AutismKB 2.0

Annotation Details for PPM1A


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Basic Information Top
Gene Symbol:PPM1A ( FLJ42306,MGC9201,PP2C-ALPHA,PP2CA,PP2Calpha )
Gene Full Name: protein phosphatase, Mg2+/Mn2+ dependent, 1A
Band: 14q23.1
Quick LinksEntrez ID:5494; OMIM: 606108; Uniprot ID:PPM1A_HUMAN; ENSEMBL ID: ENSG00000100614; HGNC ID: 9275
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16751101
GO:0005654TAS-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0005829ISS-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane-
GO:0016020ISS-membrane-
GO ID Evidence Qualifier GO_term References
GO:0000287IEA-magnesium ion binding-
GO:0004722IDA-protein serine/threonine phosphatase activity10644691
GO:0004722TAS-protein serine/threonine phosphatase activity-
GO:0004871IMP-signal transducer activity12761501
GO:0005515IPI-protein binding10644691
GO:0030145IEA-manganese ion binding-
GO:0033192IDA-calmodulin-dependent protein phosphatase activity11559703
GO:0070412IPI-R-SMAD binding16751101
GO ID Evidence Qualifier GO_term References
GO:0000122TAS-negative regulation of transcription from RNA polymerase II promoter-
GO:0006470IMP-protein dephosphorylation18930133
GO:0006499ISS-N-terminal protein myristoylation-
GO:0007050TAS-cell cycle arrest-
GO:0010991IDA-negative regulation of SMAD protein complex assembly16751101
GO:0016055IDA-Wnt signaling pathway10644691
GO:0016311IDA-dephosphorylation10644691
GO:0030177IDA-positive regulation of Wnt signaling pathway10644691
GO:0030512IDA-negative regulation of transforming growth factor beta receptor signaling pathway16751101
GO:0030514IEA-negative regulation of BMP signaling pathway-
GO:0035970IDA-peptidyl-threonine dephosphorylation11559703
GO:0042347IMP-negative regulation of NF-kappaB import into nucleus18930133
GO:0043123IMP-positive regulation of I-kappaB kinase/NF-kappaB signaling12761501
GO:0043124IMP-negative regulation of I-kappaB kinase/NF-kappaB signaling18930133
GO:0045893IDA-positive regulation of transcription, DNA-templated10644691
GO:0046827IEA-positive regulation of protein export from nucleus-
GO:0071560IEA-cellular response to transforming growth factor beta stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PPM1AGRM311148914663150 Affinity Capture-Western; Two-hybrid
PPM1AGRM310917014663150 Affinity Capture-Western; Two-hybrid
LXNPPM1A12125217353931 Affinity Capture-MS
LXNPPM1A11148917353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99878
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-991102-14'