AutismKB 2.0

Annotation Details for PSMB4


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Basic Information Top
Gene Symbol:PSMB4 ( HN3,HsN3,PROS-26,PROS26 )
Gene Full Name: proteasome (prosome, macropain) subunit, beta type, 4
Band: 1q21.3
Quick LinksEntrez ID:5692; OMIM: 602177; Uniprot ID:PSB4_HUMAN; ENSEMBL ID: ENSG00000159377; HGNC ID: 9541
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000502IDA-proteasome complex17323924
GO:0005634IDA-nucleus21630459
GO:0005634TAS-nucleus16130169
GO:0005654TAS-nucleoplasm-
GO:0005829TAS-cytosol-
GO:0005839ISS-proteasome core complex-
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0001530IEA-lipopolysaccharide binding-
GO:0004298IEA-threonine-type endopeptidase activity-
GO:0005515IPI-protein binding25416956
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000209TAS-protein polyubiquitination-
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0002479TAS-antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-
GO:0002862IEA-negative regulation of inflammatory response to antigenic stimulus-
GO:0006521TAS-regulation of cellular amino acid metabolic process-
GO:0010972TAS-negative regulation of G2/M transition of mitotic cell cycle-
GO:0016032IEA-viral process-
GO:0016579TAS-protein deubiquitination-
GO:0031145TAS-anaphase-promoting complex-dependent catabolic process-
GO:0031146TAS-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0038061TAS-NIK/NF-kappaB signaling-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0043161TAS-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0043488TAS-regulation of mRNA stability-
GO:0043687TAS-post-translational protein modification-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051436TAS-negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle-
GO:0051437TAS-positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition-
GO:0055085TAS-transmembrane transport-
GO:0060071TAS-Wnt signaling pathway, planar cell polarity pathway-
GO:0061418TAS-regulation of transcription from RNA polymerase II promoter in response to hypoxia-
GO:0090090TAS-negative regulation of canonical Wnt signaling pathway-
GO:0090263TAS-positive regulation of canonical Wnt signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PSMB4SMAD111026111438941 11571290 12097147 Affinity Capture-Western; Two-hybrid
PSMB4SMAD111166511438941 11571290 12097147 Affinity Capture-Western; Two-hybrid
PSMB4OAZ111100011571290 Two-hybrid
PSMB4OAZ111166511571290 Two-hybrid
SLX4PSMB412409719596235 Affinity Capture-MS
SLX4PSMB411166519596235 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1098257
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050417-333'