AutismKB 2.0

Annotation Details for PKN1


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Basic Information Top
Gene Symbol:PKN1 ( DBK,MGC46204,PAK-1,PAK1,PKN,PKN-ALPHA,PRK1,PRKCL1 )
Gene Full Name: protein kinase N1
Band: 19p13.12
Quick LinksEntrez ID:5585; OMIM: 601032; Uniprot ID:PKN1_HUMAN; ENSEMBL ID: ENSG00000123143; HGNC ID: 9405
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus12514133
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm12514133
GO:0005768IDA-endosome9478917
GO:0005829TAS-cytosol-
GO:0005886IEA-plasma membrane-
GO:0030496IDA-midbody17332740
GO:0032154IDA-cleavage furrow17332740
GO:0043234IEA-protein complex-
GO ID Evidence Qualifier GO_term References
GO:0003682IDA-chromatin binding18066052
GO:0004672TAS-protein kinase activity8135837
GO:0004674EXP-protein serine/threonine kinase activity18066052
GO:0004674IDA-protein serine/threonine kinase activity20188095
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004697IEA-protein kinase C activity-
GO:0005080IPI-protein kinase C binding20228790
GO:0005515IPI-protein binding12761180
GO:0005524IEA-ATP binding-
GO:0017049IDA-GTP-Rho binding9478917
GO:0030374IDA-ligand-dependent nuclear receptor transcription coactivator activity12514133
GO:0030374IMP-ligand-dependent nuclear receptor transcription coactivator activity18066052
GO:0035402IDA-histone kinase activity (H3-T11 specific)18066052
GO:0042393IDA-histone binding18066052
GO:0042826IDA-histone deacetylase binding20188095
GO:0048365IDA-Rac GTPase binding18006505
GO:0050681IDA-androgen receptor binding12514133
GO ID Evidence Qualifier GO_term References
GO:0001782IEA-B cell homeostasis-
GO:0001783IEA-B cell apoptotic process-
GO:0002634IEA-regulation of germinal center formation-
GO:0002637IEA-regulation of immunoglobulin production-
GO:0003014IEA-renal system process-
GO:0006351IEA-transcription, DNA-templated-
GO:0006357IDA-regulation of transcription from RNA polymerase II promoter12514133
GO:0006357IMP-regulation of transcription from RNA polymerase II promoter18066052
GO:0006468IDA-protein phosphorylation17332740
GO:0006469IEA-negative regulation of protein kinase activity-
GO:0006972IEA-hyperosmotic response-
GO:0007165TAS-signal transduction8135837
GO:0007257TAS-activation of JUN kinase activity8805275
GO:0010631IMP-epithelial cell migration21754995
GO:0018105IBA-peptidyl-serine phosphorylation-
GO:0030889IEA-negative regulation of B cell proliferation-
GO:0035407IDA-histone H3-T11 phosphorylation18066052
GO:0048536IEA-spleen development-
GO:2000145IMP-regulation of cell motility21754995
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PKN1ACTN111157111802708 Affinity Capture-Western
PKN1ACTN110660211802708 Affinity Capture-Western
PKN1RHOA1068809446575 9535835 12773565 Far Western; Reconstituted Complex; Two-hybrid
PKN1RHOA1115719446575 9535835 12773565 Far Western; Reconstituted Complex; Two-hybrid
PKN1CDR21115719637778 Two-hybrid
PKN1CDR21074709637778 Two-hybrid
PKN1NEFH1108198621664 Reconstituted Complex; Two-hybrid
PKN1NEFH1115718621664 Reconstituted Complex; Two-hybrid
PKN1NEFL1115718621664 Reconstituted Complex; Two-hybrid
PKN1NEFL1108228621664 Reconstituted Complex; Two-hybrid
PKN1NEUROD211083410640683 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PKN1NEUROD211157110640683 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PKN1PDK111118910753910 Affinity Capture-Western
PKN1PDK111157110753910 Affinity Capture-Western
PKN1PDPK111119610764742 Reconstituted Complex; Two-hybrid
PKN1PDPK111157110764742 Reconstituted Complex; Two-hybrid
PKN1PLD111157111259428 Affinity Capture-Western; Reconstituted Complex
PKN1PLD111135311259428 Affinity Capture-Western; Reconstituted Complex
VIMPKN11115719175763 Biochemical Activity; Two-hybrid
VIMPKN11132729175763 Biochemical Activity; Two-hybrid
AKAP9PKN111157110358086 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AKAP9PKN111544510358086 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CCDC85BPKN111157116189514 Affinity Capture-Western; Two-hybrid
CCDC85BPKN111619816189514 Affinity Capture-Western; Two-hybrid
HIST2H3CPKN111157118066052 Biochemical Activity
HIST2H3CPKN112602518066052 Biochemical Activity
HDAC6PKN111157119036992 Affinity Capture-Western; Reconstituted Complex
HDAC6PKN111533019036992 Affinity Capture-Western; Reconstituted Complex
HDAC5PKN111157120188095 Biochemical Activity
HDAC5PKN111533120188095 Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:108022
  • Data Attributes: MGI curated and HomoloGene calculated
No data