AutismKB 2.0

Annotation Details for PAK6


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Basic Information Top
Gene Symbol:PAK6 ( PAK5 )
Gene Full Name: p21 protein (Cdc42/Rac)-activated kinase 6
Band: 15q15.1
Quick LinksEntrez ID:56924; OMIM: 608110; Uniprot ID:PAK6_HUMAN; ENSEMBL ID: ENSG00000137843; HGNC ID: 16061
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001650IDA-fibrillar center-
GO:0005634IDA-nucleus-
GO:0005737IBA-cytoplasm-
GO:0030054IDA-cell junction-
GO ID Evidence Qualifier GO_term References
GO:0004702IBA-signal transducer, downstream of receptor, with serine/threonine kinase activity-
GO:0005515IPI-protein binding24510904
GO:0005524IEA-ATP binding-
GO:0045296IDA-cadherin binding25468996
GO ID Evidence Qualifier GO_term References
GO:0000278IBANOTmitotic cell cycle-
GO:0006355TAS-regulation of transcription, DNA-templated20070256
GO:0006915TAS-apoptotic process20070256
GO:0007010TAS-cytoskeleton organization20070256
GO:0023014IEA-signal transduction by protein phosphorylation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PAK6AKT112125111773441 Reconstituted Complex
PAK6AKT110671011773441 Reconstituted Complex
PAK6AR12125111278661 11773441 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PAK6AR10686211278661 11773441 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PAK6CDC4212125111773441 20936779 Reconstituted Complex; Two-hybrid
PAK6CDC4210743311773441 20936779 Reconstituted Complex; Two-hybrid
PAK6ESR112125111773441 Reconstituted Complex
PAK6ESR110840311773441 Reconstituted Complex
PAK6YWHAQ12125117353931 Affinity Capture-MS
PAK6YWHAQ11616817353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2679420
  • Data Attributes: HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018