AutismKB 2.0

Annotation Details for MAP2K1


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Basic Information Top
Gene Symbol:MAP2K1 ( MAPKK1,MEK1,MKK1,PRKMK1 )
Gene Full Name: mitogen-activated protein kinase kinase 1
Band: 15q22.31
Quick LinksEntrez ID:5604; OMIM: 176872; Uniprot ID:MP2K1_HUMAN; ENSEMBL ID: ENSG00000169032; HGNC ID: 6840
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634TAS-nucleus19565474
GO:0005739TAS-mitochondrion19565474
GO:0005769TAS-early endosome19565474
GO:0005770TAS-late endosome19565474
GO:0005783IDA-endoplasmic reticulum22572157
GO:0005794TAS-Golgi apparatus19565474
GO:0005815IEA-microtubule organizing center-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol19565474
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005925TAS-focal adhesion19565474
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0004672TAS-protein kinase activity10570282
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004702IBA-signal transducer, downstream of receptor, with serine/threonine kinase activity-
GO:0004708IDA-MAP kinase kinase activity8388392
GO:0004712TAS-protein serine/threonine/tyrosine kinase activity19565474
GO:0004713IEA-protein tyrosine kinase activity-
GO:0004728IEA-signal transducer, downstream of receptor, with protein tyrosine phosphatase activity-
GO:0005515IPI-protein binding15299019
GO:0005524IEA-ATP binding-
GO:0008022IDA-protein C-terminus binding22572157
GO:0043539IDA-protein serine/threonine kinase activator activity8388392
GO:0047485IDA-protein N-terminus binding22572157
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000187IDA-activation of MAPK activity10644344
GO:0000187TAS-activation of MAPK activity19565474
GO:0006928TAS-movement of cell or subcellular component10912793
GO:0006935TAS-chemotaxis10570282
GO:0007050IMP-cell cycle arrest9765203
GO:0007165TAS-signal transduction10570282
GO:0007507IEA-heart development-
GO:0008285IDA-negative regulation of cell proliferation9765203
GO:0010628IMP-positive regulation of gene expression15155804
GO:0010629IGI-negative regulation of gene expression23626836
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0021697IEA-cerebellar cortex formation-
GO:0030182IEA-neuron differentiation-
GO:0030216IEA-keratinocyte differentiation-
GO:0030878IEA-thyroid gland development-
GO:0032872TAS-regulation of stress-activated MAPK cascade19565474
GO:0035897TAS-proteolysis in other organism-
GO:0045893IMP-positive regulation of transcription, DNA-templated24375836
GO:0048538IEA-thymus development-
GO:0048679IEA-regulation of axon regeneration-
GO:0048870IEA-cell motility-
GO:0050772IEA-positive regulation of axonogenesis-
GO:0060020IEA-Bergmann glial cell differentiation-
GO:0060324IEA-face development-
GO:0060440IEA-trachea formation-
GO:0060502IEA-epithelial cell proliferation involved in lung morphogenesis-
GO:0060674IEA-placenta blood vessel development-
GO:0060711IEA-labyrinthine layer development-
GO:0070371IEA-ERK1 and ERK2 cascade-
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade24375836
GO:0071902IDA-positive regulation of protein serine/threonine kinase activity8388392
GO:0090170TAS-regulation of Golgi inheritance19565474
GO:0090398IMP-cellular senescence9765203
GO:1903800IMP-positive regulation of production of miRNAs involved in gene silencing by miRNA24375836
GO:2000641TAS-regulation of early endosome to late endosome transport19565474
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAP2K1MAP3K81077198631303 Biochemical Activity
MAP2K1MAP3K81115908631303 Biochemical Activity
MAP2K1GRB101091449553107 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP2K1GRB101115909553107 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP2K1HRAS1095017969158 Affinity Capture-Western
MAP2K1HRAS1115907969158 Affinity Capture-Western
MAP2K1MAP3K111037810969079 Affinity Capture-Western
MAP2K1MAP3K111159010969079 Affinity Capture-Western
MAP2K1MAP3K41103809841871 Biochemical Activity
MAP2K1MAP3K41115909841871 Biochemical Activity
MAP2K1PEBP111107610757792 Reconstituted Complex
MAP2K1PEBP111159010757792 Reconstituted Complex
MAP2K1PLAU11134410402467 Phenotypic Suppression
MAP2K1PLAU11159010402467 Phenotypic Suppression
MAP2K1MAPK111158010757792 11266467 11279118 11352917 11823456 12697810 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
MAP2K1MAPK111159010757792 11266467 11279118 11352917 11823456 12697810 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
MAP2K1MAPK31115818226933 8626767 9006895 9733512 10748187 Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
MAP2K1MAPK31115908226933 8626767 9006895 9733512 10748187 Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
MAP2K1MAP2K11115908226933 Biochemical Activity
VAV1MAP2K11132528900182 Affinity Capture-Western
VAV1MAP2K11115908900182 Affinity Capture-Western
MAPKSP1MAP2K11142019733512 11266467 Affinity Capture-Western; Two-hybrid
MAPKSP1MAP2K11115909733512 11266467 Affinity Capture-Western; Two-hybrid
MAPK8IP3MAP2K111677410523642 11044439 Affinity Capture-Western; Reconstituted Complex
MAPK8IP3MAP2K111159010523642 11044439 Affinity Capture-Western; Reconstituted Complex
RAF1MAP2K111183110757792 15485920 Affinity Capture-Western; Reconstituted Complex
RAF1MAP2K111159010757792 15485920 Affinity Capture-Western; Reconstituted Complex
ROBLD3MAP2K111159011266467 Affinity Capture-Western
ROBLD3MAP2K111878311266467 Affinity Capture-Western
KSR2MAP2K112956712975377 Affinity Capture-Western
KSR2MAP2K111159012975377 Affinity Capture-Western
PEBP4MAP2K112759215302887 Affinity Capture-Western; Reconstituted Complex
PEBP4MAP2K111159015302887 Affinity Capture-Western; Reconstituted Complex
WNK1MAP2K112240320936779 Two-hybrid
WNK1MAP2K111159020936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346866
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2759'