AutismKB 2.0

Annotation Details for PRKCA


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Basic Information Top
Gene Symbol:PRKCA ( AAG6,MGC129900,MGC129901,PKC-alpha,PKCA,PRKACA )
Gene Full Name: protein kinase C, alpha
Band: 17q24.2
Quick LinksEntrez ID:5578; OMIM: 176960; Uniprot ID:KPCA_HUMAN; ENSEMBL ID: ENSG00000154229; HGNC ID: 9393
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm15632189
GO:0005739IDA-mitochondrion20833797
GO:0005783IDA-endoplasmic reticulum18556656
GO:0005829IDA-cytosol17983652
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane15632189
GO:0005886TAS-plasma membrane-
GO:0031966IEA-mitochondrial membrane-
GO:0048471ISS-perinuclear region of cytoplasm-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity10770950
GO:0004674EXP-protein serine/threonine kinase activity7520444
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004697ISS-protein kinase C activity-
GO:0004697TAS-protein kinase C activity-
GO:0004698TAS-calcium-dependent protein kinase C activity-
GO:0005515IPI-protein binding12571249
GO:0005524IEA-ATP binding-
GO:0008270IEA-zinc ion binding-
GO:0019899IDA-enzyme binding18556656
GO:0035403IDA-histone kinase activity (H3-T6 specific)20228790
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0001938IMP-positive regulation of endothelial cell proliferation11909826
GO:0002159IMP-desmosome assembly18474624
GO:0006468IDA-protein phosphorylation10770950
GO:0007077TAS-mitotic nuclear envelope disassembly-
GO:0007155IEA-cell adhesion-
GO:0007190ISS-activation of adenylate cyclase activity-
GO:0007194ISS-negative regulation of adenylate cyclase activity-
GO:0007411TAS-axon guidance-
GO:0010595IMP-positive regulation of endothelial cell migration11909826
GO:0010613ISS-positive regulation of cardiac muscle hypertrophy-
GO:0018105IBA-peptidyl-serine phosphorylation-
GO:0030168TAS-platelet activation-
GO:0030335IMP-positive regulation of cell migration23990668
GO:0031666IMP-positive regulation of lipopolysaccharide-mediated signaling pathway9830023
GO:0034351IMP-negative regulation of glial cell apoptotic process9927633
GO:0035408IDA-histone H3-T6 phosphorylation20228790
GO:0035556IBA-intracellular signal transduction-
GO:0038128TAS-ERBB2 signaling pathway-
GO:0043488TAS-regulation of mRNA stability-
GO:0043536IDA-positive regulation of blood vessel endothelial cell migration20011604
GO:0045651ISS-positive regulation of macrophage differentiation-
GO:0045766IMP-positive regulation of angiogenesis11909826
GO:0045785IMP-positive regulation of cell adhesion11909826
GO:0045931IMP-positive regulation of mitotic cell cycle10848585
GO:0050796TAS-regulation of insulin secretion-
GO:0070374ISS-positive regulation of ERK1 and ERK2 cascade-
GO:0070555IMP-response to interleukin-119281832
GO:0090330IDA-regulation of platelet aggregation12724315
GO:0097190TAS-apoptotic signaling pathway10825394
GO:2000707ISS-positive regulation of dense core granule biogenesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PRKCAATP1A111156415069082 Biochemical Activity
PRKCAATP1A110696615069082 Biochemical Activity
PRKCAAVPR1A10703310858434 Affinity Capture-Western
PRKCAAVPR1A11156410858434 Affinity Capture-Western
PRKCAAVPR1B10703410858434 Affinity Capture-Western
PRKCAAVPR1B11156410858434 Affinity Capture-Western
PRKCAAVPR210703510858434 Affinity Capture-Western
PRKCAAVPR211156410858434 Affinity Capture-Western
PRKCAKLF510715312682370 Biochemical Activity
PRKCAKLF511156412682370 Biochemical Activity
PRKCAC1QBP11156410831594 Affinity Capture-Western; Reconstituted Complex
PRKCAC1QBP10716910831594 Affinity Capture-Western; Reconstituted Complex
PRKCACD910736611325968 Affinity Capture-Western
