AutismKB 2.0

Annotation Details for PPP2R1A


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Basic Information Top
Gene Symbol:PPP2R1A ( MGC786,PP2A-Aalpha,PP2AAALPHA,PR65A )
Gene Full Name: protein phosphatase 2, regulatory subunit A, alpha
Band: 19q13.41
Quick LinksEntrez ID:5518; OMIM: 605983; Uniprot ID:2AAA_HUMAN; ENSEMBL ID: ENSG00000105568; HGNC ID: 9302
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000159IDA-protein phosphatase type 2A complex17055435
GO:0000159TAS-protein phosphatase type 2A complex11007961
GO:0000775IDA-chromosome, centromeric region16580887
GO:0005634NAS-nucleus11007961
GO:0005739NAS-mitochondrion11007961
GO:0005829TAS-cytosol11007961
GO:0015630NAS-microtubule cytoskeleton11007961
GO:0016020NAS-membrane11007961
GO:0016328IEA-lateral plasma membrane-
GO:0030425IEA-dendrite-
GO:0070062IDA-extracellular exosome23533145
GO ID Evidence Qualifier GO_term References
GO:0003823IPI-antigen binding9847399
GO:0004722IEA-protein serine/threonine phosphatase activity-
GO:0005515IPI-protein binding8617797
GO:0019888TAS-protein phosphatase regulator activity11007961
GO:0046982IPI-protein heterodimerization activity9847399
GO ID Evidence Qualifier GO_term References
GO:0000086TAS-G2/M transition of mitotic cell cycle-
GO:0000184TAS-nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-
GO:0000188NAS-inactivation of MAPK activity11007961
GO:0006275NAS-regulation of DNA replication11007961
GO:0006355NAS-regulation of transcription, DNA-templated11007961
GO:0006461TAS-protein complex assembly9989501
GO:0006470TAS-protein dephosphorylation11007961
GO:0006672NAS-ceramide metabolic process11007961
GO:0006915TAS-apoptotic process11007961
GO:0007059IDA-chromosome segregation16580887
GO:0007084TAS-mitotic nuclear envelope reassembly-
GO:0007143IEA-female meiotic nuclear division-
GO:0008380NAS-RNA splicing11007961
GO:0010033NAS-response to organic substance11007961
GO:0019932NAS-second-messenger-mediated signaling11007961
GO:0030111NAS-regulation of Wnt signaling pathway11007961
GO:0030155NAS-regulation of cell adhesion11007961
GO:0030308NAS-negative regulation of cell growth11007961
GO:0040008NAS-regulation of growth11360189
GO:0042532NAS-negative regulation of tyrosine phosphorylation of STAT protein11007961
GO:0045595NAS-regulation of cell differentiation11360189
GO:0051232IEA-meiotic spindle elongation-
GO:0051306IEA-mitotic sister chromatid separation-
GO:0051754IEA-meiotic sister chromatid cohesion, centromeric-
GO:0070262IEA-peptidyl-serine dephosphorylation-
GO:0097711TAS-ciliary basal body docking-
GO:1903538IEA-regulation of meiotic cell cycle process involved in oocyte maturation-
GO:2001241IEA-positive regulation of extrinsic apoptotic signaling pathway in absence of ligand-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PPP2R1AMCC11033317353931 Affinity Capture-MS
PPP2R1AMCC11151017353931 Affinity Capture-MS
PPP2R1AMLH111043817148452 Affinity Capture-MS
PPP2R1AMLH111151017148452 Affinity Capture-MS
PPP2R1APMS111151017148452 Affinity Capture-Western
PPP2R1APMS111139117148452 Affinity Capture-Western
