AutismKB 2.0

Annotation Details for PPP5C


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Basic Information Top
Gene Symbol:PPP5C ( FLJ36922,PP5,PPP5 )
Gene Full Name: protein phosphatase 5, catalytic subunit
Band: 19q13.32
Quick LinksEntrez ID:5536; OMIM: 600658; Uniprot ID:PPP5_HUMAN; ENSEMBL ID: ENSG00000011485; HGNC ID: 9322
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634TAS-nucleus7925273
GO:0005654TAS-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IEA-plasma membrane-
GO:0043204IEA-perikaryon-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0043234IDA-protein complex23184943
GO:1990635IEA-proximal dendrite-
GO ID Evidence Qualifier GO_term References
GO:0001965IEA-G-protein alpha-subunit binding-
GO:0003723IEA-RNA binding-
GO:0004721ISS-phosphoprotein phosphatase activity9383998
GO:0004722TAS-protein serine/threonine phosphatase activity-
GO:0004871IMP-signal transducer activity12761501
GO:0005515IPI-protein binding9383998
GO:0005524IDA-ATP binding23184943
GO:0008017IEA-microtubule binding-
GO:0008289IEA-lipid binding-
GO:0042802IPI-identical protein binding21360678
GO:0043531IDA-ADP binding23184943
GO:0046872IEA-metal ion binding-
GO:0051879IPI-Hsp90 protein binding15713458
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000278TAS-mitotic cell cycle7925273
GO:0001933IEA-negative regulation of protein phosphorylation-
GO:0006281IEA-DNA repair-
GO:0006351TAS-transcription, DNA-templated7925273
GO:0006470TAS-protein dephosphorylation7925273
GO:0010288IEA-response to lead ion-
GO:0016576IEA-histone dephosphorylation-
GO:0043123IMP-positive regulation of I-kappaB kinase/NF-kappaB signaling12761501
GO:0043278IEA-response to morphine-
GO:0051291IEA-protein heterooligomerization-
GO:0070301IEA-cellular response to hydrogen peroxide-
GO:0071276IEA-cellular response to cadmium ion-
GO:1901215IEA-negative regulation of neuron death-
GO:2000324IEA-positive regulation of glucocorticoid receptor signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PPP5CCDC271115289405394 Reconstituted Complex
PPP5CCDC271074319405394 Reconstituted Complex
PPP5CCRY21115289383998 Reconstituted Complex; Two-hybrid
PPP5CCRY21077989383998 Reconstituted Complex; Two-hybrid
PPP5CCSE1L10782116169070 Two-hybrid
PPP5CCSE1L11152816169070 Two-hybrid
PPP5CEGFR11152820029029 PCA
PPP5CEGFR10827620029029 PCA
PPP5CGNA1211152812176367 Affinity Capture-Western; Reconstituted Complex
PPP5CGNA1210903012176367 Affinity Capture-Western; Reconstituted Complex
PPP5CHSPA411152815383005 Affinity Capture-MS
PPP5CHSPA410954015383005 Affinity Capture-MS
PPP5CHSP90AA111152815383005 Affinity Capture-MS
PPP5CHSP90AA110955215383005 Affinity Capture-MS
PPP5CMAP3K511152811689443 Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression
PPP5CMAP3K511038111689443 Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression
GNA13PPP5C11152812176367 Reconstituted Complex
GNA13PPP5C11591412176367 Reconstituted Complex
PHLPP1PPP5C11152819615732 Affinity Capture-MS
PHLPP1PPP5C11684319615732 Affinity Capture-MS
USP49PPP5C11152819615732 Affinity Capture-MS
USP49PPP5C11738219615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:102666
  • Data Attributes: MGI curated and HomoloGene calculated
No data