AutismKB 2.0

Annotation Details for PPP1CA


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Basic Information Top
Gene Symbol:PPP1CA ( MGC15877,MGC1674,PP-1A,PP1alpha,PPP1A )
Gene Full Name: protein phosphatase 1, catalytic subunit, alpha isozyme
Band: 11q13
Quick LinksEntrez ID:5499; OMIM: 176875; Uniprot ID:PP1A_HUMAN; ENSEMBL ID: ENSG00000172531; HGNC ID: 9281
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000164IEA-protein phosphatase type 1 complex-
GO:0000784IDAcolocalizes_withnuclear chromosome, telomeric region24270157
GO:0005634IDA-nucleus11739654
GO:0005654IDA-nucleoplasm-
GO:0005730IEA-nucleolus-
GO:0005737IDA-cytoplasm11739654
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane-
GO:0005913IDA-cell-cell adherens junction25468996
GO:0042587IEA-glycogen granule-
GO:0043197IEA-dendritic spine-
GO:0043204IEA-perikaryon-
GO:0070062IDA-extracellular exosome20458337
GO:0072357IDA-PTW/PP1 phosphatase complex20516061
GO ID Evidence Qualifier GO_term References
GO:0004721ISS-phosphoprotein phosphatase activity-
GO:0004722IEA-protein serine/threonine phosphatase activity-
GO:0005515IPI-protein binding10807923
GO:0008157IEA-protein phosphatase 1 binding-
GO:0016791ISS-phosphatase activity-
GO:0032403IEA-protein complex binding-
GO:0043021IEA-ribonucleoprotein complex binding-
GO:0046872IEA-metal ion binding-
GO:0098641IDA-cadherin binding involved in cell-cell adhesion25468996
GO ID Evidence Qualifier GO_term References
GO:0005977IEA-glycogen metabolic process-
GO:0005979IEA-regulation of glycogen biosynthetic process-
GO:0005981IEA-regulation of glycogen catabolic process-
GO:0006470IMP-protein dephosphorylation22311981
GO:0006470ISS-protein dephosphorylation-
GO:0007049IEA-cell cycle-
GO:0016311IDA-dephosphorylation22311981
GO:0030324IEA-lung development-
GO:0032091ISS-negative regulation of protein binding-
GO:0032922ISS-circadian regulation of gene expression-
GO:0036496ISS-regulation of translational initiation by eIF2 alpha dephosphorylation-
GO:0042752IMP-regulation of circadian rhythm21712997
GO:0043153ISS-entrainment of circadian clock by photoperiod-
GO:0048754IEA-branching morphogenesis of an epithelial tube-
GO:0051301IEA-cell division-
GO:0060828IC-regulation of canonical Wnt signaling pathway17318175
GO:0098609IEA-cell-cell adhesion-
GO:1904886ISS-beta-catenin destruction complex disassembly-
GO:2001241IEA-positive regulation of extrinsic apoptotic signaling pathway in absence of ligand-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PPP1CAACTA110657315107502 Affinity Capture-Western
PPP1CAACTA111149315107502 Affinity Capture-Western
PPP1CABCL2L110707012115603 Affinity Capture-Western; Reconstituted Complex
PPP1CABCL2L111149312115603 Affinity Capture-Western; Reconstituted Complex
PPP1CABCL2L211149312115603 Affinity Capture-Western; Reconstituted Complex
PPP1CABCL2L210707112115603 Affinity Capture-Western; Reconstituted Complex
PPP1CABRCA110714012438214 17511879 Affinity Capture-Western; Reconstituted Complex
PPP1CABRCA111149312438214 17511879 Affinity Capture-Western; Reconstituted Complex
PPP1CACDC5L11149311101529 Affinity Capture-MS; Co-purification
PPP1CACDC5L10742411101529 Affinity Capture-MS; Co-purification
PPP1CACREB110777520498639 Biochemical Activity
PPP1CACREB111149320498639 Biochemical Activity
PPP1CAGSK3B10918712147701 Affinity Capture-Western
PPP1CAGSK3B11149312147701 Affinity Capture-Western
