD	111902	18037904	Affinity Capture-Western

AutismKB 2.0

Annotation Details for PPARD