Gene Symbol:	MAP2K1 ( MAPKK1,MEK1,MKK1,PRKMK1 )
Gene Full Name:	mitogen-activated protein kinase kinase 1
Band:	15q22.31
Quick Links	Entrez ID:5604; OMIM: 176872; Uniprot ID:MP2K1_HUMAN; ENSEMBL ID: ENSG00000169032; HGNC ID: 6840
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	TAS	-	nucleus	19565474
GO:0005739	TAS	-	mitochondrion	19565474
GO:0005769	TAS	-	early endosome	19565474
GO:0005770	TAS	-	late endosome	19565474
GO:0005783	IDA	-	endoplasmic reticulum	22572157
GO:0005794	TAS	-	Golgi apparatus	19565474
GO:0005815	IEA	-	microtubule organizing center	-
GO:0005829	IDA	-	cytosol	-
GO:0005829	TAS	-	cytosol	19565474
GO:0005886	IDA	-	plasma membrane	-
GO:0005886	TAS	-	plasma membrane	-
GO:0005925	TAS	-	focal adhesion	19565474
GO:0070062	IDA	-	extracellular exosome	23376485

GO ID	Evidence	Qualifier	GO_term	References
GO:0004672	TAS	-	protein kinase activity	10570282
GO:0004674	TAS	-	protein serine/threonine kinase activity	-
GO:0004702	IBA	-	signal transducer, downstream of receptor, with serine/threonine kinase activity	-
GO:0004708	IDA	-	MAP kinase kinase activity	8388392
GO:0004712	TAS	-	protein serine/threonine/tyrosine kinase activity	19565474
GO:0004713	IEA	-	protein tyrosine kinase activity	-
GO:0004728	IEA	-	signal transducer, downstream of receptor, with protein tyrosine phosphatase activity	-
GO:0005515	IPI	-	protein binding	15299019
GO:0005524	IEA	-	ATP binding	-
GO:0008022	IDA	-	protein C-terminus binding	22572157
GO:0043539	IDA	-	protein serine/threonine kinase activator activity	8388392
GO:0047485	IDA	-	protein N-terminus binding	22572157

GO ID	Evidence	Qualifier	GO_term	References
GO:0000165	TAS	-	MAPK cascade	-
GO:0000187	IDA	-	activation of MAPK activity	10644344
GO:0000187	TAS	-	activation of MAPK activity	19565474
GO:0006928	TAS	-	movement of cell or subcellular component	10912793
GO:0006935	TAS	-	chemotaxis	10570282
GO:0007050	IMP	-	cell cycle arrest	9765203
GO:0007165	TAS	-	signal transduction	10570282
GO:0007507	IEA	-	heart development	-
GO:0008285	IDA	-	negative regulation of cell proliferation	9765203
GO:0010628	IMP	-	positive regulation of gene expression	15155804
GO:0010629	IGI	-	negative regulation of gene expression	23626836
GO:0018108	IEA	-	peptidyl-tyrosine phosphorylation	-
GO:0021697	IEA	-	cerebellar cortex formation	-
GO:0030182	IEA	-	neuron differentiation	-
GO:0030216	IEA	-	keratinocyte differentiation	-
GO:0030878	IEA	-	thyroid gland development	-
GO:0032872	TAS	-	regulation of stress-activated MAPK cascade	19565474
GO:0035897	TAS	-	proteolysis in other organism	-
GO:0045893	IMP	-	positive regulation of transcription, DNA-templated	24375836
GO:0048538	IEA	-	thymus development	-
GO:0048679	IEA	-	regulation of axon regeneration	-
GO:0048870	IEA	-	cell motility	-
GO:0050772	IEA	-	positive regulation of axonogenesis	-
GO:0060020	IEA	-	Bergmann glial cell differentiation	-
GO:0060324	IEA	-	face development	-
GO:0060440	IEA	-	trachea formation	-
GO:0060502	IEA	-	epithelial cell proliferation involved in lung morphogenesis	-
GO:0060674	IEA	-	placenta blood vessel development	-
GO:0060711	IEA	-	labyrinthine layer development	-
GO:0070371	IEA	-	ERK1 and ERK2 cascade	-
GO:0070374	IMP	-	positive regulation of ERK1 and ERK2 cascade	24375836
GO:0071902	IDA	-	positive regulation of protein serine/threonine kinase activity	8388392
GO:0090170	TAS	-	regulation of Golgi inheritance	19565474
GO:0090398	IMP	-	cellular senescence	9765203
GO:1903800	IMP	-	positive regulation of production of miRNAs involved in gene silencing by miRNA	24375836
GO:2000641	TAS	-	regulation of early endosome to late endosome transport	19565474

