AutismKB 2.0

Annotation Details for PROC


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Basic Information Top
Gene Symbol:PROC ( APC,PC,PROC1 )
Gene Full Name: protein C (inactivator of coagulation factors Va and VIIIa)
Band: 2q14.3
Quick LinksEntrez ID:5624; OMIM: 612283; Uniprot ID:PROC_HUMAN; ENSEMBL ID: ENSG00000115718; HGNC ID: 9451
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576NAS-extracellular region14718574
GO:0005576TAS-extracellular region-
GO:0005615IBA-extracellular space-
GO:0005783IDA-endoplasmic reticulum25748729
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005794IDA-Golgi apparatus25748729
GO:0005796TAS-Golgi lumen-
GO ID Evidence Qualifier GO_term References
GO:0004252IMP-serine-type endopeptidase activity25748729
GO:0004252TAS-serine-type endopeptidase activity15005336
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding15248212
GO ID Evidence Qualifier GO_term References
GO:0001889IEA-liver development-
GO:0006465TAS-signal peptide processing-
GO:0006508NAS-proteolysis12052963
GO:0006888TAS-ER to Golgi vesicle-mediated transport-
GO:0007596TAS-blood coagulation-
GO:0017187TAS-peptidyl-glutamic acid carboxylation-
GO:0030195TAS-negative regulation of blood coagulation15005336
GO:0043066IMP-negative regulation of apoptotic process12563316
GO:0043687TAS-post-translational protein modification-
GO:0044267TAS-cellular protein metabolic process-
GO:0044537IEA-regulation of circulating fibrinogen levels-
GO:0050728IMP-negative regulation of inflammatory response25651845
GO:0050819IMP-negative regulation of coagulation25651845
GO:0050900TAS-leukocyte migration-
GO:1903142IMP-positive regulation of establishment of endothelial barrier25651845
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PROCSERPINA51116082551064 11123896 Co-purification; Reconstituted Complex
PROCSERPINA51111352551064 11123896 Co-purification; Reconstituted Complex
PROCPF41116089395524 Reconstituted Complex
PROCPF41112199395524 Reconstituted Complex
PROCRPROC11160810681521 Reconstituted Complex
PROCRPROC11579710681521 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97771
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060824-5'