AutismKB 2.0

Annotation Details for SPIRE1


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Basic Information Top
Gene Symbol:SPIRE1 ( MGC150621,MGC150622,Spir-1 )
Gene Full Name: spire homolog 1 (Drosophila)
Band: 18p11.21
Quick LinksEntrez ID:56907; OMIM: 609216; Uniprot ID:SPIR1_HUMAN; ENSEMBL ID: ENSG00000134278; HGNC ID: 30622
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0005856IEA-cytoskeleton-
GO:0005886IEA-plasma membrane-
GO:0005938ISS-cell cortex-
GO:0030659ISS-cytoplasmic vesicle membrane-
GO:0032154ISScolocalizes_withcleavage furrow-
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0003779IEA-actin binding-
GO ID Evidence Qualifier GO_term References
GO:0015031IEA-protein transport-
GO:0016192ISS-vesicle-mediated transport-
GO:0030036IMP-actin cytoskeleton organization21620703
GO:0036089ISS-cleavage furrow formation-
GO:0040038ISS-polar body extrusion after meiotic divisions-
GO:0045010IEA-actin nucleation-
GO:0046907ISS-intracellular transport-
GO:0051295IMP-establishment of meiotic spindle localization21620703
GO:0070649ISS-formin-nucleated actin cable assembly-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SPIRE1SFN10907215778465 Affinity Capture-MS
SPIRE1SFN12123715778465 Affinity Capture-MS
SPIRE1YWHAQ12123717353931 Affinity Capture-MS
SPIRE1YWHAQ11616817353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1915416
  • Data Attributes: HomoloGene calculated
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018