AutismKB 2.0

Annotation Details for MAPK3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MAPK3 ( ERK1,HS44KDAP,HUMKER1A,MGC20180,P44ERK1,P44MAPK,PRKM3 )
Gene Full Name: mitogen-activated protein kinase 3
Band: 16p11.2
Quick LinksEntrez ID:5595; OMIM: 601795; Uniprot ID:MK03_HUMAN; ENSEMBL ID: ENSG00000102882; HGNC ID: 6877
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634TAS-nucleus19565474
GO:0005635IDA-nuclear envelope20455999
GO:0005654TAS-nucleoplasm-
GO:0005739TAS-mitochondrion19565474
GO:0005769TAS-early endosome19565474
GO:0005770TAS-late endosome19565474
GO:0005794TAS-Golgi apparatus19565474
GO:0005829TAS-cytosol19565474
GO:0005856TAS-cytoskeleton19565474
GO:0005901TAS-caveola19565474
GO:0005925TAS-focal adhesion19565474
GO:0031143IEA-pseudopodium-
GO:0043234IEA-protein complex-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0001784IEA-phosphotyrosine residue binding-
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004707IDA-MAP kinase activity8388392
GO:0004707NAS-MAP kinase activity7687743
GO:0004707TAS-MAP kinase activity-
GO:0005515IPI-protein binding10066421
GO:0005524IEA-ATP binding-
GO:0016301TAS-kinase activity-
GO:0019902IPI-phosphatase binding19494114
GO:0097110IEA-scaffold protein binding-
GO ID Evidence Qualifier GO_term References
GO:0000165NAS-MAPK cascade20018936
GO:0000165TAS-MAPK cascade-
GO:0000187TAS-activation of MAPK activity-
GO:0000189IEA-MAPK import into nucleus-
GO:0001934IMP-positive regulation of protein phosphorylation19664780
GO:0002741IEA-positive regulation of cytokine secretion involved in immune response-
GO:0006361TAS-transcription initiation from RNA polymerase I promoter-
GO:0006461IEA-protein complex assembly-
GO:0006468IDA-protein phosphorylation7687743
GO:0006915IEA-apoptotic process-
GO:0006975IDA-DNA damage induced protein phosphorylation17560175
GO:0007049IEA-cell cycle-
GO:0007411TAS-axon guidance-
GO:0008543TAS-fibroblast growth factor receptor signaling pathway-
GO:0009636IEA-response to toxic substance-
GO:0010628IMP-positive regulation of gene expression24136195
GO:0010759IEA-positive regulation of macrophage chemotaxis-
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0016032IEA-viral process-
GO:0016310IDA-phosphorylation15950189
GO:0018105IEA-peptidyl-serine phosphorylation-
GO:0019233IEA-sensory perception of pain-
GO:0019369IEA-arachidonic acid metabolic process-
GO:0030168TAS-platelet activation-
GO:0030278IEA-regulation of ossification-
GO:0030509IMP-BMP signaling pathway19664780
GO:0030878IEA-thyroid gland development-
GO:0031281IMP-positive regulation of cyclase activity22027397
GO:0031663IEA-lipopolysaccharide-mediated signaling pathway-
GO:0032212IMP-positive regulation of telomere maintenance via telomerase21531765
GO:0032872TAS-regulation of stress-activated MAPK cascade19565474
GO:0033129IMP-positive regulation of histone phosphorylation20018936
GO:0034198IDA-cellular response to amino acid starvation11096076
GO:0034614IMP-cellular response to reactive oxygen species26514923
GO:0035066IMP-positive regulation of histone acetylation20018936
GO:0038083IDA-peptidyl-tyrosine autophosphorylation8388392
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0042473IEA-outer ear morphogenesis-
GO:0043330IEA-response to exogenous dsRNA-
GO:0045727IEA-positive regulation of translation-
