AutismKB 2.0

Annotation Details for PLXNA3


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Basic Information Top
Gene Symbol:PLXNA3 ( 6.3,HSSEXGENE,PLEXIN-A3,PLXN3,PLXN4,SEX,XAP-6 )
Gene Full Name: plexin A3
Band: Xq28
Quick LinksEntrez ID:55558; OMIM: 300022; Uniprot ID:PLXA3_HUMAN; ENSEMBL ID: ENSG00000130827; HGNC ID: 9101
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0002116TAS-semaphorin receptor complex19909241
GO:0005634IDA-nucleus-
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0016020TAS-membrane8570614
GO:0016021IEA-integral component of membrane-
GO:0030054IDA-cell junction-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO ID Evidence Qualifier GO_term References
GO:0004888NAS-transmembrane signaling receptor activity8570614
GO:0005515IPI-protein binding20138877
GO:0017154IEA-semaphorin receptor activity-
GO ID Evidence Qualifier GO_term References
GO:0007275TAS-multicellular organism development8570614
GO:0021612IEA-facial nerve structural organization-
GO:0021637IEA-trigeminal nerve structural organization-
GO:0021766IEA-hippocampus development-
GO:0021785IBA-branchiomotor neuron axon guidance-
GO:0021860IEA-pyramidal neuron development-
GO:0048841IBA-regulation of axon extension involved in axon guidance-
GO:0048843IEA-negative regulation of axon extension involved in axon guidance-
GO:0050919IEA-negative chemotaxis-
GO:0051495IEA-positive regulation of cytoskeleton organization-
GO:0071526NAS-semaphorin-plexin signaling pathway19909241
GO:1902287IEA-semaphorin-plexin signaling pathway involved in axon guidance-
GO:1990138IEA-neuron projection extension-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:107683
  • Data Attributes: MGI curated and HomoloGene calculated
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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