PPP2R1APPP2CA11150712370081 18782753 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PPP2R1APPP2CA11151012370081 18782753 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PPP2R1APPP2CB11150812370081 18782753 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PPP2R1APPP2CB11151012370081 18782753 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PPP2R3BPPP2R1A11817912370081 18782753 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PPP2R3BPPP2R1A11151012370081 18782753 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PPP2R2APPP2R1A11151212370081 18782753 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PPP2R2APPP2R1A11151012370081 18782753 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PPP2R5APPP2R1A11151712370081 18782753 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PPP2R5APPP2R1A11151012370081 18782753 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
ARIH2PPP2R1A11569416169070 Two-hybrid
ARIH2PPP2R1A11151016169070 Two-hybrid
PPP4CPPP2R1A11152317353931 18715871 Affinity Capture-MS
PPP4CPPP2R1A11151017353931 18715871 Affinity Capture-MS
CTNNBIP1PPP2R1A12131317353931 Affinity Capture-MS
CTNNBIP1PPP2R1A11151017353931 Affinity Capture-MS
STK24PPP2R1A11401117353931 18782753 Affinity Capture-MS
STK24PPP2R1A11151017353931 18782753 Affinity Capture-MS
IKBKEPPP2R1A11151017353931 Affinity Capture-MS
IKBKEPPP2R1A11500017353931 Affinity Capture-MS
STK25PPP2R1A11575718782753 Affinity Capture-MS
STK25PPP2R1A11151018782753 Affinity Capture-MS
PDCD10PPP2R1A11640018782753 Affinity Capture-MS
PDCD10PPP2R1A11151018782753 Affinity Capture-MS
MOBKL3PPP2R1A11736918782753 Affinity Capture-MS
MOBKL3PPP2R1A11151018782753 Affinity Capture-MS
STRN4PPP2R1A11894118782753 Affinity Capture-MS
STRN4PPP2R1A11151018782753 Affinity Capture-MS
STRN3PPP2R1A11899918782753 Affinity Capture-MS
STRN3PPP2R1A11151018782753 Affinity Capture-MS
PPME1PPP2R1A11952418782753 Affinity Capture-MS
PPME1PPP2R1A11151018782753 Affinity Capture-MS
MST4PPP2R1A11972218782753 Affinity Capture-MS
MST4PPP2R1A11151018782753 Affinity Capture-MS
PPP2R1BPPP2R1A11151118782753 Affinity Capture-MS
PPP2R1BPPP2R1A11151018782753 Affinity Capture-MS
PPP2R2CPPP2R1A11151418782753 Affinity Capture-MS
PPP2R2CPPP2R1A11151018782753 Affinity Capture-MS
PPP2R5CPPP2R1A11151918782753 Affinity Capture-MS
PPP2R5CPPP2R1A11151018782753 Affinity Capture-MS
PPP2R5DPPP2R1A11152018782753 Affinity Capture-MS
PPP2R5DPPP2R1A11151018782753 Affinity Capture-MS
PPP2R5EPPP2R1A11152118782753 Affinity Capture-MS
PPP2R5EPPP2R1A11151018782753 Affinity Capture-MS
PPP2R2DPPP2R1A12094618782753 Affinity Capture-MS
PPP2R2DPPP2R1A11151018782753 Affinity Capture-MS
STRNPPP2R1A11267418782753 Affinity Capture-MS
STRNPPP2R1A11151018782753 Affinity Capture-MS
SIKE1PPP2R1A12313618782753 Affinity Capture-MS
SIKE1PPP2R1A11151018782753 Affinity Capture-MS
TRAF3IP3PPP2R1A12324918782753 Affinity Capture-MS
TRAF3IP3PPP2R1A11151018782753 Affinity Capture-MS
CTTNBP2PPP2R1A11151018782753 Affinity Capture-MS
CTTNBP2PPP2R1A12384218782753 Affinity Capture-MS
PPFIA2PPP2R1A11407118782753 Affinity Capture-MS
PPFIA2PPP2R1A11151018782753 Affinity Capture-MS
PPFIA1PPP2R1A11407218782753 Affinity Capture-MS
PPFIA1PPP2R1A11151018782753 Affinity Capture-MS
CTTNBP2NLPPP2R1A12100018782753 Affinity Capture-MS; Affinity Capture-Western
CTTNBP2NLPPP2R1A11151018782753 Affinity Capture-MS; Affinity Capture-Western
FAM40APPP2R1A12449718782753 Affinity Capture-MS; Affinity Capture-Western
FAM40APPP2R1A11151018782753 Affinity Capture-MS; Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
PPP2R1Ars874421 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1926334
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2700'