AutismKB 2.0

Annotation Details for MAPK8


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MAPK8 ( JNK,JNK1,JNK1A2,JNK21B1/2,PRKM8,SAPK1 )
Gene Full Name: mitogen-activated protein kinase 8
Band: 10q11.22
Quick LinksEntrez ID:5599; OMIM: 601158; Uniprot ID:MK08_HUMAN; ENSEMBL ID: ENSG00000107643; HGNC ID: 6881
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus20027304
GO:0005654TAS-nucleoplasm-
GO:0005737IBA-cytoplasm-
GO:0005739IEA-mitochondrion-
GO:0005829TAS-cytosol-
GO:0043005IBA-neuron projection-
GO ID Evidence Qualifier GO_term References
GO:0004674IDA-protein serine/threonine kinase activity14967141
GO:0004705IDA-JUN kinase activity8654373
GO:0004705TAS-JUN kinase activity-
GO:0005515IPI-protein binding10393177
GO:0005524IEA-ATP binding-
GO:0016301TAS-kinase activity-
GO:0019899IPI-enzyme binding14615289
GO:0035033IMP-histone deacetylase regulator activity20027304
GO:0042826IPI-histone deacetylase binding20027304
GO ID Evidence Qualifier GO_term References
GO:0006468IDA-protein phosphorylation21856198
GO:0006468IMP-protein phosphorylation22441692
GO:0006950TAS-response to stress8137421
GO:0007254IDA-JNK cascade8654373
GO:0007254TAS-JNK cascade-
GO:0007258IDA-JUN phosphorylation14967141
GO:0009411IDA-response to UV14967141
GO:0010628IMP-positive regulation of gene expression22065586
GO:0016241TAS-regulation of macroautophagy26546165
GO:0018105IDA-peptidyl-serine phosphorylation15850461
GO:0018107IDA-peptidyl-threonine phosphorylation21095239
GO:0018107IMP-peptidyl-threonine phosphorylation20027304
GO:0031063IEA-regulation of histone deacetylation-
GO:0031281IMP-positive regulation of cyclase activity22027397
GO:0032091IDA-negative regulation of protein binding21095239
GO:0032880IDA-regulation of protein localization20027304
GO:0034198IDA-cellular response to amino acid starvation11096076
GO:0034614IMP-cellular response to reactive oxygen species26514923
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0042752ISS-regulation of circadian rhythm-
GO:0043065IBA-positive regulation of apoptotic process-
GO:0043065TAS-positive regulation of apoptotic process-
GO:0043066IDA-negative regulation of apoptotic process14967141
GO:0048511IEA-rhythmic process-
GO:0048666IBA-neuron development-
GO:0051090TAS-regulation of sequence-specific DNA binding transcription factor activity-
GO:0051247IMP-positive regulation of protein metabolic process22027397
GO:0051403IDA-stress-activated MAPK cascade11096076
GO:0071222IDA-cellular response to lipopolysaccharide23776175
GO:0071260IEP-cellular response to mechanical stimulus19593445
GO:0071276IMP-cellular response to cadmium ion26514923
GO:0090045IMP-positive regulation of deacetylase activity20027304
GO:1900740TAS-positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-
GO:1902595IMP-regulation of DNA replication origin binding21856198
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAPK8FAS10685115659383 Co-purification
MAPK8FAS11158515659383 Co-purification
MAPK8FASLG11158515659383 Co-purification
MAPK8FASLG10685215659383 Co-purification
MAPK8RHOA10688015659383 Co-purification
MAPK8RHOA11158515659383 Co-purification
MAPK8ARHGDIA10688915659383 Co-purification
MAPK8ARHGDIA11158515659383 Co-purification
MAPK8BID11158515659383 Co-purification
MAPK8BID10710615659383 Co-purification
MAPK8CASP811158515659383 Co-purification
MAPK8CASP810729115659383 Co-purification
MAPK8CASP1011158515659383 Co-purification
MAPK8CASP1010729315659383 Co-purification
MAPK8CDKN1A11158520102411 Affinity Capture-Western
