AutismKB 2.0

Annotation Details for PRKCE


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Basic Information Top
Gene Symbol:PRKCE ( MGC125656,MGC125657,PKCE,nPKC-epsilon )
Gene Full Name: protein kinase C, epsilon
Band: 2p21
Quick LinksEntrez ID:5581; OMIM: 176975; Uniprot ID:KPCE_HUMAN; ENSEMBL ID: ENSG00000171132; HGNC ID: 9401
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005737IDA-cytoplasm15632189
GO:0005739IEA-mitochondrion-
GO:0005783IDA-endoplasmic reticulum18556656
GO:0005794ISScolocalizes_withGolgi apparatus-
GO:0005829IDA-cytosol17603037
GO:0005829TAS-cytosol-
GO:0005856IEA-cytoskeleton-
GO:0005886IDA-plasma membrane15632189
GO:0005886TAS-plasma membrane-
GO:0048471ISS-perinuclear region of cytoplasm-
GO:0071944ISS-cell periphery-
GO ID Evidence Qualifier GO_term References
GO:0003785ISS-actin monomer binding-
GO:0004674IDA-protein serine/threonine kinase activity15695813
GO:0004697IDA-protein kinase C activity18556656
GO:0004697TAS-protein kinase C activity-
GO:0004699IEA-calcium-independent protein kinase C activity-
GO:0004871TAS-signal transducer activity1382605
GO:0005515IPI-protein binding16810323
GO:0005524IEA-ATP binding-
GO:0008047IMP-enzyme activator activity18556656
GO:0019899IDA-enzyme binding18556656
GO:0019899IPI-enzyme binding15632189
GO:0030546IEA-receptor activator activity-
GO:0035276IEA-ethanol binding-
GO:0046872IEA-metal ion binding-
GO:0071889IEA-14-3-3 protein binding-
GO ID Evidence Qualifier GO_term References
GO:0002281IEA-macrophage activation involved in immune response-
GO:0006468IDA-protein phosphorylation18556656
GO:0006915TAS-apoptotic process10438519
GO:0007049IEA-cell cycle-
GO:0007155IEA-cell adhesion-
GO:0007165TAS-signal transduction-
GO:0007202TAS-activation of phospholipase C activity-
GO:0010634IMP-positive regulation of epithelial cell migration17603037
GO:0010763ISS-positive regulation of fibroblast migration-
GO:0010811IEA-positive regulation of cell-substrate adhesion-
GO:0018105IDA-peptidyl-serine phosphorylation15695813
GO:0030168TAS-platelet activation-
GO:0030838ISS-positive regulation of actin filament polymerization-
GO:0031397IEA-negative regulation of protein ubiquitination-
GO:0031663ISS-lipopolysaccharide-mediated signaling pathway-
GO:0032024IEA-positive regulation of insulin secretion-
GO:0032230IEA-positive regulation of synaptic transmission, GABAergic-
GO:0032467IMP-positive regulation of cytokinesis18604201
GO:0035556IBA-intracellular signal transduction-
GO:0035641IEA-locomotory exploration behavior-
GO:0035669ISS-TRAM-dependent toll-like receptor 4 signaling pathway-
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0043123IEA-positive regulation of I-kappaB kinase/NF-kappaB signaling-
GO:0043278IEA-response to morphine-
GO:0043410IEA-positive regulation of MAPK cascade-
GO:0050730IEA-regulation of peptidyl-tyrosine phosphorylation-
GO:0050996IEA-positive regulation of lipid catabolic process-
GO:0051209IEA-release of sequestered calcium ion into cytosol-
GO:0051279IEA-regulation of release of sequestered calcium ion into cytosol-
GO:0051301IEA-cell division-
GO:0061178IEA-regulation of insulin secretion involved in cellular response to glucose stimulus-
GO:0070257IEA-positive regulation of mucus secretion-
GO:0071361IEA-cellular response to ethanol-
GO:0071380IEA-cellular response to prostaglandin E stimulus-
GO:0071456IEA-cellular response to hypoxia-
GO:0090303IMP-positive regulation of wound healing17603037
GO:1903078TAS-positive regulation of protein localization to plasma membrane22732145