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter20018936
GO:0048538IEA-thymus development-
GO:0051090TAS-regulation of sequence-specific DNA binding transcription factor activity-
GO:0051216IEA-cartilage development-
GO:0051403IDA-stress-activated MAPK cascade11096076
GO:0051493TAS-regulation of cytoskeleton organization19565474
GO:0051973IMP-positive regulation of telomerase activity21531765
GO:0060020IEA-Bergmann glial cell differentiation-
GO:0060324IEA-face development-
GO:0060397TAS-JAK-STAT cascade involved in growth hormone signaling pathway-
GO:0060425IEA-lung morphogenesis-
GO:0060440IEA-trachea formation-
GO:0061308IEA-cardiac neural crest cell development involved in heart development-
GO:0070371IEA-ERK1 and ERK2 cascade-
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade19664780
GO:0070498IMP-interleukin-1-mediated signaling pathway20018936
GO:0070849IDA-response to epidermal growth factor18794356
GO:0071260IEP-cellular response to mechanical stimulus19593445
GO:0071276IMP-cellular response to cadmium ion26514923
GO:0072584TAS-caveolin-mediated endocytosis19565474
GO:0090170TAS-regulation of Golgi inheritance19565474
GO:1900034TAS-regulation of cellular response to heat-
GO:1903351IMP-cellular response to dopamine24136195
GO:1904355IMP-positive regulation of telomere capping21531765
GO:1904417IEA-positive regulation of xenophagy-
GO:1905050IEA-positive regulation of metallopeptidase activity-
GO:2000641TAS-regulation of early endosome to late endosome transport19565474
GO:2000657IEA-negative regulation of apolipoprotein binding-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAPK3ARRB211158112473660 Affinity Capture-Western
MAPK3ARRB210690212473660 Affinity Capture-Western
MAPK3ATP1A111158115069082 Biochemical Activity
MAPK3ATP1A110696615069082 Biochemical Activity
MAPK3AVPR211158112473660 Affinity Capture-Western
MAPK3AVPR210703512473660 Affinity Capture-Western
MAPK3BRAF11158110869359 Phenotypic Enhancement
MAPK3BRAF10714110869359 Phenotypic Enhancement
MAPK3C1QBP11158111866440 Biochemical Activity
MAPK3C1QBP10716911866440 Biochemical Activity
MAPK3CDC25C11158116582626 Affinity Capture-Western; Reconstituted Complex
MAPK3CDC25C10743016582626 Affinity Capture-Western; Reconstituted Complex
MAPK3MAPK1411158112697810 Affinity Capture-Western
MAPK3MAPK1410781912697810 Affinity Capture-Western
MAPK3DCC11158111986622 Two-hybrid
MAPK3DCC10799811986622 Two-hybrid
MAPK3DUSP110817611278799 Two-hybrid
MAPK3DUSP111158111278799 Two-hybrid
MAPK3DUSP310817810224087 Affinity Capture-Western; Biochemical Activity
MAPK3DUSP311158110224087 Affinity Capture-Western; Biochemical Activity
MAPK3DUSP410817911387337 Reconstituted Complex
MAPK3DUSP411158111387337 Reconstituted Complex
MAPK3DUSP51081807836374 Biochemical Activity
MAPK3DUSP51115817836374 Biochemical Activity
MAPK3DUSP61081819535927 Affinity Capture-Western; Reconstituted Complex
MAPK3DUSP61115819535927 Affinity Capture-Western; Reconstituted Complex
MAPK3ETV111158111551945 Biochemical Activity
MAPK3ETV110841611551945 Biochemical Activity
MAPK3GMFB1115818639570 Affinity Capture-Western
MAPK3GMFB1090268639570 Affinity Capture-Western
MAPK3GTF2I11158110648599 Affinity Capture-Western; Biochemical Activity
MAPK3GTF2I10922410648599 Affinity Capture-Western; Biochemical Activity
MAPK3INSR11158111409918 Affinity Capture-Western