MAPK8CDKN1A10746020102411 Affinity Capture-Western
MAPK8CEBPA11158516983342 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MAPK8CEBPA10747916983342 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MAPK8ATF21115857535770 9207092 9405416 11279118 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MAPK8ATF21077767535770 9207092 9405416 11279118 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MAPK8CRK11158511432831 Affinity Capture-Western; Reconstituted Complex
MAPK8CRK10778811432831 Affinity Capture-Western; Reconstituted Complex
MAPK8DUSP110817611278799 Affinity Capture-Western; Two-hybrid
MAPK8DUSP111158511278799 Affinity Capture-Western; Two-hybrid
MAPK8DUSP410817911387337 Reconstituted Complex
MAPK8DUSP411158511387337 Reconstituted Complex
MAPK8ELK11115858586671 Biochemical Activity
MAPK8ELK11083178586671 Biochemical Activity
MAPK8ETV111158511551945 Biochemical Activity
MAPK8ETV110841611551945 Biochemical Activity
MAPK8GSTP110920511279197 Affinity Capture-Western; Reconstituted Complex
MAPK8GSTP111158511279197 Affinity Capture-Western; Reconstituted Complex
MAPK8H2AFX11158517145805 Reconstituted Complex
MAPK8H2AFX10926817145805 Reconstituted Complex
MAPK8HDAC110931516611996 Affinity Capture-Western
MAPK8HDAC111158516611996 Affinity Capture-Western
MAPK8NR4A111158517023523 Biochemical Activity
MAPK8NR4A110940717023523 Biochemical Activity
MAPK8IRS111158510722755 11606564 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAPK8IRS110987410722755 11606564 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAPK8JUN1099288137421 8586671 8621542 9207092 9774977 11479302 12052834 14633987 16740711 16983342 Biochemical Activity; Reconstituted Complex; Two-hybrid
MAPK8JUN1115858137421 8586671 8621542 9207092 9774977 11479302 12052834 14633987 16740711 16983342 Biochemical Activity; Reconstituted Complex; Two-hybrid
MAPK8JUNB1115859405416 Affinity Capture-Western
MAPK8JUNB1099299405416 Affinity Capture-Western
MAPK8JUND11158512052834 16264271 Affinity Capture-Western; Reconstituted Complex
MAPK8JUND10993012052834 16264271 Affinity Capture-Western; Reconstituted Complex
MAPK8MAP3K11115859405400 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MAPK8MAP3K11103789405400 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MAPK8MSN11158515659383 Co-purification
MAPK8MSN11058415659383 Co-purification
MAPK8MYC11158510551811 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MAPK8MYC11069410551811 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MAPK8NFATC211084615184502 Affinity Capture-Western
MAPK8NFATC211158515184502 Affinity Capture-Western
MAPK8PAX211111011700324 Biochemical Activity
MAPK8PAX211158511700324 Biochemical Activity
MAPK8PDPK111158510357815 Reconstituted Complex
MAPK8PDPK111119610357815 Reconstituted Complex
MAPK8PRKD111158511948398 Affinity Capture-Western
MAPK8PRKD111157311948398 Affinity Capture-Western
MAPK8PRKDC11157711749722 Biochemical Activity
MAPK8PRKDC11158511749722 Biochemical Activity
RELMAPK81118988621542 Affinity Capture-Western; Two-hybrid
RELMAPK81115858621542 Affinity Capture-Western; Two-hybrid
SPI1MAPK81115858632909 Biochemical Activity
SPI1MAPK81125668632909 Biochemical Activity
SPIBMAPK81115858632909 Biochemical Activity; Co-purification
SPIBMAPK81125678632909 Biochemical Activity; Co-purification
MAP2K7MAPK81115859207092 10713157 Affinity Capture-Western; Biochemical Activity; Phenotypic Enhancement
MAP2K7MAPK81115959207092 10713157 Affinity Capture-Western; Biochemical Activity; Phenotypic Enhancement
