AutismKB 2.0

Annotation Details for PRSS2


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Basic Information Top
Gene Symbol:PRSS2 ( MGC111183,MGC120174,MGC120175,TRY2,TRY8,TRYP2 )
Gene Full Name: protease, serine, 2 (trypsin 2)
Band: 7q34
Quick LinksEntrez ID:5645; OMIM: 601564; Uniprot ID:TRY2_HUMAN; ENSEMBL ID: ENSG00000204983; HGNC ID: 9483
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IDA-extracellular region12731883
GO:0005576TAS-extracellular region-
GO:0005615IMP-extracellular space16192646
GO:0031012TAS-extracellular matrix12731883
GO:0035578TAS-azurophil granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0004222TAS-metalloendopeptidase activity-
GO:0004252IDA-serine-type endopeptidase activity12709065
GO:0004252TAS-serine-type endopeptidase activity-
GO:0005509IDA-calcium ion binding12709065
GO:0005515IPI-protein binding16192646
GO:0008236TAS-serine-type peptidase activity-
GO ID Evidence Qualifier GO_term References
GO:0006508IDA-proteolysis12731883
GO:0007586IBA-digestion-
GO:0019730TAS-antimicrobial humoral response-
GO:0022617TAS-extracellular matrix disassembly-
GO:0030307TAS-positive regulation of cell growth12731883
GO:0030574IDA-collagen catabolic process12731883
GO:0030574IMP-collagen catabolic process16192646
GO:0030574TAS-collagen catabolic process-
GO:0043312TAS-neutrophil degranulation-
GO:0045785TAS-positive regulation of cell adhesion12731883
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018