AutismKB 2.0

Annotation Details for PPP3CA


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Basic Information Top
Gene Symbol:PPP3CA ( CALN,CALNA,CALNA1,CCN1,CNA1,PPP2B )
Gene Full Name: protein phosphatase 3, catalytic subunit, alpha isozyme
Band: 4q24
Quick LinksEntrez ID:5530; OMIM: 114105; Uniprot ID:PP2BA_HUMAN; ENSEMBL ID: ENSG00000138814; HGNC ID: 9314
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005739IEA-mitochondrion-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005955IDA-calcineurin complex12357034
GO:0005955NAS-calcineurin complex8392375
GO:0030018IEA-Z disc-
GO:0042383IEA-sarcolemma-
GO:0098794IEA-postsynapse-
GO ID Evidence Qualifier GO_term References
GO:0004722NAS-protein serine/threonine phosphatase activity8392375
GO:0005509NAS-calcium ion binding8392375
GO:0005515IPI-protein binding8524402
GO:0005516IDA-calmodulin binding11005320
GO:0005516NAS-calmodulin binding8392375
GO:0008144IDA-drug binding11005320
GO:0016018IDA-cyclosporin A binding12357034
GO:0019899IDA-enzyme binding11005320
GO:0033192IDA-calmodulin-dependent protein phosphatase activity18815128
GO:0033192TAS-calmodulin-dependent protein phosphatase activity2556704
GO:0046982IEA-protein heterodimerization activity-
GO:0046983IPI-protein dimerization activity11005320
GO ID Evidence Qualifier GO_term References
GO:0000082IEA-G1/S transition of mitotic cell cycle-
GO:0001975IEA-response to amphetamine-
GO:0006470IDA-protein dephosphorylation18815128
GO:0006470NAS-protein dephosphorylation8392375
GO:0006606IEA-protein import into nucleus-
GO:0006816IEA-calcium ion transport-
GO:0007223TAS-Wnt signaling pathway, calcium modulating pathway-
GO:0014883IEA-transition between fast and slow fiber-
GO:0014898IEA-cardiac muscle hypertrophy in response to stress-
GO:0016311TAS-dephosphorylation2556704
GO:0033173IDA-calcineurin-NFAT signaling cascade22688515
GO:0033555IEA-multicellular organismal response to stress-
GO:0035562IEA-negative regulation of chromatin binding-
GO:0035690IDA-cellular response to drug11005320
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0042110TAS-T cell activation11005320
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter22688515
GO:0046676IEA-negative regulation of insulin secretion-
GO:0048741IEA-skeletal muscle fiber development-
GO:0050774IEA-negative regulation of dendrite morphogenesis-
GO:0050804IEA-modulation of synaptic transmission-
GO:0051091IEA-positive regulation of sequence-specific DNA binding transcription factor activity-
GO:0051533IDA-positive regulation of NFAT protein import into nucleus22688515
GO:0051592IDA-response to calcium ion18815128
GO:0060079IEA-excitatory postsynaptic potential-
GO:0071333IEA-cellular response to glucose stimulus-
GO:1903244IEA-positive regulation of cardiac muscle hypertrophy in response to stress-
GO:1903799IEA-negative regulation of production of miRNAs involved in gene silencing by miRNA-
GO:1905205IEA-positive regulation of connective tissue replacement-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PPP3CAADRB21115229880537 Co-fractionation
PPP3CAADRB21066639880537 Co-fractionation
PPP3CABCL21115229109491 Affinity Capture-Western
PPP3CABCL21070689109491 Affinity Capture-Western
PPP3CARCAN111152210861295 Affinity Capture-Western; Two-hybrid
PPP3CARCAN110816110861295 Affinity Capture-Western; Two-hybrid
PPP3CAPPIA11152212218175 Co-crystal Structure
PPP3CAPPIA11147412218175 Co-crystal Structure
CABIN1PPP3CA1115229655484 Two-hybrid
CABIN1PPP3CA1170709655484 Two-hybrid
AKAP5PPP3CA1115229765270 Affinity Capture-Western; Two-hybrid
AKAP5PPP3CA1148749765270 Affinity Capture-Western; Two-hybrid
MYOZ2PPP3CA11152211114196 Affinity Capture-Western
MYOZ2PPP3CA11972611114196 Affinity Capture-Western
MYOZ1PPP3CA11152211114196 Affinity Capture-Western
MYOZ1PPP3CA12184911114196 Affinity Capture-Western
RCAN2PPP3CA11152212102656 Reconstituted Complex
RCAN2PPP3CA11552512102656 Reconstituted Complex
C16orf74PPP3CA11152216189514 Two-hybrid
C16orf74PPP3CA13566316189514 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
PPP3CArs2044041 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
PPP3CAPPP3CA_CA31-SNP, PPP3CA_casFP1-SNP, PPP3CA_casFP2-SNP, rs1506801, rs2659541, rs2695217, rs2850326, rs2851061, rs3789753, rs3804357, rs3804397, rs3804420, rs756317, rs920559 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:107164
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-091113-24'