PPP1CAHCFC110930410637318 Affinity Capture-Western; Reconstituted Complex
PPP1CAHCFC111149310637318 Affinity Capture-Western; Reconstituted Complex
PPP1CAHSPA81095449269769 Affinity Capture-Western
PPP1CAHSPA81114939269769 Affinity Capture-Western
PPP1CAIKBKB10976718362886 Affinity Capture-Western
PPP1CAIKBKB11149318362886 Affinity Capture-Western
PPP1CAKCNQ110998511799244 Affinity Capture-Western; Reconstituted Complex
PPP1CAKCNQ111149311799244 Affinity Capture-Western; Reconstituted Complex
PPP1R9BPPP1CA11149310194355 Affinity Capture-Western; Reconstituted Complex
PPP1R9BPPP1CA12420210194355 Affinity Capture-Western; Reconstituted Complex
AKAP11PPP1CA11638410209101 12147701 Affinity Capture-Western; Reconstituted Complex
AKAP11PPP1CA11149310209101 12147701 Affinity Capture-Western; Reconstituted Complex
RRP1BPPP1CA11670810637318 19710015 Affinity Capture-MS; Reconstituted Complex
RRP1BPPP1CA11149310637318 19710015 Affinity Capture-MS; Reconstituted Complex
NOC2LPPP1CA11149310637318 Reconstituted Complex
NOC2LPPP1CA11758610637318 Reconstituted Complex
PPP1R8PPP1CA11150310637318 12788942 Reconstituted Complex
PPP1R8PPP1CA11149310637318 12788942 Reconstituted Complex
PPP1R10PPP1CA11150610637318 Reconstituted Complex
PPP1R10PPP1CA11149310637318 Reconstituted Complex
RYR2PPP1CA11217410830164 Co-fractionation
RYR2PPP1CA11149310830164 Co-fractionation
PPP1R15APPP1CA11149311564868 12016208 12724406 Affinity Capture-Western; Phenotypic Suppression
PPP1R15APPP1CA11717211564868 12016208 12724406 Affinity Capture-Western; Phenotypic Suppression
SMARCB1PPP1CA11248212016208 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex
SMARCB1PPP1CA11149312016208 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex
EIF2AK2PPP1CA11159612138106 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
EIF2AK2PPP1CA11149312138106 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
LMTK2PPP1CA11149312393858 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
NCOR1PPP1CA11497312410313 Affinity Capture-Western
NCOR1PPP1CA11149312410313 Affinity Capture-Western
EEDPPP1CA11426512788942 Reconstituted Complex
EEDPPP1CA11149312788942 Reconstituted Complex
PHACTR3PPP1CA11149312925532 Affinity Capture-Western; Far Western; Two-hybrid
PHACTR3PPP1CA12548312925532 Affinity Capture-Western; Far Western; Two-hybrid
PHACTR1PPP1CA11149315107502 Affinity Capture-Western; Two-hybrid
PHACTR1PPP1CA12874615107502 Affinity Capture-Western; Two-hybrid
RUVBL2PPP1CA11606717643375 Affinity Capture-MS
RUVBL2PPP1CA11149317643375 Affinity Capture-MS
RPAP3PPP1CA11149317643375 Affinity Capture-MS
RPAP3PPP1CA12278317643375 Affinity Capture-MS
RPAP2PPP1CA11149317643375 Affinity Capture-MS
RPAP2PPP1CA12295917643375 Affinity Capture-MS
CUEDC2PPP1CA11149318362886 Affinity Capture-Western
CUEDC2PPP1CA12247518362886 Affinity Capture-Western
CCDC6PPP1CA11372520498639 Co-localization
CCDC6PPP1CA11149320498639 Co-localization
Gene Symbol Interactant Interaction ID References Description
TGFBR2PPP1CA21794715761153 T-beta-RII interacts with an unspecific isoform of PPP1C. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse PPP1C.
TGFBR1PPP1CA21794615761153 T-beta-RI interacts with an unspecific isoform of PPP1C. This interaction was modeled on a demonstrated interaction between human T-beta-RI and mouse PPP1C.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:103016
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040516-3'