AutismKB 2.0

Annotation Details for MAP2K2


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Basic Information Top
Gene Symbol:MAP2K2 ( FLJ26075,MAPKK2,MEK2,MKK2,PRKMK2 )
Gene Full Name: mitogen-activated protein kinase kinase 2
Band: 19p13.3
Quick LinksEntrez ID:5605; OMIM: 601263; Uniprot ID:MP2K2_HUMAN; ENSEMBL ID: ENSG00000126934; HGNC ID: 6842
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576NAS-extracellular region8388392
GO:0005634TAS-nucleus19565474
GO:0005739TAS-mitochondrion19565474
GO:0005769TAS-early endosome19565474
GO:0005770TAS-late endosome19565474
GO:0005778IDA-peroxisomal membrane21525035
GO:0005783IDA-endoplasmic reticulum21615688
GO:0005794IDA-Golgi apparatus21615688
GO:0005794TAS-Golgi apparatus19565474
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol19565474
GO:0005874IDA-microtubule21615688
GO:0005886TAS-plasma membrane-
GO:0005911IDA-cell-cell junction21615688
GO:0005925TAS-focal adhesion19565474
GO:0009898IDA-cytoplasmic side of plasma membrane21615688
GO:0048471IDA-perinuclear region of cytoplasm21615688
GO ID Evidence Qualifier GO_term References
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004702IBA-signal transducer, downstream of receptor, with serine/threonine kinase activity-
GO:0004708IDA-MAP kinase kinase activity8388392
GO:0004712TAS-protein serine/threonine/tyrosine kinase activity19565474
GO:0004713IEA-protein tyrosine kinase activity-
GO:0005515IPI-protein binding11909642
GO:0005524IEA-ATP binding-
GO:0030165IDA-PDZ domain binding21615688
GO:0043539IDA-protein serine/threonine kinase activator activity8388392
GO:0046872IEA-metal ion binding-
GO:0097110IPI-scaffold protein binding21615688
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000187TAS-activation of MAPK activity19565474
GO:0010629IGI-negative regulation of gene expression23626836
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0032872TAS-regulation of stress-activated MAPK cascade19565474
GO:0035897TAS-proteolysis in other organism-
GO:0036289IDA-peptidyl-serine autophosphorylation8388392
GO:0045893IMP-positive regulation of transcription, DNA-templated24375836
GO:0070371TAS-ERK1 and ERK2 cascade-
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade24375836
GO:0071902IDA-positive regulation of protein serine/threonine kinase activity8388392
GO:0090170TAS-regulation of Golgi inheritance19565474
GO:1903800IMP-positive regulation of production of miRNAs involved in gene silencing by miRNA24375836
GO:2000641TAS-regulation of early endosome to late endosome transport19565474
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAP2K2ARAF11159111909642 Reconstituted Complex; Two-hybrid
MAP2K2ARAF10686411909642 Reconstituted Complex; Two-hybrid
MAP2K2MAPK111158011823456 Two-hybrid
MAP2K2MAPK111159111823456 Two-hybrid
MAP2K2MAPK31115818226933 8626767 9006895 Biochemical Activity; Reconstituted Complex; Two-hybrid
MAP2K2MAPK31115918226933 8626767 9006895 Biochemical Activity; Reconstituted Complex; Two-hybrid
MAP2K2MAP2K21115918226933 Biochemical Activity
MEPCEMAP2K212112217643375 Affinity Capture-MS
MEPCEMAP2K211159117643375 Affinity Capture-MS
COPS5MAP2K211618320936779 Two-hybrid
COPS5MAP2K211159120936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346867
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041027-1'