AutismKB 2.0

Annotation Details for SYTL2


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Basic Information Top
Gene Symbol:SYTL2 ( CHR11SYT,EXO4,FLJ21219,FLJ34802,FLJ42764,FLJ45597,KIAA1597,MGC102768,SGA72M,SLP2,SLP2A )
Gene Full Name: synaptotagmin-like 2
Band: 11q14.1
Quick LinksEntrez ID:54843; OMIM: 612880; Uniprot ID:SYTL2_HUMAN; ENSEMBL ID: ENSG00000137501; HGNC ID: 15585
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm18812475
GO:0005886IDA-plasma membrane17182843
GO:0016020ISS-membrane-
GO:0019897ISS-extrinsic component of plasma membrane-
GO:0042470ISS-melanosome-
GO:0070382IDA-exocytic vesicle18812475
GO ID Evidence Qualifier GO_term References
GO:0001786IMP-phosphatidylserine binding17182843
GO:0005509IBA-calcium ion binding-
GO:0005515IPI-protein binding15231748
GO:0005544IBA-calcium-dependent phospholipid binding-
GO:0005546IMP-phosphatidylinositol-4,5-bisphosphate binding17182843
GO:0017137IEA-Rab GTPase binding-
GO:0019902IDA-phosphatase binding19389623
GO:0019905IBA-syntaxin binding-
GO:0030276IBA-clathrin binding-
GO:0042043ISS-neurexin family protein binding-
GO ID Evidence Qualifier GO_term References
GO:0006886IEA-intracellular protein transport-
GO:0006887IDA-exocytosis18812475
GO:0006904IDA-vesicle docking involved in exocytosis18812475
GO:0006906IBA-vesicle fusion-
GO:0010923IDA-negative regulation of phosphatase activity19389623
GO:0016192ISS-vesicle-mediated transport-
GO:0017158IBANOTregulation of calcium ion-dependent exocytosis-
GO:0048791IBANOTcalcium ion-regulated exocytosis of neurotransmitter-
GO:0070257IEA-positive regulation of mucus secretion-
GO:0072659IEA-protein localization to plasma membrane-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SYTL2HNRNPA112019417643375 Affinity Capture-MS
SYTL2HNRNPA110942017643375 Affinity Capture-MS
SYTL2RAB27A12019411773082 11980908 12590134 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SYTL2RAB27A11181111773082 11980908 12590134 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SYTL2RAB27B12019411980908 Two-hybrid
SYTL2RAB27B11181211980908 Two-hybrid
SYTL2RPAP112019417643375 Affinity Capture-MS
SYTL2RPAP111748717643375 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1933366
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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