GO:2000273IEA-positive regulation of receptor activity-
GO:2000650TAS-negative regulation of sodium ion transmembrane transporter activity19193863
GO:2001031IMP-positive regulation of cellular glucuronidation18556656
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PRKCEACTA111156711897493 Affinity Capture-MS; Affinity Capture-Western
PRKCEACTA110657311897493 Affinity Capture-MS; Affinity Capture-Western
PRKCESLC25A411156712663490 Affinity Capture-Western
PRKCESLC25A410678812663490 Affinity Capture-Western
PRKCECFTR11156711956211 Affinity Capture-Western
PRKCECFTR10750611956211 Affinity Capture-Western
PRKCEDSP11156720936779 Two-hybrid
PRKCEDSP10816620936779 Two-hybrid
PRKCEGAD111156715147202 Biochemical Activity
PRKCEGAD110884515147202 Biochemical Activity
PRKCEGAD211156715147202 Biochemical Activity
PRKCEGAD210884615147202 Biochemical Activity
PRKCEGJA111156710679481 Affinity Capture-Western
PRKCEGJA110896410679481 Affinity Capture-Western
PRKCEGNA121115678824244 Biochemical Activity
PRKCEGNA121090308824244 Biochemical Activity
PRKCEHK211156712663490 Affinity Capture-Western
PRKCEHK210934612663490 Affinity Capture-Western
PRKCEKRT111004611897493 Affinity Capture-MS; Affinity Capture-Western
PRKCEKRT111156711897493 Affinity Capture-MS; Affinity Capture-Western
PRKCEKRT81100541374067 Affinity Capture-Western
PRKCEKRT81115671374067 Affinity Capture-Western
PRKCEKRT181100731374067 Affinity Capture-Western
PRKCEKRT181115671374067 Affinity Capture-Western
PRKCEMYH911156711897493 Affinity Capture-MS; Affinity Capture-Western
PRKCEMYH911071211897493 Affinity Capture-MS; Affinity Capture-Western
PRKCEPIK3CB1113099822674 Affinity Capture-Western
PRKCEPIK3CB1115679822674 Affinity Capture-Western
GNA13PRKCE1159148824244 Biochemical Activity
GNA13PRKCE1115678824244 Biochemical Activity
PDLIM5PRKCE1158578940095 Two-hybrid
PDLIM5PRKCE1115678940095 Two-hybrid
TIAM1PRKCE11156710212259 Biochemical Activity
TIAM1PRKCE11293010212259 Biochemical Activity
MAPK1PRKCE11156711350735 Affinity Capture-Western
MAPK1PRKCE11158011350735 Affinity Capture-Western
RAF1PRKCE11183111350735 Affinity Capture-Western
RAF1PRKCE11156711350735 Affinity Capture-Western
COPB2PRKCE11469311897493 Affinity Capture-MS; Affinity Capture-Western
COPB2PRKCE11156711897493 Affinity Capture-MS; Affinity Capture-Western
YWHAZPRKCE11336611950841 Affinity Capture-Western
YWHAZPRKCE11156711950841 Affinity Capture-Western
GNB2L1PRKCE11156711956211 Affinity Capture-Western; Far Western; Reconstituted Complex
GNB2L1PRKCE11567111956211 Affinity Capture-Western; Far Western; Reconstituted Complex
AFAP1PRKCE12189512134071 Reconstituted Complex
AFAP1PRKCE11156712134071 Reconstituted Complex
VDAC1PRKCE11156712663490 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
VDAC1PRKCE11325912663490 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
ADAP1PRKCE11622212893243 Biochemical Activity
ADAP1PRKCE11156712893243 Biochemical Activity
RASGRP3PRKCE11731515213298 Biochemical Activity
RASGRP3PRKCE11156715213298 Biochemical Activity
MAP4K4PRKCE11483820936779 Two-hybrid
MAP4K4PRKCE11156720936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
PRKCEPDPK126239112223477 An unspecified isoform of PDPK1 (PDK1) phosphorylates PRKCE (PKC-epsilon). This interaction was modeled on a demonstrated interaction between PDPK1 from an unspecified species and PRKCE from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97599
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-8191'