AutismKB 2.0

Annotation Details for MAPK11


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Basic Information Top
Gene Symbol:MAPK11 ( P38B,P38BETA2,PRKM11,SAPK2,SAPK2B,p38-2,p38Beta )
Gene Full Name: mitogen-activated protein kinase 11
Band: 22q13.33
Quick LinksEntrez ID:5600; OMIM: 602898; Uniprot ID:MK11_HUMAN; ENSEMBL ID: ENSG00000185386; HGNC ID: 6873
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0005737IBA-cytoplasm-
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004707IDA-MAP kinase activity8663524
GO:0005515IPI-protein binding17254968
GO:0005524IEA-ATP binding-
GO ID Evidence Qualifier GO_term References
GO:0000165IEA-MAPK cascade-
GO:0000187TAS-activation of MAPK activity-
GO:0006351IEA-transcription, DNA-templated-
GO:0006950IDA-response to stress8663524
GO:0007165TAS-signal transduction8663524
GO:0007265TAS-Ras protein signal transduction-
GO:0010628IMP-positive regulation of gene expression25754930
GO:0035556IDA-intracellular signal transduction8663524
GO:0045648IMPNOTpositive regulation of erythrocyte differentiation23483889
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0051090TAS-regulation of sequence-specific DNA binding transcription factor activity-
GO:0051149TAS-positive regulation of muscle cell differentiation-
GO:0060044IEA-negative regulation of cardiac muscle cell proliferation-
GO:0098586IMP-cellular response to virus25754930
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
GO:2001184IMP-positive regulation of interleukin-12 secretion25754930
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAPK11PML11138415273249 Affinity Capture-Western; Reconstituted Complex
MAPK11PML11158615273249 Affinity Capture-Western; Reconstituted Complex
RPS6KA5MAPK111146769687510 Phenotypic Enhancement
RPS6KA5MAPK111115869687510 Phenotypic Enhancement
HDAC3MAPK1111436815356147 Far Western; Reconstituted Complex; Two-hybrid
HDAC3MAPK1111158615356147 Far Western; Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1338024
  • Data Attributes: MGI curated and HomoloGene calculated
No data