AutismKB 2.0

Annotation Details for AXL


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Basic Information Top
Gene Symbol:AXL ( JTK11,UFO )
Gene Full Name: AXL receptor tyrosine kinase
Band: 19q13.2
Quick LinksEntrez ID:558; OMIM: 109135; Uniprot ID:UFO_HUMAN; ENSEMBL ID: ENSG00000167601; HGNC ID: 905
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005615IDA-extracellular space20088931
GO:0005622IEA-intracellular-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane1656220
GO:0009986IDA-cell surface19581412
GO:0044228IDA-host cell surface21529875
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0001618IEA-virus receptor activity-
GO:0001786IDA-phosphatidylserine binding21501828
GO:0004713EXP-protein tyrosine kinase activity22327215
GO:0004714IEA-transmembrane receptor protein tyrosine kinase activity-
GO:0005515IPI-protein binding7854420
GO:0005524IEA-ATP binding-
GO:0032036IEA-myosin heavy chain binding-
GO:0043548IEA-phosphatidylinositol 3-kinase binding-
GO:0046982IEA-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0001764IEA-neuron migration-
GO:0001779IEA-natural killer cell differentiation-
GO:0001961IDA-positive regulation of cytokine-mediated signaling pathway18840707
GO:0001974IEA-blood vessel remodeling-
GO:0006909IDA-phagocytosis21501828
GO:0006954IEA-inflammatory response-
GO:0007165TAS-signal transduction1656220
GO:0007283IEA-spermatogenesis-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0021885IEA-forebrain cell migration-
GO:0030168IEA-platelet activation-
GO:0031100IEA-animal organ regeneration-
GO:0031668IEA-cellular response to extracellular stimulus-
GO:0032689IDA-negative regulation of interferon-gamma production18840707
GO:0032720IEA-negative regulation of tumor necrosis factor production-
GO:0032825IDA-positive regulation of natural killer cell differentiation18840707
GO:0032940IEA-secretion by cell-
GO:0034101IEA-erythrocyte homeostasis-
GO:0034446IEA-substrate adhesion-dependent cell spreading-
GO:0035457IDA-cellular response to interferon-alpha19657094
GO:0042698IEA-ovulation cycle-
GO:0043277IEA-apoptotic cell clearance-
GO:0043491IEA-protein kinase B signaling-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0045087IEA-innate immune response-
GO:0046718IMP-viral entry into host cell21047970
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048469IEP-cell maturation19657094
GO:0048549IMP-positive regulation of pinocytosis21047970
GO:0051250IEA-negative regulation of lymphocyte activation-
GO:0051897IEA-positive regulation of protein kinase B signaling-
GO:0060068IEA-vagina development-
GO:0070301IEA-cellular response to hydrogen peroxide-
GO:0071222IDA-cellular response to lipopolysaccharide19657094
GO:0097028IEP-dendritic cell differentiation19657094
GO:0097350IEA-neutrophil clearance-
GO:2000669IDA-negative regulation of dendritic cell apoptotic process19657094
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GAS6AXL1088918939948 Reconstituted Complex
GAS6AXL1070368939948 Reconstituted Complex
PIK3R1AXL1113139178760 Biochemical Activity
PIK3R1AXL1070369178760 Biochemical Activity
PIK3R2AXL1113149178760 Biochemical Activity
PIK3R2AXL1070369178760 Biochemical Activity
GRB2AXL1070369178760 Far Western
GRB2AXL1091429178760 Far Western
LCKAXL1101249178760 Far Western
LCKAXL1070369178760 Far Western
SRCAXL1125929178760 Far Western
SRCAXL1070369178760 Far Western
TENC1AXL11695112470648 Affinity Capture-Western; Two-hybrid
TENC1AXL10703612470648 Affinity Capture-Western; Two-hybrid
UBCAXL11316415958209 Affinity Capture-Western
UBCAXL10703615958209 Affinity Capture-Western
CBLAXL10731515958209 Affinity Capture-Western
CBLAXL10703615958209 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1347244
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-100812-8'