AutismKB 2.0

Annotation Details for PRKCB


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Basic Information Top
Gene Symbol:PRKCB ( MGC41878,PKC-beta,PKCB,PRKCB1,PRKCB2 )
Gene Full Name: protein kinase C, beta
Band: 16p12.2-p12.1
Quick LinksEntrez ID:5579; OMIM: 176970; Uniprot ID:KPCB_HUMAN; ENSEMBL ID: ENSG00000166501; HGNC ID: 9395
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus20228790
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm15632189
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane15632189
GO:0005886TAS-plasma membrane-
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0003682IDA-chromatin binding20228790
GO:0004674EXP-protein serine/threonine kinase activity12391145
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004697TAS-protein kinase C activity-
GO:0004698TAS-calcium-dependent protein kinase C activity-
GO:0005080IPI-protein kinase C binding20228790
GO:0005246IEA-calcium channel regulator activity-
GO:0005515IPI-protein binding20228790
GO:0005524IEA-ATP binding-
GO:0008270IEA-zinc ion binding-
GO:0030374IMP-ligand-dependent nuclear receptor transcription coactivator activity20228790
GO:0035403IDA-histone kinase activity (H3-T6 specific)20228790
GO:0042393IDA-histone binding20228790
GO:0050681IDA-androgen receptor binding20228790
GO ID Evidence Qualifier GO_term References
GO:0001666IEA-response to hypoxia-
GO:0002250IEA-adaptive immune response-
GO:0006351IEA-transcription, DNA-templated-
GO:0006357IMP-regulation of transcription from RNA polymerase II promoter20228790
GO:0006468TAS-protein phosphorylation3755548
GO:0006816IEA-calcium ion transport-
GO:0006874IEA-cellular calcium ion homeostasis-
GO:0006915IEA-apoptotic process-
GO:0007077TAS-mitotic nuclear envelope disassembly-
GO:0007165NAS-signal transduction3755548
GO:0010829ISS-negative regulation of glucose transport-
GO:0018105IBA-peptidyl-serine phosphorylation-
GO:0030168TAS-platelet activation-
GO:0030949ISS-positive regulation of vascular endothelial growth factor receptor signaling pathway-
GO:0035408IDA-histone H3-T6 phosphorylation20228790
GO:0035556IBA-intracellular signal transduction-
GO:0042113ISS-B cell activation-
GO:0042953TAS-lipoprotein transport18981301
GO:0043123ISS-positive regulation of I-kappaB kinase/NF-kappaB signaling-
GO:0045766ISS-positive regulation of angiogenesis-
GO:0046627ISS-negative regulation of insulin receptor signaling pathway-
GO:0050853ISS-B cell receptor signaling pathway-
GO:0050861ISS-positive regulation of B cell receptor signaling pathway-
GO:0051092ISS-positive regulation of NF-kappaB transcription factor activity-
GO:0071322IEA-cellular response to carbohydrate stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PRKCBADRBK110666512679936 Affinity Capture-Western; Reconstituted Complex
PRKCBADRBK111156512679936 Affinity Capture-Western; Reconstituted Complex
PRKCBBTK10716012679936 Reconstituted Complex
PRKCBBTK11156512679936 Reconstituted Complex
PRKCBCDK111156511901153 Affinity Capture-Western
PRKCBCDK110742011901153 Affinity Capture-Western
PRKCBCSF2RB10782610490850 Affinity Capture-Western
PRKCBCSF2RB11156510490850 Affinity Capture-Western
PRKCBGNA121090308824244 Biochemical Activity
PRKCBGNA121115658824244 Biochemical Activity
PRKCBHSPA410954016954220 Affinity Capture-Western; Reconstituted Complex
PRKCBHSPA411156516954220 Affinity Capture-Western; Reconstituted Complex
PRKCBLMNB111018711901153 Affinity Capture-Western
PRKCBLMNB111156511901153 Affinity Capture-Western
PRKCBNCAM111076412743109 Affinity Capture-Western
PRKCBNCAM111156512743109 Affinity Capture-Western
PRKCBPDPK111119611376011 Reconstituted Complex
PRKCBPDPK111156511376011 Reconstituted Complex
GNA13PRKCB1159148824244 Biochemical Activity
GNA13PRKCB1115658824244 Biochemical Activity
PDLIM5PRKCB1158578940095 Affinity Capture-Western; Two-hybrid
PDLIM5PRKCB1115658940095 Affinity Capture-Western; Two-hybrid
TIAM1PRKCB11293010212259 Biochemical Activity
TIAM1PRKCB11156510212259 Biochemical Activity
YWHAGPRKCB11336410433554 Affinity Capture-Western
YWHAGPRKCB11156510433554 Affinity Capture-Western
GNB2L1PRKCB11567110480917 Affinity Capture-Western; Reconstituted Complex
GNB2L1PRKCB11156510480917 Affinity Capture-Western; Reconstituted Complex
RGS2PRKCB11192911063746 Biochemical Activity
RGS2PRKCB11156511063746 Biochemical Activity
NCF1PRKCB57572411120743 Affinity Capture-Western
NCF1PRKCB11156511120743 Affinity Capture-Western
RIPK4PRKCB11989911278382 Affinity Capture-Western; Biochemical Activity
RIPK4PRKCB11156511278382 Affinity Capture-Western; Biochemical Activity
AFAP1PRKCB12189512134071 Reconstituted Complex
AFAP1PRKCB11156512134071 Reconstituted Complex
RASGRP3PRKCB11731515213298 Biochemical Activity
RASGRP3PRKCB11156515213298 Biochemical Activity
UBCPRKCB11316416954220 Affinity Capture-Western
UBCPRKCB11156516954220 Affinity Capture-Western
RBCK1PRKCB11586218303026 Biochemical Activity
RBCK1PRKCB11156518303026 Biochemical Activity
IKBKGPRKCB11408920098747 Reconstituted Complex
IKBKGPRKCB11156520098747 Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
STAT3PRKCB30077010446219 An unspecified isoform of PKC-beta interacts with Stat3.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97596
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1178'