AutismKB 2.0

Annotation Details for PRKAA1


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Basic Information Top
Gene Symbol:PRKAA1 ( AMPK,AMPKa1,MGC33776,MGC57364 )
Gene Full Name: protein kinase, AMP-activated, alpha 1 catalytic subunit
Band: 5p13.1
Quick LinksEntrez ID:5562; OMIM: 602739; Uniprot ID:AAPK1_HUMAN; ENSEMBL ID: ENSG00000132356; HGNC ID: 9376
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IC-intracellular8557660
GO:0005622IMP-intracellular26103054
GO:0005634IBA-nucleus-
GO:0005634ISS-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0005737IBA-cytoplasm-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0016324IEA-apical plasma membrane-
GO:0016607IDA-nuclear speck-
GO:0031588ISS-nucleotide-activated protein kinase complex-
GO ID Evidence Qualifier GO_term References
GO:0003682ISS-chromatin binding-
GO:0004672IDA-protein kinase activity17028174
GO:0004679IDA-AMP-activated protein kinase activity18439900
GO:0004691NAS-cAMP-dependent protein kinase activity8557660
GO:0005515IPI-protein binding16306228
GO:0005524IEA-ATP binding-
GO:0008022IEA-protein C-terminus binding-
GO:0019900IEA-kinase binding-
GO:0035174ISS-histone serine kinase activity-
GO:0046872IEA-metal ion binding-
GO:0047322IEA-[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity-
GO:0050321IEA-tau-protein kinase activity-
GO:0050405IEA-[acetyl-CoA carboxylase] kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0000187NAS-activation of MAPK activity11546797
GO:0001666NAS-response to hypoxia8557660
GO:0006006IEA-glucose metabolic process-
GO:0006351IEA-transcription, DNA-templated-
GO:0006355IEA-regulation of transcription, DNA-templated-
GO:0006468IDA-protein phosphorylation17028174
GO:0006633IEA-fatty acid biosynthetic process-
GO:0006695IEA-cholesterol biosynthetic process-
GO:0007050TAS-cell cycle arrest-
GO:0007165TAS-signal transduction8557660
GO:0008284IEA-positive regulation of cell proliferation-
GO:0008610ISS-lipid biosynthetic process-
GO:0009411IEA-response to UV-
GO:0009631IEA-cold acclimation-
GO:0010332ISS-response to gamma radiation-
GO:0010508IDA-positive regulation of autophagy22012985
GO:0010508IMP-positive regulation of autophagy26103054
GO:0010508ISS-positive regulation of autophagy-
GO:0010628IDA-positive regulation of gene expression17028174
GO:0014823IEA-response to activity-
GO:0016055IEA-Wnt signaling pathway-
GO:0016236TAS-macroautophagy-
GO:0016241TAS-regulation of macroautophagy-
GO:0019395IEA-fatty acid oxidation-
GO:0031000IEA-response to caffeine-
GO:0031669ISS-cellular response to nutrient levels-
GO:0032007ISS-negative regulation of TOR signaling-
GO:0033135IEA-regulation of peptidyl-serine phosphorylation-
GO:0035404IEA-histone-serine phosphorylation-
GO:0035556IBA-intracellular signal transduction-
GO:0042149ISS-cellular response to glucose starvation-
GO:0042593ISS-glucose homeostasis-
GO:0042752ISS-regulation of circadian rhythm-
GO:0043066ISS-negative regulation of apoptotic process-
GO:0045542NAS-positive regulation of cholesterol biosynthetic process8557660
GO:0045821ISS-positive regulation of glycolytic process-
GO:0046318NAS-negative regulation of glucosylceramide biosynthetic process11165240
GO:0048511IEA-rhythmic process-
GO:0048643IEA-positive regulation of skeletal muscle tissue development-
GO:0050995ISS-negative regulation of lipid catabolic process-
GO:0051291IEA-protein heterooligomerization-
GO:0055089ISS-fatty acid homeostasis-
GO:0060627IEA-regulation of vesicle-mediated transport-
GO:0061762IC-CAMKK-AMPK signaling cascade22012985
GO:0061762IMP-CAMKK-AMPK signaling cascade26103054
GO:0070301IEA-cellular response to hydrogen peroxide-
GO:0071361IEA-cellular response to ethanol-
GO:0071380IEA-cellular response to prostaglandin E stimulus-
GO:0071417IEA-cellular response to organonitrogen compound-
GO:0071456IEA-cellular response to hypoxia-
GO:1901563IEA-response to camptothecin-
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
GO:2000505ISS-regulation of energy homeostasis-
GO:2001274IEA-negative regulation of glucose import in response to insulin stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PRKAA1PARP111154920562859 Affinity Capture-MS
PRKAA1PARP110665220562859 Affinity Capture-MS
PRKAA1CFTR11154910862786 Reconstituted Complex
PRKAA1CFTR10750610862786 Reconstituted Complex
PRKAA1FMR111154920562859 Affinity Capture-MS
PRKAA1FMR110861920562859 Affinity Capture-MS
PRKAA1MTOR11154914970221 Protein-peptide
PRKAA1MTOR10875714970221 Protein-peptide
PRKAA1PA2G411107520562859 Affinity Capture-MS
PRKAA1PA2G411154920562859 Affinity Capture-MS
PRKAG1PRKAA111154910698692 20562859 Affinity Capture-MS; Two-hybrid
PRKAG1PRKAA111155810698692 20562859 Affinity Capture-MS; Two-hybrid
TSC2PRKAA111310014651849 15261145 Affinity Capture-Western; Reconstituted Complex
TSC2PRKAA111154914651849 15261145 Affinity Capture-Western; Reconstituted Complex
FNIP1PRKAA112517517028174 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
FNIP1PRKAA111154917028174 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
G3BP1PRKAA111154920562859 Affinity Capture-MS
G3BP1PRKAA111544820562859 Affinity Capture-MS
SUPT16HPRKAA111636720562859 Affinity Capture-MS
SUPT16HPRKAA111154920562859 Affinity Capture-MS
RPL35PRKAA111154920562859 Affinity Capture-MS
RPL35PRKAA111639220562859 Affinity Capture-MS
SND1PRKAA111797420562859 Affinity Capture-MS
SND1PRKAA111154920562859 Affinity Capture-MS
PRKAG2PRKAA111953120562859 Affinity Capture-MS
PRKAG2PRKAA111154920562859 Affinity Capture-MS
PRKAA2PRKAA111154920562859 Affinity Capture-MS
PRKAA2PRKAA111155020562859 Affinity Capture-MS
PRKAB1PRKAA111155120562859 Affinity Capture-MS
PRKAB1PRKAA111154920562859 Affinity Capture-MS
PRKAB2PRKAA111155220562859 Affinity Capture-MS
PRKAB2PRKAA111154920562859 Affinity Capture-MS
DDA1PRKAA112248520562859 Affinity Capture-MS
DDA1PRKAA111154920562859 Affinity Capture-MS
ULK1PRKAA111154920562859 Affinity Capture-MS
ULK1PRKAA111399620562859 Affinity Capture-MS
FXR2PRKAA111489020562859 Affinity Capture-MS
FXR2PRKAA111154920562859 Affinity Capture-MS
EIF5BPRKAA111154920562859 Affinity Capture-MS
EIF5BPRKAA111502420562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
PRKAA1rs29742, rs3805492, rs466108 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:2145955
  • Data Attributes: MGI curated and HomoloGene calculated
No data