AutismKB 2.0

Annotation Details for ERBB2IP


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Basic Information Top
Gene Symbol:ERBB2IP ( ERBIN,LAP2 )
Gene Full Name: erbb2 interacting protein
Band: 5q12.3
Quick LinksEntrez ID:55914; OMIM: 606944; Uniprot ID:LAP2_HUMAN; ENSEMBL ID: ENSG00000112851; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005604TAS-basement membrane10878805
GO:0005634IDA-nucleus11375975
GO:0005737IDA-cytoplasm11375975
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0009925NAS-basal plasma membrane11375975
GO:0016323IDA-basolateral plasma membrane16203728
GO:0016607IDA-nuclear speck-
GO:0030054IDA-cell junction-
GO:0030056IDA-hemidesmosome11375975
GO:0031965IEA-nuclear membrane-
GO ID Evidence Qualifier GO_term References
GO:0005102IPI-receptor binding16203728
GO:0005176TAS-ErbB-2 class receptor binding11375975
GO:0005178IPI-integrin binding11375975
GO:0005200NAS-structural constituent of cytoskeleton11375975
GO:0005515IPI-protein binding11375975
GO ID Evidence Qualifier GO_term References
GO:0006605IEA-protein targeting-
GO:0007049NAS-cell cycle11375975
GO:0007155NAS-cell adhesion11375975
GO:0007165TAS-signal transduction10878805
GO:0007173TAS-epidermal growth factor receptor signaling pathway11375975
GO:0007229NAS-integrin-mediated signaling pathway11375975
GO:0016049NAS-cell growth11375975
GO:0032088IMP-negative regulation of NF-kappaB transcription factor activity16203728
GO:0032495IMP-response to muramyl dipeptide16203728
GO:0032496IMP-response to lipopolysaccharide16203728
GO:0038128TAS-ERBB2 signaling pathway-
GO:0045104NAS-intermediate filament cytoskeleton organization11375975
GO:0045175NAS-basal protein localization11375975
GO:0045197NAS-establishment or maintenance of epithelial cell apical/basal polarity11375975
GO:0070433IMP-negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway16203728
GO:0071356IMP-cellular response to tumor necrosis factor16203728
GO:0071638IEA-negative regulation of monocyte chemotactic protein-1 production-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ERBB2IPAPC12099720936779 Two-hybrid
ERBB2IPAPC10682120936779 Two-hybrid
ERBB2IPARVCF12099711821434 Reconstituted Complex
ERBB2IPARVCF10691411821434 Reconstituted Complex
ERBB2IPDST12099711375975 Reconstituted Complex; Two-hybrid
ERBB2IPDST10713511375975 Reconstituted Complex; Two-hybrid
ERBB2IPCTNND112099711821434 Reconstituted Complex
ERBB2IPCTNND110788111821434 Reconstituted Complex
ERBB2IPERBB212099710878805 11278603 12379659 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ERBB2IPERBB210837610878805 11278603 12379659 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ERBB2IPGRIN2B12099711278603 Reconstituted Complex
ERBB2IPGRIN2B10916111278603 Reconstituted Complex
ERBB2IPGRIN2C12099711278603 Reconstituted Complex
ERBB2IPGRIN2C10916211278603 Reconstituted Complex
ERBB2IPHRAS10950112379659 Affinity Capture-Western
ERBB2IPHRAS12099712379659 Affinity Capture-Western
ERBB2IPITGB412099711375975 Reconstituted Complex; Two-hybrid
ERBB2IPITGB410989711375975 Reconstituted Complex; Two-hybrid
ERBB2IPKCNA410994211278603 Reconstituted Complex
ERBB2IPKCNA412099711278603 Reconstituted Complex
ERBB2IPSMAD111026112650946 Reconstituted Complex
ERBB2IPSMAD112099712650946 Reconstituted Complex
ERBB2IPSMAD212099712650946 18003620 Affinity Capture-MS; Reconstituted Complex
ERBB2IPSMAD211026212650946 18003620 Affinity Capture-MS; Reconstituted Complex
ERBB2IPSMAD312099712650946 18003620 Affinity Capture-MS; Reconstituted Complex; Two-hybrid
ERBB2IPSMAD311026312650946 18003620 Affinity Capture-MS; Reconstituted Complex; Two-hybrid
ERBB2IPSMAD412099712650946 Reconstituted Complex
ERBB2IPSMAD411026412650946 Reconstituted Complex
ERBB2IPSMAD712099712650946 Reconstituted Complex
ERBB2IPSMAD711026712650946 Reconstituted Complex
ERBB2IPPKP412099711711544 11821434 12047349 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ERBB2IPPKP411407411711544 11821434 12047349 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ERBB2IPPICK112099711278603 Two-hybrid
ERBB2IPPICK111484911278603 Two-hybrid
ERBB2IPPDZD212099712370826 Affinity Capture-Western
ERBB2IPPDZD211667612370826 Affinity Capture-Western
ERBB2IPRPAP112099717643375 Affinity Capture-MS
ERBB2IPRPAP111748717643375 Affinity Capture-MS
ERBB2IPLRRC112099711440998 Reconstituted Complex
ERBB2IPLRRC112052211440998 Reconstituted Complex
ERBB2IPERBB2IP12099711278603 Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1890169
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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