AutismKB 2.0

Annotation Details for LGR4


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Basic Information Top
Gene Symbol:LGR4 ( GPR48 )
Gene Full Name: leucine-rich repeat-containing G protein-coupled receptor 4
Band: 11p14.1
Quick LinksEntrez ID:55366; OMIM: 606666; Uniprot ID:LGR4_HUMAN; ENSEMBL ID: ENSG00000205213; HGNC ID: 13299
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane22815884
GO ID Evidence Qualifier GO_term References
GO:0004888IDA-transmembrane signaling receptor activity21727895
GO:0004930IDANOTG-protein coupled receptor activity22815884
GO:0005515IPI-protein binding21727895
GO ID Evidence Qualifier GO_term References
GO:0001649ISS-osteoblast differentiation-
GO:0001942IEA-hair follicle development-
GO:0007186IEA-G-protein coupled receptor signaling pathway-
GO:0007283ISS-spermatogenesis-
GO:0030282ISS-bone mineralization-
GO:0030539IEA-male genitalia development-
GO:0032922ISS-circadian regulation of gene expression-
GO:0034122ISS-negative regulation of toll-like receptor signaling pathway-
GO:0036335IEA-intestinal stem cell homeostasis-
GO:0045087IEA-innate immune response-
GO:0045892IEA-negative regulation of transcription, DNA-templated-
GO:0045893IEA-positive regulation of transcription, DNA-templated-
GO:0046849ISS-bone remodeling-
GO:0048565IEA-digestive tract development-
GO:0050710ISS-negative regulation of cytokine secretion-
GO:0061290IEA-canonical Wnt signaling pathway involved in metanephric kidney development-
GO:0072202IEA-cell differentiation involved in metanephros development-
GO:0072224IEA-metanephric glomerulus development-
GO:0072282IEA-metanephric nephron tubule morphogenesis-
GO:0090190IEA-positive regulation of branching involved in ureteric bud morphogenesis-
GO:0090263IDA-positive regulation of canonical Wnt signaling pathway22815884
GO:2001013IEA-epithelial cell proliferation involved in renal tubule morphogenesis-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1891468
  • Data Attributes: MGI curated and HomoloGene calculated
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018