AutismKB 2.0

Annotation Details for MAP2K6


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Basic Information Top
Gene Symbol:MAP2K6 ( MAPKK6,MEK6,MKK6,PRKMK6,SAPKK3 )
Gene Full Name: mitogen-activated protein kinase kinase 6
Band: 17q24.3
Quick LinksEntrez ID:5608; OMIM: 601254; Uniprot ID:MP2K6_HUMAN; ENSEMBL ID: ENSG00000108984; HGNC ID: 6846
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0005737IBA-cytoplasm-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005856IEA-cytoskeleton-
GO ID Evidence Qualifier GO_term References
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004702IBA-signal transducer, downstream of receptor, with serine/threonine kinase activity-
GO:0004708IBA-MAP kinase kinase activity-
GO:0004708TAS-MAP kinase kinase activity-
GO:0004713IEA-protein tyrosine kinase activity-
GO:0005515IPI-protein binding11035004
GO:0005524IEA-ATP binding-
GO:0019901IPI-protein kinase binding11279118
GO ID Evidence Qualifier GO_term References
GO:0000165IEA-MAPK cascade-
GO:0000187TAS-activation of MAPK activity-
GO:0002931IEA-response to ischemia-
GO:0006351IEA-transcription, DNA-templated-
GO:0006355IEA-regulation of transcription, DNA-templated-
GO:0006915IEA-apoptotic process-
GO:0006975TAS-DNA damage induced protein phosphorylation10848581
GO:0007050TAS-cell cycle arrest10848581
GO:0007165TAS-signal transduction8621675
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0022602IEA-ovulation cycle process-
GO:0032308IEA-positive regulation of prostaglandin secretion-
GO:0035897TAS-proteolysis in other organism-
GO:0042493IEA-response to drug-
GO:0043065IEA-positive regulation of apoptotic process-
GO:0051770IEA-positive regulation of nitric-oxide synthase biosynthetic process-
GO:0060048IEA-cardiac muscle contraction-
GO:0070423TAS-nucleotide-binding oligomerization domain containing signaling pathway-
GO:0072709IEA-cellular response to sorbitol-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAP2K6MAPK141115948622669 8626699 11279118 12697810 Biochemical Activity
MAP2K6MAPK141078198622669 8626699 11279118 12697810 Biochemical Activity
MAP2K6SMAD711026712589052 Affinity Capture-Western
MAP2K6SMAD711159412589052 Affinity Capture-Western
MAP2K6MAP3K41103809841871 Biochemical Activity
MAP2K6MAP3K41115949841871 Biochemical Activity
MAP2K6MAP3K511159411689443 12820963 Biochemical Activity; Reconstituted Complex
MAP2K6MAP3K511038111689443 12820963 Biochemical Activity; Reconstituted Complex
MAP2K6NPHS111092811562357 Phenotypic Suppression
MAP2K6NPHS111159411562357 Phenotypic Suppression
MAP2K6PLCB211134612054652 Affinity Capture-Western
MAP2K6PLCB211159412054652 Affinity Capture-Western
MAP2K6MAP2K311159411562357 Phenotypic Enhancement
MAP2K6MAP2K311159211562357 Phenotypic Enhancement
MAP3K7MAP2K611274810094049 10838074 11460167 14633987 Biochemical Activity
MAP3K7MAP2K611159410094049 10838074 11460167 14633987 Biochemical Activity
TAOK2MAP2K611475011279118 Affinity Capture-Western; Biochemical Activity
TAOK2MAP2K611159411279118 Affinity Capture-Western; Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346870
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010202-3'