MAPK3INSR10985411409918 Affinity Capture-Western
MAPK3JUN1099281922387 Biochemical Activity
MAPK3JUN1115811922387 Biochemical Activity
MAPK3LYN11024511131153 Affinity Capture-Western
MAPK3LYN11158111131153 Affinity Capture-Western
MAPK3CIITA11158118245089 Affinity Capture-Western
MAPK3CIITA11041618245089 Affinity Capture-Western
MAPK3MYC11158115210690 Reconstituted Complex
MAPK3MYC11069415210690 Reconstituted Complex
THMAPK31129121347949 Biochemical Activity
THMAPK31115811347949 Biochemical Activity
MAP2K1MAPK31115818226933 8626767 9006895 9733512 10748187 Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
MAP2K1MAPK31115908226933 8626767 9006895 9733512 10748187 Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
MAP2K2MAPK31115818226933 8626767 9006895 Biochemical Activity; Reconstituted Complex; Two-hybrid
MAP2K2MAPK31115918226933 8626767 9006895 Biochemical Activity; Reconstituted Complex; Two-hybrid
MAP2K3MAPK31115818226933 Reconstituted Complex
MAP2K3MAPK31115928226933 Reconstituted Complex
SPIBMAPK31115818632909 Biochemical Activity; Co-purification
SPIBMAPK31125678632909 Biochemical Activity; Co-purification
RPS6KA2MAPK31115818939914 12832467 Affinity Capture-Western
RPS6KA2MAPK31121108939914 12832467 Affinity Capture-Western
RPS6KA3MAPK31115818939914 Affinity Capture-Western
RPS6KA3MAPK31121118939914 Affinity Capture-Western
MKNK1MAPK31141389155018 Biochemical Activity
MKNK1MAPK31115819155018 Biochemical Activity
MAPKSP1MAPK31142019733512 Affinity Capture-Western
MAPKSP1MAPK31115819733512 Affinity Capture-Western
RPS6KA4MAPK31144689792677 Affinity Capture-Western
RPS6KA4MAPK31115819792677 Affinity Capture-Western
PTPRRMAPK31115819857190 Reconstituted Complex
PTPRRMAPK31117659857190 Reconstituted Complex
PTPN5MAPK31243129857190 Reconstituted Complex
PTPN5MAPK31115819857190 Reconstituted Complex
PTPN7MAPK311174310206983 10559944 10702794 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PTPN7MAPK311158110206983 10559944 10702794 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SREBF1MAPK311259810627507 Biochemical Activity
SREBF1MAPK311158110627507 Biochemical Activity
SREBF2MAPK311259910627507 Biochemical Activity
SREBF2MAPK311158110627507 Biochemical Activity
TP53MAPK311301010958792 Affinity Capture-Western
TP53MAPK311158110958792 Affinity Capture-Western
HDAC4MAPK311158111114188 Affinity Capture-Western; Biochemical Activity
HDAC4MAPK311510611114188 Affinity Capture-Western; Biochemical Activity
RAF1MAPK311183111409918 Affinity Capture-Western
RAF1MAPK311158111409918 Affinity Capture-Western
PEA15MAPK311423011702783 Two-hybrid
PEA15MAPK311158111702783 Two-hybrid
SNCAMAPK311250612121974 Affinity Capture-Western
SNCAMAPK311158112121974 Affinity Capture-Western
SNCGMAPK311158112121974 Affinity Capture-Western
SNCGMAPK311250712121974 Affinity Capture-Western
IER3MAPK311439012356731 Affinity Capture-Western
IER3MAPK311158112356731 Affinity Capture-Western
UBR5MAPK311950112594221 Affinity Capture-Western
UBR5MAPK311158112594221 Affinity Capture-Western
RPS6KA1MAPK311158112832467 Affinity Capture-Western
RPS6KA1MAPK311210912832467 Affinity Capture-Western
BAZ1BMAPK311449719776015 Biochemical Activity
BAZ1BMAPK311158119776015 Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346859
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040121-1'