AutismKB 2.0

Annotation Details for PRKCH


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Basic Information Top
Gene Symbol:PRKCH ( MGC26269,MGC5363,PKC-L,PKCL,PRKCL,nPKC-eta )
Gene Full Name: protein kinase C, eta
Band: 14q23.1
Quick LinksEntrez ID:5583; OMIM: 605437; Uniprot ID:KPCL_HUMAN; ENSEMBL ID: ENSG00000027075; HGNC ID: 9403
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm15632189
GO:0005829ISS-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane15632189
GO:0005911IEA-cell-cell junction-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0004697TAS-protein kinase C activity1986216
GO:0004699IEA-calcium-independent protein kinase C activity-
GO:0005524IEA-ATP binding-
GO:0017160IEA-Ral GTPase binding-
GO:0019899IPI-enzyme binding15632189
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0006468IMP-protein phosphorylation22304920
GO:0007165TAS-signal transduction1986216
GO:0010744ISS-positive regulation of macrophage derived foam cell differentiation-
GO:0018105IBA-peptidyl-serine phosphorylation-
GO:0030168TAS-platelet activation-
GO:0034351IMP-negative regulation of glial cell apoptotic process11772428
GO:0035556IBA-intracellular signal transduction-
GO:0045618ISS-positive regulation of keratinocyte differentiation-
GO:0050861IMP-positive regulation of B cell receptor signaling pathway18780722
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity21820409
GO:0060252IMP-positive regulation of glial cell proliferation10806212
GO:0070528IEA-protein kinase C signaling-
GO:1903078TAS-positive regulation of protein localization to plasma membrane22732145
GO:2000810IMP-regulation of bicellular tight junction assembly19114660
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PRKCHCDK211156911175348 Affinity Capture-Western
PRKCHCDK210745211175348 Affinity Capture-Western
PRKCHMGMT11156916226712 Affinity Capture-MS
PRKCHMGMT11041116226712 Affinity Capture-MS
ZBTB8OSPRKCH13089320936779 Two-hybrid
ZBTB8OSPRKCH11156920936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
PRKCHPDPK126238912223477 An unspecified isoform of PDPK1 (PDK1) interacts with and phosphorylates PRKCH (PKC-eta). This interaction was modeled on a demonstrated interaction between PDPK1 from an unspecified species and PRKCH from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97600
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041001-104'