AutismKB 2.0

Annotation Details for PRKD1


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Basic Information Top
Gene Symbol:PRKD1 ( PKC-MU,PKCM,PKD,PRKCM )
Gene Full Name: protein kinase D1
Band: 14q12
Quick LinksEntrez ID:5587; OMIM: 605435; Uniprot ID:KPCD1_HUMAN; ENSEMBL ID: ENSG00000184304; HGNC ID: 9407
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000421IDA-autophagosome membrane22095288
GO:0005794IDA-Golgi apparatus11239398
GO:0005802IDA-trans-Golgi network19211839
GO:0005829IDA-cytosol-
GO:0005829ISS-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane-
GO:0005887TAS-integral component of plasma membrane8119958
GO ID Evidence Qualifier GO_term References
GO:0004674IDA-protein serine/threonine kinase activity18440775
GO:0004674TAS-protein serine/threonine kinase activity8119958
GO:0004697IDA-protein kinase C activity12637538
GO:0005515IPI-protein binding10831594
GO:0005524IEA-ATP binding-
GO:0016301IDA-kinase activity24623306
GO:0042802IPI-identical protein binding10831594
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0001938IGI-positive regulation of endothelial cell proliferation20497126
GO:0006468IDA-protein phosphorylation24623306
GO:0006915IEA-apoptotic process-
GO:0006954IEA-inflammatory response-
GO:0007030IMP-Golgi organization19211839
GO:0007165TAS-signal transduction8119958
GO:0007229TAS-integrin-mediated signaling pathway21488147
GO:0007265IMP-Ras protein signal transduction24623306
GO:0008283TAS-cell proliferation8119958
GO:0010508IMP-positive regulation of autophagy22095288
GO:0010595IMP-positive regulation of endothelial cell migration18332134
GO:0010837ISS-regulation of keratinocyte proliferation-
GO:0010976IMP-positive regulation of neuron projection development19211839
GO:0018105IDA-peptidyl-serine phosphorylation18440775
GO:0018107IDA-peptidyl-threonine phosphorylation22095288
GO:0030148TAS-sphingolipid biosynthetic process-
GO:0031647IMP-regulation of protein stability24623306
GO:0032793IGI-positive regulation of CREB transcription factor activity20497126
GO:0033138IGI-positive regulation of peptidyl-serine phosphorylation20497126
GO:0034198IMP-cellular response to amino acid starvation22095288
GO:0034599IDA-cellular response to oxidative stress12505989
GO:0035556IMP-intracellular signal transduction18059339
GO:0035924IGI-cellular response to vascular endothelial growth factor stimulus20497126
GO:0035924IMP-cellular response to vascular endothelial growth factor stimulus18059339
GO:0038033IGI-positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway20497126
GO:0038033IMP-positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway18440775
GO:0043123IMP-positive regulation of I-kappaB kinase/NF-kappaB signaling12505989
GO:0043536IGI-positive regulation of blood vessel endothelial cell migration20497126
GO:0043536IMP-positive regulation of blood vessel endothelial cell migration18440775
GO:0043552IC-positive regulation of phosphatidylinositol 3-kinase activity22095288
GO:0045087IEA-innate immune response-
GO:0045669ISS-positive regulation of osteoblast differentiation-
GO:0045766IGI-positive regulation of angiogenesis20497126
GO:0045766IMP-positive regulation of angiogenesis18332134
GO:0045806TAS-negative regulation of endocytosis21488147
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter18059339
GO:0046777IDA-protein autophosphorylation24623306
GO:0046777TAS-protein autophosphorylation21488147
GO:0048010IMP-vascular endothelial growth factor receptor signaling pathway18059339
GO:0048193ISS-Golgi vesicle transport-
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity12505989
GO:0060548IMP-negative regulation of cell death12505989
GO:0071447IMP-cellular response to hydroperoxide22095288
GO:0089700IGI-protein kinase D signaling20497126
GO:1901727IGI-positive regulation of histone deacetylase activity20497126
GO:2001028IMP-positive regulation of endothelial cell chemotaxis18440775
GO:2001044TAS-regulation of integrin-mediated signaling pathway21488147
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PRKD1BTK10716010561498 Affinity Capture-Western; Reconstituted Complex
PRKD1BTK11157310561498 Affinity Capture-Western; Reconstituted Complex
PRKD1C1QBP11157310831594 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PRKD1C1QBP10716910831594 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PRKD1HSPB110954715728188 Biochemical Activity; Reconstituted Complex
PRKD1HSPB111157315728188 Biochemical Activity; Reconstituted Complex
PRKD1JUN10992811948398 Biochemical Activity
PRKD1JUN11157311948398 Biochemical Activity
PRKD1MT2A11157314550308 Affinity Capture-Western; Two-hybrid
PRKD1MT2A11060814550308 Affinity Capture-Western; Two-hybrid
PRKD1PLCG11115738885868 Affinity Capture-Western
PRKD1PLCG11113518885868 Affinity Capture-Western
PRKD1PLCG21115738885868 Affinity Capture-Western
PRKD1PLCG21113528885868 Affinity Capture-Western
SYKPRKD11115738885868 Affinity Capture-Western
SYKPRKD11127178885868 Affinity Capture-Western
YWHAQPRKD111616810092600 10831594 Affinity Capture-Western; Reconstituted Complex
YWHAQPRKD111157310092600 10831594 Affinity Capture-Western; Reconstituted Complex
MAPK8PRKD111158511948398 Affinity Capture-Western
MAPK8PRKD111157311948398 Affinity Capture-Western
MAPK9PRKD111157311948398 Affinity Capture-Western
MAPK9PRKD111158711948398 Affinity Capture-Western
ADAP1PRKD111622212893243 Biochemical Activity; Reconstituted Complex
ADAP1PRKD111157312893243 Biochemical Activity; Reconstituted Complex
YWHAZPRKD111336612893243 Reconstituted Complex
YWHAZPRKD111157312893243 Reconstituted Complex
HDAC5PRKD111533115367659 15728188 Affinity Capture-Western
HDAC5PRKD111157315367659 15728188 Affinity Capture-Western
HDAC7PRKD111157319029091 Affinity Capture-Western
HDAC7PRKD111961319029091 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99879
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-080131-1'