AutismKB 2.0

Annotation Details for PRNP


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Basic Information Top
Gene Symbol:PRNP ( ASCR,CD230,CJD,GSS,MGC26679,PRIP,PrP,PrP27-30,PrP33-35C,PrPc,prion )
Gene Full Name: prion protein
Band: 20p13
Quick LinksEntrez ID:5621; OMIM: 176640; Uniprot ID:PRIO_HUMAN; ENSEMBL ID: ENSG00000171867; HGNC ID: 9449
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737TAS-cytoplasm16004966
GO:0005783ISS-endoplasmic reticulum-
GO:0005794ISS-Golgi apparatus-
GO:0005829IDA-cytosol-
GO:0005886IDA-plasma membrane16254249
GO:0005886ISS-plasma membrane-
GO:0009986IDA-cell surface18419754
GO:0014069TAS-postsynaptic density22820466
GO:0016234IMP-inclusion body20564047
GO:0019898TAS-extrinsic component of membrane16004966
GO:0030425IEA-dendrite-
GO:0031362NAS-anchored component of external side of plasma membrane22293988
GO:0031965IDA-nuclear membrane-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0045121IDA-membrane raft16254249
GO:0045121IMP-membrane raft23386614
GO:0045121ISS-membrane raft-
GO:0070062IDA-extracellular exosome19056867
GO:0098794TAS-postsynapse26224839
GO ID Evidence Qualifier GO_term References
GO:0001540IPI-amyloid-beta binding22820466
GO:0001540TAS-amyloid-beta binding21593310
GO:0004871IEA-signal transducer activity-
GO:0004872IEA-receptor activity-
GO:0005507IDA-copper ion binding11900542
GO:0005507TAS-copper ion binding16294306
GO:0005515IPI-protein binding16286452
GO:0005521IEA-lamin binding-
GO:0008017IDA-microtubule binding16004966
GO:0015631IDA-tubulin binding16004966
GO:0042802IMP-identical protein binding20564047
GO:0042802IPI-identical protein binding16286452
GO:0043008IEA-ATP-dependent protein binding-
GO:0044325IEA-ion channel binding-
GO:0051087IEA-chaperone binding-
GO:1903135IEA-cupric ion binding-
GO:1903136IMP-cuprous ion binding20564047
GO ID Evidence Qualifier GO_term References
GO:0001933ISS-negative regulation of protein phosphorylation-
GO:0006878NAS-cellular copper ion homeostasis16004966
GO:0006979ISS-response to oxidative stress-
GO:0007050IEA-cell cycle arrest-
GO:0007165IEA-signal transduction-
GO:0007616TAS-long-term memory19242475
GO:0008152TAS-metabolic process3755672
GO:0010955TAS-negative regulation of protein processing23386614
GO:0031648IMP-protein destabilization20564047
GO:0032689ISS-negative regulation of interferon-gamma production-
GO:0032700ISS-negative regulation of interleukin-17 production-
GO:0032703ISS-negative regulation of interleukin-2 production-
GO:0035690IEA-cellular response to drug-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043086IDA-negative regulation of catalytic activity23386614
GO:0043433ISS-negative regulation of sequence-specific DNA binding transcription factor activity-
GO:0043525IMP-positive regulation of neuron apoptotic process20564047
GO:0046007ISS-negative regulation of activated T cell proliferation-
GO:0046686IEA-response to cadmium ion-
GO:0050731IDA-positive regulation of peptidyl-tyrosine phosphorylation22820466
GO:0050860ISS-negative regulation of T cell receptor signaling pathway-
GO:0051260IMP-protein homooligomerization20564047
GO:0070885ISS-negative regulation of calcineurin-NFAT signaling cascade-
GO:0071280IDA-cellular response to copper ion16254249
GO:0090314IEA-positive regulation of protein targeting to membrane-
GO:1900272IEA-negative regulation of long-term synaptic potentiation-
GO:1901379IEA-regulation of potassium ion transmembrane transport-
GO:1902951IEA-negative regulation of dendritic spine maintenance-
GO:1904645IEA-response to amyloid-beta-
GO:1905664IEA-regulation of calcium ion import across plasma membrane-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
STIP1PRNP11616212093732 Affinity Capture-Western; Reconstituted Complex
STIP1PRNP11160612093732 Affinity Capture-Western; Reconstituted Complex
SRRM2PRNP11160616159877 Affinity Capture-MS
SRRM2PRNP11707116159877 Affinity Capture-MS
BAT3PRNP11160616169070 Two-hybrid
BAT3PRNP11364716169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
PRNPPRNP-102C/G, PRNP_1368C/T, rs1799990, rs1800014, rs6107516 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
PRNPrs1799990 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
PRNPrs1799990, rs1800014 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97769
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041217-6'