AutismKB 2.0

Annotation Details for EIF2AK2


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Basic Information Top
Gene Symbol:EIF2AK2 ( EIF2AK1,MGC126524,PKR,PRKR )
Gene Full Name: eukaryotic translation initiation factor 2-alpha kinase 2
Band: 2p22.2
Quick LinksEntrez ID:5610; OMIM: 176871; Uniprot ID:E2AK2_HUMAN; ENSEMBL ID: ENSG00000055332; HGNC ID: 9437
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005737IDA-cytoplasm15121867
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005840TAS-ribosome10390359
GO:0016020IDA-membrane19946888
GO:0048471IDA-perinuclear region of cytoplasm15121867
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22681889
GO:0003725IDA-double-stranded RNA binding21266579
GO:0004672IDA-protein kinase activity12882984
GO:0004672IMP-protein kinase activity21123651
GO:0004674TAS-protein serine/threonine kinase activity1695551
GO:0004694IMP-eukaryotic translation initiation factor 2alpha kinase activity25329545
GO:0004715IEA-non-membrane spanning protein tyrosine kinase activity-
GO:0005515IPI-protein binding8576172
GO:0005524IEA-ATP binding-
GO:0019888TAS-protein phosphatase regulator activity10866685
GO ID Evidence Qualifier GO_term References
GO:0000186IMP-activation of MAPKK activity15229216
GO:0001819ISS-positive regulation of cytokine production-
GO:0006351IEA-transcription, DNA-templated-
GO:0006412IEA-translation-
GO:0006468IDA-protein phosphorylation19189853
GO:0008285TAS-negative regulation of cell proliferation1351683
GO:0009615IMP-response to virus19189853
GO:0009636IEA-response to toxic substance-
GO:0010998IEA-regulation of translational initiation by eIF2 alpha phosphorylation-
GO:0017148IDA-negative regulation of translation12882984
GO:0017148IMP-negative regulation of translation12610133
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0030683TAS-evasion or tolerance by virus of host immune response-
GO:0030968IEA-endoplasmic reticulum unfolded protein response-
GO:0032722ISS-positive regulation of chemokine production-
GO:0032874ISS-positive regulation of stress-activated MAPK cascade-
GO:0033689IMP-negative regulation of osteoblast proliferation16216244
GO:0034198IMP-cellular response to amino acid starvation25329545
GO:0035455IDA-response to interferon-alpha19840259
GO:0043066IEA-negative regulation of apoptotic process-
GO:0045071IMP-negative regulation of viral genome replication19189853
GO:0045087IEA-innate immune response-
GO:0046777IDA-protein autophosphorylation22801494
GO:0046777IMP-protein autophosphorylation16216244
GO:0051092IDA-positive regulation of NF-kappaB transcription factor activity15121867
GO:0051607IEA-defense response to virus-
GO:1900225ISS-regulation of NLRP3 inflammasome complex assembly-
GO:1901224ISS-positive regulation of NIK/NF-kappaB signaling-
GO:1901532ISS-regulation of hematopoietic progenitor cell differentiation-
GO:1902033ISS-regulation of hematopoietic stem cell proliferation-
GO:1902036ISS-regulation of hematopoietic stem cell differentiation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EIF2AK2CHUK11159610848580 Affinity Capture-Western
EIF2AK2CHUK10756910848580 Affinity Capture-Western
EIF2AK2EIF2S111159619364808 Reconstituted Complex; Two-hybrid
EIF2AK2EIF2S110828519364808 Reconstituted Complex; Two-hybrid
EIF2AK2FANCC11159612397061 Affinity Capture-Western
EIF2AK2FANCC10847312397061 Affinity Capture-Western
EIF2AK2HSP90AA111159611447118 Affinity Capture-Western
EIF2AK2HSP90AA110955211447118 Affinity Capture-Western
EIF2AK2IKBKB10976710848580 Affinity Capture-Western
EIF2AK2IKBKB11159610848580 Affinity Capture-Western
EIF2AK2ILF210982111438540 Biochemical Activity
EIF2AK2ILF211159611438540 Biochemical Activity
EIF2AK2ILF310982210320367 10400669 11438536 11438540 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
EIF2AK2ILF311159610320367 10400669 11438536 11438540 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
EIF2AK2MAP3K511159612473108 Affinity Capture-Western
EIF2AK2MAP3K511038112473108 Affinity Capture-Western
EIF2AK2PDGFRB11118511350938 Affinity Capture-Western
EIF2AK2PDGFRB11159611350938 Affinity Capture-Western
EIF2AK2PPP1CA11159612138106 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
EIF2AK2PPP1CA11149312138106 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
EIF2AK2PPP2R5A11151710866685 Affinity Capture-Western
EIF2AK2PPP2R5A11159610866685 Affinity Capture-Western
EIF2AK2EIF2AK21115967568151 10848580 Affinity Capture-Western; Far Western; Two-hybrid
TARBP2EIF2AK21127587568151 11438532 Far Western; Two-hybrid
TARBP2EIF2AK21115967568151 11438532 Far Western; Two-hybrid
DNAJC3EIF2AK21115968576172 9447982 Reconstituted Complex; Two-hybrid
DNAJC3EIF2AK21115978576172 9447982 Reconstituted Complex; Two-hybrid
STAT1EIF2AK21126499135145 11278865 Affinity Capture-Western; Reconstituted Complex
STAT1EIF2AK21115969135145 11278865 Affinity Capture-Western; Reconstituted Complex
HIST2H2ACEIF2AK21139349447982 Biochemical Activity
HIST2H2ACEIF2AK21115969447982 Biochemical Activity
PRKRAEIF2AK21141439687506 11985496 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
PRKRAEIF2AK21115969687506 11985496 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
TP53EIF2AK211159610348343 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TP53EIF2AK211301010348343 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
METAP2EIF2AK211618411123929 Affinity Capture-Western; Reconstituted Complex
METAP2EIF2AK211159611123929 Affinity Capture-Western; Reconstituted Complex
STAT3EIF2AK211265111350938 Affinity Capture-Western
STAT3EIF2AK211159611350938 Affinity Capture-Western
PTGES3EIF2AK211595211447118 Affinity Capture-Western
PTGES3EIF2AK211159611447118 Affinity Capture-Western
PRKRIP1EIF2AK212282412679338 Affinity Capture-Western
PRKRIP1EIF2AK211159612679338 Affinity Capture-Western
DBNLEIF2AK211880917353931 Affinity Capture-MS
DBNLEIF2AK211159617353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
EIF2AK2rs2254958 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1353449
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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