PRKCACD911156411325968 Affinity Capture-Western
PRKCACD5311156411325968 Affinity Capture-Western
PRKCACD5310740111325968 Affinity Capture-Western
PRKCADLG411156411937501 Affinity Capture-Western
PRKCADLG410808611937501 Affinity Capture-Western
PRKCAEGFR11156412878187 Affinity Capture-Western
PRKCAEGFR10827612878187 Affinity Capture-Western
PRKCAGABRB310883612595241 Reconstituted Complex
PRKCAGABRB311156412595241 Reconstituted Complex
PRKCAGJA110896411273731 Affinity Capture-Western
PRKCAGJA111156411273731 Affinity Capture-Western
PRKCAGRM710917411007882 Affinity Capture-Western
PRKCAGRM711156411007882 Affinity Capture-Western
PRKCAGSK3B1091871324914 Biochemical Activity
PRKCAGSK3B1115641324914 Biochemical Activity
PRKCAHMGA110940210889043 Biochemical Activity
PRKCAHMGA111156410889043 Biochemical Activity
PRKCAITGB110989412138200 12435334 Affinity Capture-Western
PRKCAITGB111156412138200 12435334 Affinity Capture-Western
PRKCALMNA11156412112001 Protein-peptide
PRKCALMNA11018612112001 Protein-peptide
PRKCALMNB111156412135703 Reconstituted Complex
PRKCALMNB111018712135703 Reconstituted Complex
PRKCAMGMT11156410667577 Biochemical Activity
PRKCAMGMT11041110667577 Biochemical Activity
PRKCAOGG111101812034821 Affinity Capture-Western; Biochemical Activity
PRKCAOGG111156412034821 Affinity Capture-Western; Biochemical Activity
PRKCAPLD111135312839565 Affinity Capture-Western
PRKCAPLD111156412839565 Affinity Capture-Western
PRKCAPLD211156411042115 Affinity Capture-Western
PRKCAPLD211135411042115 Affinity Capture-Western
TNP1PRKCA1129959837753 Biochemical Activity
TNP1PRKCA1115649837753 Biochemical Activity
TNP2PRKCA1129969837753 Biochemical Activity
TNP2PRKCA1115649837753 Biochemical Activity
TIAM1PRKCA11293010212259 Biochemical Activity
TIAM1PRKCA11156410212259 Biochemical Activity
YWHAGPRKCA11336410433554 Affinity Capture-Western
YWHAGPRKCA11156410433554 Affinity Capture-Western
HMGA2PRKCA11376310889043 Biochemical Activity
HMGA2PRKCA11156410889043 Biochemical Activity
PICK1PRKCA11484911007882 Affinity Capture-Western
PICK1PRKCA11156411007882 Affinity Capture-Western
RGS2PRKCA11192911063746 Biochemical Activity
RGS2PRKCA11156411063746 Biochemical Activity
AKAP12PRKCA11495811316952 Affinity Capture-Western
AKAP12PRKCA11156411316952 Affinity Capture-Western
EZRPRKCA11327111387207 Affinity Capture-Western
EZRPRKCA11156411387207 Affinity Capture-Western
YWHAZPRKCA11336611950841 Affinity Capture-Western
YWHAZPRKCA11156411950841 Affinity Capture-Western
AFAP1PRKCA12189512134071 Reconstituted Complex
AFAP1PRKCA11156412134071 Reconstituted Complex
GNB2L1PRKCA11156412435334 Affinity Capture-Western
GNB2L1PRKCA11567112435334 Affinity Capture-Western
SLC1A1PRKCA11239612843260 Affinity Capture-Western
SLC1A1PRKCA11156412843260 Affinity Capture-Western
FSCN1PRKCA11250814532112 Affinity Capture-Western; Reconstituted Complex
FSCN1PRKCA11156414532112 Affinity Capture-Western; Reconstituted Complex
HAND1PRKCA11481414636580 Biochemical Activity
HAND1PRKCA11156414636580 Biochemical Activity
HAND2PRKCA11485014636580 Biochemical Activity
HAND2PRKCA11156414636580 Biochemical Activity
HABP4PRKCA11658714699138 Biochemical Activity
HABP4PRKCA11156414699138 Biochemical Activity
TRIM41PRKCA12478017893151 Affinity Capture-Western; Reconstituted Complex
TRIM41PRKCA11156417893151 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
PRKCArs1010546, rs10491201, rs1860985, rs228875, rs3764402, rs3803821, rs3889237, rs4791036, rs62621677, rs62621678, rs62621679, rs6504413, rs7207345, rs7342847, rs759117, rs8074909, rs8074995, rs8464, rs873417, rs9893560, rs9914723 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97595
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050208-100'