AutismKB 2.0

Annotation Details for VPS35


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Basic Information Top
Gene Symbol:VPS35 ( DKFZp434E1211,DKFZp434P1672,FLJ10752,FLJ13588,FLJ20388,MEM3 )
Gene Full Name: vacuolar protein sorting 35 homolog (S. cerevisiae)
Band: 16q11.2
Quick LinksEntrez ID:55737; OMIM: 601501; Uniprot ID:VPS35_HUMAN; ENSEMBL ID: ENSG00000069329; HGNC ID: 13487
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005739IDAcolocalizes_withmitochondrion26618722
GO:0005764IDA-lysosome-
GO:0005765IDA-lysosomal membrane17897319
GO:0005768IDA-endosome15078903
GO:0005769IDA-early endosome18160348
GO:0005770IEA-late endosome-
GO:0005829IDA-cytosol11102511
GO:0005829TAS-cytosol-
GO:0010008IDA-endosome membrane27385586
GO:0014069IEA-postsynaptic density-
GO:0030904IDA-retromer complex11102511
GO:0030904NAS-retromer complex18193037
GO:0030904TAS-retromer complex17239604
GO:0030906IDA-retromer, cargo-selective complex27385586
GO:0030906NAS-retromer, cargo-selective complex26220253
GO:0043005IEA-neuron projection-
GO:0043025IEA-neuronal cell body-
GO:0048471IEA-perinuclear region of cytoplasm-
GO:0070062IDA-extracellular exosome19056867
GO:0097422IDA-tubular endosome15078903
GO:0099073IDA-mitochondrion-derived vesicle26618722
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding11102511
GO:0008565IEA-protein transporter activity-
GO:0031748IPI-D1 dopamine receptor binding27460146
GO ID Evidence Qualifier GO_term References
GO:0007040IEA-lysosome organization-
GO:0010628IDA-positive regulation of gene expression26618722
GO:0010629IEA-negative regulation of gene expression-
GO:0010821IGI-regulation of mitochondrion organization26618722
GO:0016055NAS-Wnt signaling pathway24115276
GO:0016055TAS-Wnt signaling pathway-
GO:0016241TAS-regulation of macroautophagy26172538
GO:0031647IMP-regulation of protein stability18193037
GO:0031648IEA-protein destabilization-
GO:0032268IDA-regulation of cellular protein metabolic process26618722
GO:0032463IEA-negative regulation of protein homooligomerization-
GO:0033365IEA-protein localization to organelle-
GO:0042147IMP-retrograde transport, endosome to Golgi15078903
GO:0042147NAS-retrograde transport, endosome to Golgi11102511
GO:0043653IMP-mitochondrial fragmentation involved in apoptotic process26618722
GO:0045056IDA-transcytosis15247922
GO:0050882IEA-voluntary musculoskeletal movement-
GO:0060161IDA-positive regulation of dopamine receptor signaling pathway27460146
GO:0061357IEA-positive regulation of Wnt protein secretion-
GO:0090141IMP-positive regulation of mitochondrial fission26618722
GO:0090263IEA-positive regulation of canonical Wnt signaling pathway-
GO:0090326IEA-positive regulation of locomotion involved in locomotory behavior-
GO:0099074IMP-mitochondrion to lysosome transport26618722
GO:0099639IDA-neurotransmitter receptor transport, endosome to plasma membrane27460146
GO:1901215IEA-negative regulation of neuron death-
GO:1902823IMP-negative regulation of late endosome to lysosome transport23563491
GO:1902950IMP-regulation of dendritic spine maintenance26618722
GO:1903181IEA-positive regulation of dopamine biosynthetic process-
GO:1903364IGI-positive regulation of cellular protein catabolic process25533483
GO:1903828IEA-negative regulation of cellular protein localization-
GO:1905166IEA-negative regulation of lysosomal protein catabolic process-
GO:1990126IMP-retrograde transport, endosome to plasma membrane20164305
GO:2000331IMP-regulation of terminal button organization26618722
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
VPS35MCC12085517353931 Affinity Capture-MS
VPS35MCC11033317353931 Affinity Capture-MS
USP43VPS3512588419615732 Affinity Capture-MS
USP43VPS3512085519615732 Affinity Capture-MS
USP32VPS3512418919615732 Affinity Capture-MS
USP32VPS3512085519615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
VPS35rs700582, rs794279 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1890467
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-2042'