MAP2K4MAPK81115859207092 10713157 11279118 11707464 12391307 Affinity Capture-Western; Biochemical Activity; Phenotypic Enhancement; Reconstituted Complex
MAP2K4MAPK81123159207092 10713157 11279118 11707464 12391307 Affinity Capture-Western; Biochemical Activity; Phenotypic Enhancement; Reconstituted Complex
TP53MAPK81115859393873 15538975 Affinity Capture-Western; Reconstituted Complex
TP53MAPK81130109393873 15538975 Affinity Capture-Western; Reconstituted Complex
MAPK8IP1MAPK81148649733513 11700324 Affinity Capture-Western
MAPK8IP1MAPK81115859733513 11700324 Affinity Capture-Western
SH2D3AMAPK811158510187783 Phenotypic Enhancement
SH2D3AMAPK811535610187783 Phenotypic Enhancement
DUSP10MAPK811158510391943 Biochemical Activity; Two-hybrid
DUSP10MAPK811638910391943 Biochemical Activity; Two-hybrid
MAPK8IP3MAPK811158510523642 10629060 Biochemical Activity; Reconstituted Complex
MAPK8IP3MAPK811677410523642 10629060 Biochemical Activity; Reconstituted Complex
MAP3K2MAPK811596910713157 Affinity Capture-Western; Co-fractionation
MAP3K2MAPK811158510713157 Affinity Capture-Western; Co-fractionation
DUSP22MAPK812126411346645 Affinity Capture-Western; Biochemical Activity
DUSP22MAPK811158511346645 Affinity Capture-Western; Biochemical Activity
BCAR1MAPK811158511432831 Affinity Capture-Western
BCAR1MAPK811493411432831 Affinity Capture-Western
DUSP16MAPK812332111489891 Affinity Capture-Western
DUSP16MAPK811158511489891 Affinity Capture-Western
IKBKAPMAPK811409012058026 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
IKBKAPMAPK811158512058026 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
SNCAMAPK811250612121974 Affinity Capture-Western
SNCAMAPK811158512121974 Affinity Capture-Western
SNCGMAPK811158512121974 Affinity Capture-Western
SNCGMAPK811250712121974 Affinity Capture-Western
SH3BP5MAPK811158512167088 Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
SH3BP5MAPK811485312167088 Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
SPAG9MAPK811158512391307 Affinity Capture-Western
SPAG9MAPK811450512391307 Affinity Capture-Western
TNFRSF1AMAPK811298615659383 Co-purification
TNFRSF1AMAPK811158515659383 Co-purification
EZRMAPK811158515659383 Co-purification
EZRMAPK811327115659383 Co-purification
FADDMAPK811158515659383 Co-purification
FADDMAPK811430215659383 Co-purification
TNFRSF10BMAPK811158515659383 Co-purification
TNFRSF10BMAPK811432315659383 Co-purification
TFCP2MAPK811158515857981 Biochemical Activity
TFCP2MAPK811288215857981 Biochemical Activity
HDAC9MAPK811158516611996 Affinity Capture-Western; Reconstituted Complex
HDAC9MAPK811508316611996 Affinity Capture-Western; Reconstituted Complex
SIRT1MAPK811698320027304 Affinity Capture-Western; Biochemical Activity
SIRT1MAPK811158520027304 Affinity Capture-Western; Biochemical Activity
Gene Symbol Interactant Interaction ID References Description
MAP2K4MAPK819372012659851 MKK4 phosphorylates JNK1. This interaction was modeled on a demonstrated interaction between MKK4 from an unspecified species and JNK1 from an unpsecified species.
DUSP10MAPK825758110391943 An unspecified isoform of MAPK8 interacts with DUSP10. This interaction was modelled on a demonstrated interaction between MAPK8 from an unspecified species and human DUSP10.
MAP2K7MAPK819371912659851 MKK7 phosphorylates JNK1. This interaction was modeled on a demonstrated interaction between MKK7 from an unspecified species and JNK1 from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346861
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010202-1'