AutismKB 2.0

Annotation Details for PROS1


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Basic Information Top
Gene Symbol:PROS1 ( PROS,PS21,PS22,PS23,PS24,PS25,PSA )
Gene Full Name: protein S (alpha)
Band: 3q11.1
Quick LinksEntrez ID:5627; OMIM: 176880; Uniprot ID:PROS_HUMAN; ENSEMBL ID: ENSG00000184500; HGNC ID: 9456
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139TAS-Golgi membrane-
GO:0005576NAS-extracellular region14718574
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space14607961
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005796TAS-Golgi lumen-
GO:0005886TAS-plasma membrane-
GO:0031093TAS-platelet alpha granule lumen-
GO:0070062IDA-extracellular exosome23533145
GO:0072562IDA-blood microparticle22516433
GO ID Evidence Qualifier GO_term References
GO:0004866TAS-endopeptidase inhibitor activity8146182
GO:0005509IEA-calcium ion binding-
GO ID Evidence Qualifier GO_term References
GO:0002576TAS-platelet degranulation-
GO:0006465TAS-signal peptide processing-
GO:0006888TAS-ER to Golgi vesicle-mediated transport-
GO:0007596TAS-blood coagulation-
GO:0010951IEA-negative regulation of endopeptidase activity-
GO:0017187TAS-peptidyl-glutamic acid carboxylation-
GO:0030449TAS-regulation of complement activation-
GO:0042730IEA-fibrinolysis-
GO:0050900TAS-leukocyte migration-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PROS1F51116118428962 10593904 Reconstituted Complex
PROS1F51084528428962 10593904 Reconstituted Complex
PROS1F81116117620160 Reconstituted Complex
PROS1F81084557620160 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1095733
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018