Gene Symbol	Interactant	Interaction ID	References	Description
MAP2K1	MAP3K8	107719	8631303	Biochemical Activity
MAP2K1	MAP3K8	111590	8631303	Biochemical Activity
MAP2K1	GRB10	109144	9553107	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP2K1	GRB10	111590	9553107	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP2K1	HRAS	109501	7969158	Affinity Capture-Western
MAP2K1	HRAS	111590	7969158	Affinity Capture-Western
MAP2K1	MAP3K1	110378	10969079	Affinity Capture-Western
MAP2K1	MAP3K1	111590	10969079	Affinity Capture-Western
MAP2K1	MAP3K4	110380	9841871	Biochemical Activity
MAP2K1	MAP3K4	111590	9841871	Biochemical Activity
MAP2K1	PEBP1	111076	10757792	Reconstituted Complex
MAP2K1	PEBP1	111590	10757792	Reconstituted Complex
MAP2K1	PLAU	111344	10402467	Phenotypic Suppression
MAP2K1	PLAU	111590	10402467	Phenotypic Suppression
MAP2K1	MAPK1	111580	10757792 11266467 11279118 11352917 11823456 12697810	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
MAP2K1	MAPK1	111590	10757792 11266467 11279118 11352917 11823456 12697810	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
MAP2K1	MAPK3	111581	8226933 8626767 9006895 9733512 10748187	Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
MAP2K1	MAPK3	111590	8226933 8626767 9006895 9733512 10748187	Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
MAP2K1	MAP2K1	111590	8226933	Biochemical Activity
VAV1	MAP2K1	113252	8900182	Affinity Capture-Western
VAV1	MAP2K1	111590	8900182	Affinity Capture-Western
MAPKSP1	MAP2K1	114201	9733512 11266467	Affinity Capture-Western; Two-hybrid
MAPKSP1	MAP2K1	111590	9733512 11266467	Affinity Capture-Western; Two-hybrid
MAPK8IP3	MAP2K1	116774	10523642 11044439	Affinity Capture-Western; Reconstituted Complex
MAPK8IP3	MAP2K1	111590	10523642 11044439	Affinity Capture-Western; Reconstituted Complex
RAF1	MAP2K1	111831	10757792 15485920	Affinity Capture-Western; Reconstituted Complex
RAF1	MAP2K1	111590	10757792 15485920	Affinity Capture-Western; Reconstituted Complex
ROBLD3	MAP2K1	111590	11266467	Affinity Capture-Western
ROBLD3	MAP2K1	118783	11266467	Affinity Capture-Western
KSR2	MAP2K1	129567	12975377	Affinity Capture-Western
KSR2	MAP2K1	111590	12975377	Affinity Capture-Western
PEBP4	MAP2K1	127592	15302887	Affinity Capture-Western; Reconstituted Complex
PEBP4	MAP2K1	111590	15302887	Affinity Capture-Western; Reconstituted Complex
WNK1	MAP2K1	122403	20936779	Two-hybrid
WNK1	MAP2K1	111590	20936779	Two-hybrid

AutismKB 2.0

Annotation Details for MAP2K1