Gene Symbol:	MAP2K5 ( HsT17454,MAPKK5,MEK5,PRKMK5 )
Gene Full Name:	mitogen-activated protein kinase kinase 5
Band:	15q23
Quick Links	Entrez ID:5607; OMIM: 602520; Uniprot ID:MP2K5_HUMAN; ENSEMBL ID: ENSG00000137764; HGNC ID: 6845
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	IEA	-	nucleus	-
GO:0005737	IBA	-	cytoplasm	-
GO:0005819	IEA	-	spindle	-
GO:0005829	IEA	-	cytosol	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0004672	TAS	-	protein kinase activity	7759517
GO:0004702	IBA	-	signal transducer, downstream of receptor, with serine/threonine kinase activity	-
GO:0004708	IEA	-	MAP kinase kinase activity	-
GO:0004713	IEA	-	protein tyrosine kinase activity	-
GO:0005515	IPI	-	protein binding	7759517
GO:0005524	IEA	-	ATP binding	-
GO:0046872	IEA	-	metal ion binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000122	ISS	-	negative regulation of transcription from RNA polymerase II promoter	-
GO:0000187	ISS	-	activation of MAPK activity	20551324
GO:0007165	TAS	-	signal transduction	7759517
GO:0007507	IEA	-	heart development	-
GO:0018108	IEA	-	peptidyl-tyrosine phosphorylation	-
GO:0030307	IEA	-	positive regulation of cell growth	-
GO:0032088	ISS	-	negative regulation of NF-kappaB transcription factor activity	20551324
GO:0034115	ISS	-	negative regulation of heterotypic cell-cell adhesion	20551324
GO:0043154	ISS	-	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	20551324
GO:0045415	ISS	-	negative regulation of interleukin-8 biosynthetic process	20551324
GO:0045944	ISS	-	positive regulation of transcription from RNA polymerase II promoter	-
GO:0050679	IEA	-	positive regulation of epithelial cell proliferation	-
GO:0051247	ISS	-	positive regulation of protein metabolic process	-
GO:0060761	ISS	-	negative regulation of response to cytokine stimulus	20551324
GO:0070375	IEA	-	ERK5 cascade	-
GO:0071363	ISS	-	cellular response to growth factor stimulus	20551324
GO:0071499	TAS	-	cellular response to laminar fluid shear stress	20551324
GO:0090051	ISS	-	negative regulation of cell migration involved in sprouting angiogenesis	20551324
GO:2000342	ISS	-	negative regulation of chemokine (C-X-C motif) ligand 2 production	20551324
GO:2001240	ISS	-	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	20551324

Gene Symbol	Interactant	Interaction ID	References	Description
MAP2K5	ENO1	111593	15805119	Affinity Capture-Western
MAP2K5	ENO1	108338	15805119	Affinity Capture-Western
MAP2K5	MAP3K3	110379	11073940 14743216	Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
MAP2K5	MAP3K3	111593	11073940 14743216	Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
MAP2K5	PRKCZ	111576	11158308	Affinity Capture-Western; Reconstituted Complex
MAP2K5	PRKCZ	111593	11158308	Affinity Capture-Western; Reconstituted Complex
MAP2K5	MAPK7	111584	7759517	Reconstituted Complex; Two-hybrid
MAP2K5	MAPK7	111593	7759517	Reconstituted Complex; Two-hybrid
MAP2K5	MAP2K5	111593	7759517	Biochemical Activity
MAP3K2	MAP2K5	115969	11073940	Affinity Capture-Western; Two-hybrid
MAP3K2	MAP2K5	111593	11073940	Affinity Capture-Western; Two-hybrid
YWHAZ	MAP2K5	113366	20936779	Two-hybrid
YWHAZ	MAP2K5	111593	20936779	Two-hybrid
CDC42BPB	MAP2K5	114947	20936779	Two-hybrid
CDC42BPB	MAP2K5	111593	20936779	Two-hybrid

Gene Symbol	Interactant	Interaction ID	References	Description
SQSTM1	MAP2K5	295421	12813044	MEK5 interacts with p62. This interaction was modelled on a demonstrated interaction between mouse MEK5 and human p62.
MAP3K2	MAP2K5	215376	12659851	MEKK2 phosphorylates an unspecified isoform of MEK5. This interaction was modeled on a demonstrated interaction between MEKK2 from an unspecified species and MEK5 from an unspecified species.

AutismKB 2.0

Annotation Details for MAP2K5